Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

Simona Selberg, Daria Blokhina, Maria Aatonen, Pertti Koivisto, Antti Siltanen, Eero Mervaala, Esko Kankuri, Mati Karelson

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalCell Reports
Volume26
Issue number13
Pages (from-to)3762-+
Number of pages15
ISSN2211-1247
DOIs
Publication statusPublished - 26 Mar 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • RNA methylation
  • N6-adenosine-methyltransferases
  • N-6-methyladenosine
  • ligand binding
  • computer-aided design
  • epitranscriptomics
  • 1182 Biochemistry, cell and molecular biology

Cite this

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title = "Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site",
keywords = "RNA methylation, N6-adenosine-methyltransferases, N-6-methyladenosine, ligand binding, computer-aided design, epitranscriptomics, 1182 Biochemistry, cell and molecular biology",
author = "Simona Selberg and Daria Blokhina and Maria Aatonen and Pertti Koivisto and Antti Siltanen and Eero Mervaala and Esko Kankuri and Mati Karelson",
year = "2019",
month = "3",
day = "26",
doi = "10.1016/j.celrep.2019.02.100",
language = "English",
volume = "26",
pages = "3762--+",
journal = "Cell Reports",
issn = "2211-1247",
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number = "13",

}

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site. / Selberg, Simona; Blokhina, Daria; Aatonen, Maria; Koivisto, Pertti; Siltanen, Antti; Mervaala, Eero; Kankuri, Esko; Karelson, Mati.

In: Cell Reports, Vol. 26, No. 13, 26.03.2019, p. 3762-+.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

AU - Selberg, Simona

AU - Blokhina, Daria

AU - Aatonen, Maria

AU - Koivisto, Pertti

AU - Siltanen, Antti

AU - Mervaala, Eero

AU - Kankuri, Esko

AU - Karelson, Mati

PY - 2019/3/26

Y1 - 2019/3/26

KW - RNA methylation

KW - N6-adenosine-methyltransferases

KW - N-6-methyladenosine

KW - ligand binding

KW - computer-aided design

KW - epitranscriptomics

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.celrep.2019.02.100

DO - 10.1016/j.celrep.2019.02.100

M3 - Article

VL - 26

SP - 3762-+

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 13

ER -