Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

Jing Chen; Jonas Bacelis; Pol Sole-Navais; Amit Srivastava; Julius Juodakis; Amy Rouse; Mikko Hallman; Kari Teramo; Mads Melbye; Bjarke Feenstra; Rachel M. Freathy; George Davey Smith; Deborah A. Lawlor; Jeffrey C. Murray; Scott M. Williams; Bo Jacobsson; Louis J. Muglia; Ge Zhang

doi:10.1371/journal.pmed.1003305

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

Jing Chen, Jonas Bacelis, Pol Sole-Navais, Amit Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M. Freathy, George Davey Smith, Deborah A. Lawlor, Jeffrey C. Murray, Scott M. Williams, Bo Jacobsson, Louis J. Muglia, Ge Zhang

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	1003305
Journal	PLoS Medicine
Volume	17
Issue number	8
Number of pages	28
ISSN	1549-1277
DOIs	https://doi.org/10.1371/journal.pmed.1003305
Publication status	Published - 25 Aug 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

1184 Genetics, developmental biology, physiology
3123 Gynaecology and paediatrics
DEVELOPMENTAL ORIGINS
BLOOD-PRESSURE
RISK-FACTORS
WEIGHT
PREGNANCY
DISEASE
TRAITS
DETERMINANTS
HYPOTHESIS
OBESITY

Access to Document

10.1371/journal.pmed.1003305

journal.pmed.1003305Final published version, 2.44 MBLicence: CC BY

Cite this

Chen, J., Bacelis, J., Sole-Navais, P., Srivastava, A., Juodakis, J., Rouse, A., Hallman, M., Teramo, K., Melbye, M., Feenstra, B., Freathy, R. M., Smith, G. D., Lawlor, D. A., Murray, J. C., Williams, S. M., Jacobsson, B., Muglia, L. J., & Zhang, G. (2020). Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs. PLoS Medicine, 17(8), [1003305]. https://doi.org/10.1371/journal.pmed.1003305

@article{74dad2f2824b41d8a98c939d8d4afcaf,

title = "Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs",

keywords = "1184 Genetics, developmental biology, physiology, 3123 Gynaecology and paediatrics, DEVELOPMENTAL ORIGINS, BLOOD-PRESSURE, RISK-FACTORS, WEIGHT, PREGNANCY, DISEASE, TRAITS, DETERMINANTS, HYPOTHESIS, OBESITY",

author = "Jing Chen and Jonas Bacelis and Pol Sole-Navais and Amit Srivastava and Julius Juodakis and Amy Rouse and Mikko Hallman and Kari Teramo and Mads Melbye and Bjarke Feenstra and Freathy, {Rachel M.} and Smith, {George Davey} and Lawlor, {Deborah A.} and Murray, {Jeffrey C.} and Williams, {Scott M.} and Bo Jacobsson and Muglia, {Louis J.} and Ge Zhang",

year = "2020",

month = aug,

day = "25",

doi = "10.1371/journal.pmed.1003305",

language = "English",

volume = "17",

journal = "PLoS Medicine",

issn = "1549-1277",

publisher = "PUBLIC LIBRARY OF SCIENCE",

number = "8",

}

Chen, J, Bacelis, J, Sole-Navais, P, Srivastava, A, Juodakis, J, Rouse, A, Hallman, M, Teramo, K, Melbye, M, Feenstra, B, Freathy, RM, Smith, GD, Lawlor, DA, Murray, JC, Williams, SM, Jacobsson, B, Muglia, LJ & Zhang, G 2020, 'Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs', PLoS Medicine, vol. 17, no. 8, 1003305. https://doi.org/10.1371/journal.pmed.1003305

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs. / Chen, Jing; Bacelis, Jonas; Sole-Navais, Pol et al.

In: PLoS Medicine, Vol. 17, No. 8, 1003305, 25.08.2020.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

AU - Chen, Jing

AU - Bacelis, Jonas

AU - Sole-Navais, Pol

AU - Srivastava, Amit

AU - Juodakis, Julius

AU - Rouse, Amy

AU - Hallman, Mikko

AU - Teramo, Kari

AU - Melbye, Mads

AU - Feenstra, Bjarke

AU - Freathy, Rachel M.

AU - Smith, George Davey

AU - Lawlor, Deborah A.

AU - Murray, Jeffrey C.

AU - Williams, Scott M.

AU - Jacobsson, Bo

AU - Muglia, Louis J.

AU - Zhang, Ge

PY - 2020/8/25

Y1 - 2020/8/25

KW - 1184 Genetics, developmental biology, physiology

KW - 3123 Gynaecology and paediatrics

KW - DEVELOPMENTAL ORIGINS

KW - BLOOD-PRESSURE

KW - RISK-FACTORS

KW - WEIGHT

KW - PREGNANCY

KW - DISEASE

KW - TRAITS

KW - DETERMINANTS

KW - HYPOTHESIS

KW - OBESITY

U2 - 10.1371/journal.pmed.1003305

DO - 10.1371/journal.pmed.1003305

M3 - Article

VL - 17

JO - PLoS Medicine

JF - PLoS Medicine

SN - 1549-1277

IS - 8

M1 - 1003305

ER -

Chen J, Bacelis J, Sole-Navais P, Srivastava A, Juodakis J, Rouse A et al. Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs. PLoS Medicine. 2020 Aug 25;17(8):1003305. doi: 10.1371/journal.pmed.1003305