Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan was found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications. (C) 2008 Elsevier B.V. All rights reserved.
|Journal||European Journal of Pharmaceutics and Biopharmaceutics|
|Number of pages||5|
|Publication status||Published - 2008|
|MoE publication type||A1 Journal article-refereed|