Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky, Krister Wennerberg

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalCombinatorial Chemistry & High Throughput Screening
Volume18
Issue number1
Pages (from-to)3-17
Number of pages15
ISSN1386-2073
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Biochemical assays
  • cytokinesis
  • HTS
  • MgcRacGAP
  • Rac1
  • small molecule inhibitor
  • POLO-LIKE KINASE-1
  • RHO-FAMILY GTPASES
  • CENTRAL SPINDLE
  • MITOTIC SPINDLE
  • CELL-DIVISION
  • GAP ACTIVITY
  • IN-VITRO
  • CYTOKINESIS
  • RAC
  • CDC42
  • 1182 Biochemistry, cell and molecular biology
  • 3111 Biomedicine

Cite this

@article{0f480ba926fa4b5d85d885a7c6f15982,
title = "Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP",
keywords = "Biochemical assays, cytokinesis, HTS, MgcRacGAP, Rac1, small molecule inhibitor, POLO-LIKE KINASE-1, RHO-FAMILY GTPASES, CENTRAL SPINDLE, MITOTIC SPINDLE, CELL-DIVISION, GAP ACTIVITY, IN-VITRO, CYTOKINESIS, RAC, CDC42, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine",
author = "{van Adrichem}, {Arjan J.} and Annika Fagerholm and Laura Turunen and Anna Lehto and Jani Saarela and Ari Koskinen and Repasky, {Gretchen A.} and Krister Wennerberg",
year = "2015",
language = "English",
volume = "18",
pages = "3--17",
journal = "Combinatorial Chemistry & High Throughput Screening",
issn = "1386-2073",
publisher = "Bentham Science Publishers, Ltd.",
number = "1",

}

Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP. / van Adrichem, Arjan J.; Fagerholm, Annika; Turunen, Laura; Lehto, Anna; Saarela, Jani; Koskinen, Ari; Repasky, Gretchen A.; Wennerberg, Krister.

In: Combinatorial Chemistry & High Throughput Screening, Vol. 18, No. 1, 2015, p. 3-17.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

AU - van Adrichem, Arjan J.

AU - Fagerholm, Annika

AU - Turunen, Laura

AU - Lehto, Anna

AU - Saarela, Jani

AU - Koskinen, Ari

AU - Repasky, Gretchen A.

AU - Wennerberg, Krister

PY - 2015

Y1 - 2015

KW - Biochemical assays

KW - cytokinesis

KW - HTS

KW - MgcRacGAP

KW - Rac1

KW - small molecule inhibitor

KW - POLO-LIKE KINASE-1

KW - RHO-FAMILY GTPASES

KW - CENTRAL SPINDLE

KW - MITOTIC SPINDLE

KW - CELL-DIVISION

KW - GAP ACTIVITY

KW - IN-VITRO

KW - CYTOKINESIS

KW - RAC

KW - CDC42

KW - 1182 Biochemistry, cell and molecular biology

KW - 3111 Biomedicine

M3 - Article

VL - 18

SP - 3

EP - 17

JO - Combinatorial Chemistry & High Throughput Screening

JF - Combinatorial Chemistry & High Throughput Screening

SN - 1386-2073

IS - 1

ER -