Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Ziga Jakopin, Janez Ilas, Michaela Barancokova, Matjaz Brvar, Paivi Tammela, Marija Sollner Dolenc, Tihomir Tomasic, Danijel Kikelj

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalEuropean Journal of Medicinal Chemistry
Volume130
Pages (from-to)171-184
Number of pages14
ISSN0223-5234
DOIs
Publication statusPublished - 21 Apr 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 1,2,4-Oxadiazoles
  • DNA gyrase inhibition
  • Topoisomerase IV inhibition
  • Antibacterial screening
  • Computer-aided drug design
  • ATP-BINDING SITE
  • TOPOISOMERASE-IV
  • ANTIBACTERIAL ACTIVITY
  • PYRROLOPYRIMIDINE INHIBITORS
  • STAPHYLOCOCCUS-AUREUS
  • N-PHENYLINDOLAMIDES
  • IIA TOPOISOMERASES
  • BUILDING-BLOCKS
  • BROAD-SPECTRUM
  • B GYRB
  • 317 Pharmacy

Cite this

Jakopin, Ziga ; Ilas, Janez ; Barancokova, Michaela ; Brvar, Matjaz ; Tammela, Paivi ; Dolenc, Marija Sollner ; Tomasic, Tihomir ; Kikelj, Danijel. / Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors. In: European Journal of Medicinal Chemistry. 2017 ; Vol. 130. pp. 171-184.
@article{cd5932fba6dd400aa6016dd5575f3c7c,
title = "Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors",
keywords = "1,2,4-Oxadiazoles, DNA gyrase inhibition, Topoisomerase IV inhibition, Antibacterial screening, Computer-aided drug design, ATP-BINDING SITE, TOPOISOMERASE-IV, ANTIBACTERIAL ACTIVITY, PYRROLOPYRIMIDINE INHIBITORS, STAPHYLOCOCCUS-AUREUS, N-PHENYLINDOLAMIDES, IIA TOPOISOMERASES, BUILDING-BLOCKS, BROAD-SPECTRUM, B GYRB, 317 Pharmacy",
author = "Ziga Jakopin and Janez Ilas and Michaela Barancokova and Matjaz Brvar and Paivi Tammela and Dolenc, {Marija Sollner} and Tihomir Tomasic and Danijel Kikelj",
year = "2017",
month = "4",
day = "21",
doi = "10.1016/j.ejmech.2017.02.046",
language = "English",
volume = "130",
pages = "171--184",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER",

}

Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors. / Jakopin, Ziga; Ilas, Janez; Barancokova, Michaela; Brvar, Matjaz; Tammela, Paivi; Dolenc, Marija Sollner; Tomasic, Tihomir; Kikelj, Danijel.

In: European Journal of Medicinal Chemistry, Vol. 130, 21.04.2017, p. 171-184.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

AU - Jakopin, Ziga

AU - Ilas, Janez

AU - Barancokova, Michaela

AU - Brvar, Matjaz

AU - Tammela, Paivi

AU - Dolenc, Marija Sollner

AU - Tomasic, Tihomir

AU - Kikelj, Danijel

PY - 2017/4/21

Y1 - 2017/4/21

KW - 1,2,4-Oxadiazoles

KW - DNA gyrase inhibition

KW - Topoisomerase IV inhibition

KW - Antibacterial screening

KW - Computer-aided drug design

KW - ATP-BINDING SITE

KW - TOPOISOMERASE-IV

KW - ANTIBACTERIAL ACTIVITY

KW - PYRROLOPYRIMIDINE INHIBITORS

KW - STAPHYLOCOCCUS-AUREUS

KW - N-PHENYLINDOLAMIDES

KW - IIA TOPOISOMERASES

KW - BUILDING-BLOCKS

KW - BROAD-SPECTRUM

KW - B GYRB

KW - 317 Pharmacy

U2 - 10.1016/j.ejmech.2017.02.046

DO - 10.1016/j.ejmech.2017.02.046

M3 - Article

VL - 130

SP - 171

EP - 184

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -