Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin

Marja K Pasanen, Hanna Fredrikson, Pertti J Neuvonen, Mikko Niemi

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    "Thirty-two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of atorvastatin and 10 mg dose of rosuvastatin with a washout period of 1 week. Subjects with the SLCO1B1 c.521CC genotype (n=4) had a 144% ( P<0.001) or 61% (P=0.049) greater mean area under the plasma atorvastatin concentration-time curve from 0 to 48 h (AUC(0-48 h)) than those with the c.521TT (n=16) or c.521TC (n=12) genotype, respectively. The AUC(0-48 h) of 2-hydroxyatorvastatin was 100% greater in subjects with the c.521CC genotype than in those with the c.521TT genotype (P=0.018). Rosuvastatin AUC(0-48 h) and peak plasma concentration (C-max) were 65% (P=0.002) and 79% (P=0.003) higher in subjects with the c.521CC genotype than in those with the c.521TT genotype. These results indicate that, unexpectedly, SLCO1B1 polymorphism has a larger effect on the AUC of atorvastatin than on the more hydrophilic rosuvastatin."
    Original languageEnglish
    JournalClinical Pharmacology and Therapeutics
    Volume82
    Issue number6
    Pages (from-to)726-733
    Number of pages8
    ISSN0009-9236
    DOIs
    Publication statusPublished - 2007
    MoE publication typeA1 Journal article-refereed

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