Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

Simona Selberg; Daria Blokhina; Maria Aatonen; Pertti Koivisto; Antti Siltanen; Eero Mervaala; Esko Kankuri; Mati Karelson

doi:10.1016/j.celrep.2019.02.100

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

Simona Selberg, Daria Blokhina, Maria Aatonen, Pertti Koivisto, Antti Siltanen, Eero Mervaala, Esko Kankuri, Mati Karelson

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Cell Reports
Volume	26
Issue number	13
Pages (from-to)	3762-+
Number of pages	15
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2019.02.100
Publication status	Published - 26 Mar 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

RNA methylation
N6-adenosine-methyltransferases
N-6-methyladenosine
ligand binding
computer-aided design
epitranscriptomics
1182 Biochemistry, cell and molecular biology

Access to Document

10.1016/j.celrep.2019.02.100

1-s2.0-S2211124719302864-mainFinal published version, 2.85 MBLicence: CC BY-NC-ND

Cite this

@article{390bb22de6994bd0bcd377aec29a3064,

title = "Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site",

keywords = "RNA methylation, N6-adenosine-methyltransferases, N-6-methyladenosine, ligand binding, computer-aided design, epitranscriptomics, 1182 Biochemistry, cell and molecular biology",

author = "Simona Selberg and Daria Blokhina and Maria Aatonen and Pertti Koivisto and Antti Siltanen and Eero Mervaala and Esko Kankuri and Mati Karelson",

year = "2019",

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journal = "Cell Reports",

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T1 - Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

AU - Selberg, Simona

AU - Blokhina, Daria

AU - Aatonen, Maria

AU - Koivisto, Pertti

AU - Siltanen, Antti

AU - Mervaala, Eero

AU - Kankuri, Esko

AU - Karelson, Mati

PY - 2019/3/26

Y1 - 2019/3/26

KW - RNA methylation

KW - N6-adenosine-methyltransferases

KW - N-6-methyladenosine

KW - ligand binding

KW - computer-aided design

KW - epitranscriptomics

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.celrep.2019.02.100

DO - 10.1016/j.celrep.2019.02.100

M3 - Article

SN - 2211-1247

VL - 26

SP - 3762-+

JO - Cell Reports

JF - Cell Reports

IS - 13

ER -