Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

Momoko Horikoshi, Reedik Maegi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, Anubha Mahajan, Letizia Marullo, Gudmar Thorleifsson, Sara Haegg, Jouke-Jan Hottenga, Claes Ladenvall, Janina S. Ried, Thomas W. Winkler, Sara M. Willems, Natalia Tsernikova, Tonu Esko, Marian Beekman, Christopher P. Nelson, Christina Willenborg, Steven Wiltshire & 31 others Teresa Ferreira, Juan Fernandez, Kyle J. Gaulton, Valgerdur Steinthorsdottir, Anders Hamsten, Patrik K. E. Magnusson, Gonneke Willemsen, Yuri Milaneschi, Neil R. Robertson, Christopher J. Groves, Amanda J. Bennett, Terho Lehtimaeki, Jorma S. Viikari, Johan Rung, Valeriya Lyssenko, Markus Perola, Iris M. Heid, Christian Herder, Harald Grallert, Martina Mueller-Nurasyid, Michael Roden, Elina Hypponen, Aaron Isaacs, Elisabeth M. van Leeuwen, Lennart C. Karssen, Evelin Mihailov, Jaakko Kaprio, Johan G. Eriksson, Leif Groop, Samuli Ripatti, Engage Consortium

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number1005230
JournalPLoS Genetics
Volume11
Issue number7
Number of pages24
ISSN1553-7390
DOIs
Publication statusPublished - Jul 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • BODY-MASS INDEX
  • RARE GENETIC-VARIATION
  • TYPE-2 DIABETES RISK
  • WAIST-HIP RATIO
  • LOW-FREQUENCY
  • INSULIN-RESISTANCE
  • FASTING GLUCOSE
  • GENOTYPE IMPUTATION
  • ASIAN POPULATIONS
  • 3111 Biomedicine

Cite this

Horikoshi, M., Maegi, R., van de Bunt, M., Surakka, I., Sarin, A-P., Mahajan, A., ... Engage Consortium (2015). Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. PLoS Genetics, 11(7), [1005230]. https://doi.org/10.1371/journal.pgen.1005230
Horikoshi, Momoko ; Maegi, Reedik ; van de Bunt, Martijn ; Surakka, Ida ; Sarin, Antti-Pekka ; Mahajan, Anubha ; Marullo, Letizia ; Thorleifsson, Gudmar ; Haegg, Sara ; Hottenga, Jouke-Jan ; Ladenvall, Claes ; Ried, Janina S. ; Winkler, Thomas W. ; Willems, Sara M. ; Tsernikova, Natalia ; Esko, Tonu ; Beekman, Marian ; Nelson, Christopher P. ; Willenborg, Christina ; Wiltshire, Steven ; Ferreira, Teresa ; Fernandez, Juan ; Gaulton, Kyle J. ; Steinthorsdottir, Valgerdur ; Hamsten, Anders ; Magnusson, Patrik K. E. ; Willemsen, Gonneke ; Milaneschi, Yuri ; Robertson, Neil R. ; Groves, Christopher J. ; Bennett, Amanda J. ; Lehtimaeki, Terho ; Viikari, Jorma S. ; Rung, Johan ; Lyssenko, Valeriya ; Perola, Markus ; Heid, Iris M. ; Herder, Christian ; Grallert, Harald ; Mueller-Nurasyid, Martina ; Roden, Michael ; Hypponen, Elina ; Isaacs, Aaron ; van Leeuwen, Elisabeth M. ; Karssen, Lennart C. ; Mihailov, Evelin ; Kaprio, Jaakko ; Eriksson, Johan G. ; Groop, Leif ; Ripatti, Samuli ; Engage Consortium. / Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. In: PLoS Genetics. 2015 ; Vol. 11, No. 7.
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title = "Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation",
keywords = "GENOME-WIDE ASSOCIATION, BODY-MASS INDEX, RARE GENETIC-VARIATION, TYPE-2 DIABETES RISK, WAIST-HIP RATIO, LOW-FREQUENCY, INSULIN-RESISTANCE, FASTING GLUCOSE, GENOTYPE IMPUTATION, ASIAN POPULATIONS, 3111 Biomedicine",
author = "Momoko Horikoshi and Reedik Maegi and {van de Bunt}, Martijn and Ida Surakka and Antti-Pekka Sarin and Anubha Mahajan and Letizia Marullo and Gudmar Thorleifsson and Sara Haegg and Jouke-Jan Hottenga and Claes Ladenvall and Ried, {Janina S.} and Winkler, {Thomas W.} and Willems, {Sara M.} and Natalia Tsernikova and Tonu Esko and Marian Beekman and Nelson, {Christopher P.} and Christina Willenborg and Steven Wiltshire and Teresa Ferreira and Juan Fernandez and Gaulton, {Kyle J.} and Valgerdur Steinthorsdottir and Anders Hamsten and Magnusson, {Patrik K. E.} and Gonneke Willemsen and Yuri Milaneschi and Robertson, {Neil R.} and Groves, {Christopher J.} and Bennett, {Amanda J.} and Terho Lehtimaeki and Viikari, {Jorma S.} and Johan Rung and Valeriya Lyssenko and Markus Perola and Heid, {Iris M.} and Christian Herder and Harald Grallert and Martina Mueller-Nurasyid and Michael Roden and Elina Hypponen and Aaron Isaacs and {van Leeuwen}, {Elisabeth M.} and Karssen, {Lennart C.} and Evelin Mihailov and Jaakko Kaprio and Eriksson, {Johan G.} and Leif Groop and Samuli Ripatti and {Engage Consortium}",
year = "2015",
month = "7",
doi = "10.1371/journal.pgen.1005230",
language = "English",
volume = "11",
journal = "PLoS Genetics",
issn = "1553-7390",
publisher = "PUBLIC LIBRARY OF SCIENCE",
number = "7",

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Horikoshi, M, Maegi, R, van de Bunt, M, Surakka, I, Sarin, A-P, Mahajan, A, Marullo, L, Thorleifsson, G, Haegg, S, Hottenga, J-J, Ladenvall, C, Ried, JS, Winkler, TW, Willems, SM, Tsernikova, N, Esko, T, Beekman, M, Nelson, CP, Willenborg, C, Wiltshire, S, Ferreira, T, Fernandez, J, Gaulton, KJ, Steinthorsdottir, V, Hamsten, A, Magnusson, PKE, Willemsen, G, Milaneschi, Y, Robertson, NR, Groves, CJ, Bennett, AJ, Lehtimaeki, T, Viikari, JS, Rung, J, Lyssenko, V, Perola, M, Heid, IM, Herder, C, Grallert, H, Mueller-Nurasyid, M, Roden, M, Hypponen, E, Isaacs, A, van Leeuwen, EM, Karssen, LC, Mihailov, E, Kaprio, J, Eriksson, JG, Groop, L, Ripatti, S & Engage Consortium 2015, 'Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation', PLoS Genetics, vol. 11, no. 7, 1005230. https://doi.org/10.1371/journal.pgen.1005230

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. / Horikoshi, Momoko; Maegi, Reedik; van de Bunt, Martijn; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Thorleifsson, Gudmar; Haegg, Sara; Hottenga, Jouke-Jan; Ladenvall, Claes; Ried, Janina S.; Winkler, Thomas W.; Willems, Sara M.; Tsernikova, Natalia; Esko, Tonu; Beekman, Marian; Nelson, Christopher P.; Willenborg, Christina; Wiltshire, Steven; Ferreira, Teresa; Fernandez, Juan; Gaulton, Kyle J.; Steinthorsdottir, Valgerdur; Hamsten, Anders; Magnusson, Patrik K. E.; Willemsen, Gonneke; Milaneschi, Yuri; Robertson, Neil R.; Groves, Christopher J.; Bennett, Amanda J.; Lehtimaeki, Terho; Viikari, Jorma S.; Rung, Johan; Lyssenko, Valeriya; Perola, Markus; Heid, Iris M.; Herder, Christian; Grallert, Harald; Mueller-Nurasyid, Martina; Roden, Michael; Hypponen, Elina; Isaacs, Aaron; van Leeuwen, Elisabeth M.; Karssen, Lennart C.; Mihailov, Evelin; Kaprio, Jaakko; Eriksson, Johan G.; Groop, Leif; Ripatti, Samuli; Engage Consortium.

In: PLoS Genetics, Vol. 11, No. 7, 1005230, 07.2015.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

AU - Horikoshi, Momoko

AU - Maegi, Reedik

AU - van de Bunt, Martijn

AU - Surakka, Ida

AU - Sarin, Antti-Pekka

AU - Mahajan, Anubha

AU - Marullo, Letizia

AU - Thorleifsson, Gudmar

AU - Haegg, Sara

AU - Hottenga, Jouke-Jan

AU - Ladenvall, Claes

AU - Ried, Janina S.

AU - Winkler, Thomas W.

AU - Willems, Sara M.

AU - Tsernikova, Natalia

AU - Esko, Tonu

AU - Beekman, Marian

AU - Nelson, Christopher P.

AU - Willenborg, Christina

AU - Wiltshire, Steven

AU - Ferreira, Teresa

AU - Fernandez, Juan

AU - Gaulton, Kyle J.

AU - Steinthorsdottir, Valgerdur

AU - Hamsten, Anders

AU - Magnusson, Patrik K. E.

AU - Willemsen, Gonneke

AU - Milaneschi, Yuri

AU - Robertson, Neil R.

AU - Groves, Christopher J.

AU - Bennett, Amanda J.

AU - Lehtimaeki, Terho

AU - Viikari, Jorma S.

AU - Rung, Johan

AU - Lyssenko, Valeriya

AU - Perola, Markus

AU - Heid, Iris M.

AU - Herder, Christian

AU - Grallert, Harald

AU - Mueller-Nurasyid, Martina

AU - Roden, Michael

AU - Hypponen, Elina

AU - Isaacs, Aaron

AU - van Leeuwen, Elisabeth M.

AU - Karssen, Lennart C.

AU - Mihailov, Evelin

AU - Kaprio, Jaakko

AU - Eriksson, Johan G.

AU - Groop, Leif

AU - Ripatti, Samuli

AU - Engage Consortium

PY - 2015/7

Y1 - 2015/7

KW - GENOME-WIDE ASSOCIATION

KW - BODY-MASS INDEX

KW - RARE GENETIC-VARIATION

KW - TYPE-2 DIABETES RISK

KW - WAIST-HIP RATIO

KW - LOW-FREQUENCY

KW - INSULIN-RESISTANCE

KW - FASTING GLUCOSE

KW - GENOTYPE IMPUTATION

KW - ASIAN POPULATIONS

KW - 3111 Biomedicine

U2 - 10.1371/journal.pgen.1005230

DO - 10.1371/journal.pgen.1005230

M3 - Article

VL - 11

JO - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7390

IS - 7

M1 - 1005230

ER -

Horikoshi M, Maegi R, van de Bunt M, Surakka I, Sarin A-P, Mahajan A et al. Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. PLoS Genetics. 2015 Jul;11(7). 1005230. https://doi.org/10.1371/journal.pgen.1005230