Disruption of the SLC26A3-mediated anion transport is associated with male subfertility

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Male subfertility in congenital chloride diarrhea (CLD) was possible after identification of expression of an epithelial Cl-/HCO3-exchanger SLC26A3 in the male reproductive tract and by the observation that adult men with CLD had very few children. A prospective clinical and laboratory study among eight adult Finnish men with CLD revealed constant oligoasthenoteratozoospermia but normal spermatogenesis, high chloride and low pH in seminal plasma, and three spermatoceles, suggesting that male subfertility is a clinical manifestation of CLD and could be caused by an analogous defect in the epithelial Cl-/HCO3- and water transport, as described for the CLD intestine.
Original languageEnglish
JournalFertility and Sterility : official journal of the American Fertility Society
Volume85
Issue number1
Pages (from-to)232-235
Number of pages4
ISSN0015-0282
DOIs
Publication statusPublished - 2006
MoE publication typeA1 Journal article-refereed

Fields of Science

  • CONGENITAL CHLORIDE DIARRHEA
  • DEPENDENT HCO3-TRANSPORT
  • CYSTIC-FIBROSIS
  • ADENOMA DRA
  • CL-/HCO3-EXCHANGE
  • GENE
  • CFTR
  • MUTATIONS
  • DISEASE
  • DOMAIN
  • 312 Clinical medicine
  • Obstetrics and gynecology

Cite this