Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

Mika J. Välimäki, Maria A. Tölli, Sini M. Kinnunen, Jani Aro, Raisa Serpi, Lotta Pohjolainen, Virpi Talman, Antti Poso, Heikki J. Ruskoaho

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Medicinal Chemistry
Volume60
Issue number18
Pages (from-to)7781-7798
Number of pages18
ISSN0022-2623
DOIs
Publication statusPublished - 28 Sep 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • BRAIN NATRIURETIC PEPTIDE
  • HEAVY-CHAIN GENE
  • STEM-CELLS
  • HEART REGENERATION
  • ADULT HEART
  • EXPRESSION
  • BINDING
  • DISEASE
  • REPAIR
  • CARDIOGENESIS
  • TRANSCRIPTION FACTOR
  • PROTEIN-PROTEIN INTERACTIONS
  • HYPERTROPHY
  • DRUG DISCOVERY
  • 317 Pharmacy

Cite this

@article{310d6947e9bb4d94bb32a54703d095f1,
title = "Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5",
keywords = "BRAIN NATRIURETIC PEPTIDE, HEAVY-CHAIN GENE, STEM-CELLS, HEART REGENERATION, ADULT HEART, EXPRESSION, BINDING, DISEASE, REPAIR, CARDIOGENESIS, TRANSCRIPTION FACTOR , PROTEIN-PROTEIN INTERACTIONS , HYPERTROPHY , DRUG DISCOVERY, 317 Pharmacy",
author = "V{\"a}lim{\"a}ki, {Mika J.} and T{\"o}lli, {Maria A.} and Kinnunen, {Sini M.} and Jani Aro and Raisa Serpi and Lotta Pohjolainen and Virpi Talman and Antti Poso and Ruskoaho, {Heikki J.}",
year = "2017",
month = "9",
day = "28",
doi = "10.1021/acs.jmedchem.7b00816",
language = "English",
volume = "60",
pages = "7781--7798",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "18",

}

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. / Välimäki, Mika J.; Tölli, Maria A.; Kinnunen, Sini M.; Aro, Jani; Serpi, Raisa; Pohjolainen, Lotta; Talman, Virpi; Poso, Antti; Ruskoaho, Heikki J.

In: Journal of Medicinal Chemistry, Vol. 60, No. 18, 28.09.2017, p. 7781-7798.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

AU - Välimäki, Mika J.

AU - Tölli, Maria A.

AU - Kinnunen, Sini M.

AU - Aro, Jani

AU - Serpi, Raisa

AU - Pohjolainen, Lotta

AU - Talman, Virpi

AU - Poso, Antti

AU - Ruskoaho, Heikki J.

PY - 2017/9/28

Y1 - 2017/9/28

KW - BRAIN NATRIURETIC PEPTIDE

KW - HEAVY-CHAIN GENE

KW - STEM-CELLS

KW - HEART REGENERATION

KW - ADULT HEART

KW - EXPRESSION

KW - BINDING

KW - DISEASE

KW - REPAIR

KW - CARDIOGENESIS

KW - TRANSCRIPTION FACTOR

KW - PROTEIN-PROTEIN INTERACTIONS

KW - HYPERTROPHY

KW - DRUG DISCOVERY

KW - 317 Pharmacy

U2 - 10.1021/acs.jmedchem.7b00816

DO - 10.1021/acs.jmedchem.7b00816

M3 - Article

VL - 60

SP - 7781

EP - 7798

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 18

ER -