Direct compression properties of chitin and chitosan

Viviana Mir, Jyrki Heinämäki, Osmo Antikainen, Ofelia Revoredo, Antonio Colarte, Olga Nieto, Jouko Yliruusi

    Research output: Contribution to journalArticleScientificpeer-review


    Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan was found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications. (C) 2008 Elsevier B.V. All rights reserved.
    Original languageEnglish
    JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
    Issue number3
    Pages (from-to)964-968
    Number of pages5
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed

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