Direct compression properties of chitin and chitosan

Viviana Mir; Jyrki Heinämäki; Osmo Antikainen; Ofelia Revoredo; Antonio Colarte; Olga Nieto; Jouko Yliruusi

doi:10.1016/j.ejpb.2008.01.029

Direct compression properties of chitin and chitosan

Viviana Mir, Jyrki Heinämäki, Osmo Antikainen, Ofelia Revoredo, Antonio Colarte, Olga Nieto, Jouko Yliruusi

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan was found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications. (C) 2008 Elsevier B.V. All rights reserved.

Original language	English
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	69
Issue number	3
Pages (from-to)	964-968
Number of pages	5
ISSN	0939-6411
DOIs	https://doi.org/10.1016/j.ejpb.2008.01.029
Publication status	Published - 2008
MoE publication type	A1 Journal article-refereed

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10.1016/j.ejpb.2008.01.029

Cite this

@article{73c712e4e1da470e812860129eb46454,

title = "Direct compression properties of chitin and chitosan",

abstract = "Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan was found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications. (C) 2008 Elsevier B.V. All rights reserved.",

author = "Viviana Mir and Jyrki Hein{\"a}m{\"a}ki and Osmo Antikainen and Ofelia Revoredo and Antonio Colarte and Olga Nieto and Jouko Yliruusi",

year = "2008",

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volume = "69",

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journal = "European Journal of Pharmaceutics and Biopharmaceutics",

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TY - JOUR

T1 - Direct compression properties of chitin and chitosan

AU - Mir, Viviana

AU - Heinämäki, Jyrki

AU - Antikainen, Osmo

AU - Revoredo, Ofelia

AU - Colarte, Antonio

AU - Nieto, Olga

AU - Yliruusi, Jouko

PY - 2008

Y1 - 2008

N2 - Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan was found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications. (C) 2008 Elsevier B.V. All rights reserved.

AB - Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan was found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications. (C) 2008 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.ejpb.2008.01.029

DO - 10.1016/j.ejpb.2008.01.029

M3 - Article

VL - 69

SP - 964

EP - 968

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 3

ER -