DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

Satu Mäki-Nevala; Satu Valo; Ari Ristimaki; Virinder Sarhadi; Sakari Knuutila; Minna Nyström; Laura Renkonen-Sinisalo; Anna Lepistö; Jukka-Pekka Mecklin; Päivi Peltomäki

doi:10.1016/j.ebiom.2018.12.018

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

Satu Mäki-Nevala, Satu Valo, Ari Ristimaki, Virinder Sarhadi, Sakari Knuutila, Minna Nyström, Laura Renkonen-Sinisalo, Anna Lepistö, Jukka-Pekka Mecklin, Päivi Peltomäki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	EBioMedicine
Volume	39
Pages (from-to)	280-291
Number of pages	12
ISSN	2352-3964
DOIs	https://doi.org/10.1016/j.ebiom.2018.12.018
Publication status	Published - Jan 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

Lynch syndrome
Colorectal adenoma
DNA methylation
DNA mismatch repair
UNE-1 methylation
Mutation
Tumotigenesis
Tumor suppressor
MICROSATELLITE INSTABILITY
COLORECTAL ADENOMAS
BRAF MUTATION
COPY NUMBER
CANCER
GENE
DEFICIENCY
PHENOTYPE
TUMORS
HYPOMETHYLATION
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1016/j.ebiom.2018.12.018Licence: CC BY-NC-ND

1-s2.0-S2352396418305954-mainFinal published version, 546 KBLicence: CC BY-NC-ND

Cite this

Mäki-Nevala, S., Valo, S., Ristimaki, A., Sarhadi, V., Knuutila, S., Nyström, M., Renkonen-Sinisalo, L., Lepistö, A., Mecklin, J.-P., & Peltomäki, P. (2019). DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression. EBioMedicine, 39, 280-291. https://doi.org/10.1016/j.ebiom.2018.12.018

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title = "DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression",

keywords = "Lynch syndrome, Colorectal adenoma, DNA methylation, DNA mismatch repair, UNE-1 methylation, Mutation, Tumotigenesis, Tumor suppressor, MICROSATELLITE INSTABILITY, COLORECTAL ADENOMAS, BRAF MUTATION, COPY NUMBER, CANCER, GENE, DEFICIENCY, PHENOTYPE, TUMORS, HYPOMETHYLATION, 3111 Biomedicine, 3121 General medicine, internal medicine and other clinical medicine",

author = "Satu M{\"a}ki-Nevala and Satu Valo and Ari Ristimaki and Virinder Sarhadi and Sakari Knuutila and Minna Nystr{\"o}m and Laura Renkonen-Sinisalo and Anna Lepist{\"o} and Jukka-Pekka Mecklin and P{\"a}ivi Peltom{\"a}ki",

year = "2019",

month = jan,

doi = "10.1016/j.ebiom.2018.12.018",

language = "English",

volume = "39",

pages = "280--291",

journal = "EBioMedicine",

issn = "2352-3964",

publisher = "Elsevier Scientific Publ. Co",

}

Mäki-Nevala, S, Valo, S, Ristimaki, A, Sarhadi, V, Knuutila, S , Nyström, M, Renkonen-Sinisalo, L, Lepistö, A, Mecklin, J-P & Peltomäki, P 2019, 'DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression', EBioMedicine, vol. 39, pp. 280-291. https://doi.org/10.1016/j.ebiom.2018.12.018

TY - JOUR

T1 - DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

AU - Mäki-Nevala, Satu

AU - Valo, Satu

AU - Ristimaki, Ari

AU - Sarhadi, Virinder

AU - Knuutila, Sakari

AU - Nyström, Minna

AU - Renkonen-Sinisalo, Laura

AU - Lepistö, Anna

AU - Mecklin, Jukka-Pekka

AU - Peltomäki, Päivi

PY - 2019/1

Y1 - 2019/1

KW - Lynch syndrome

KW - Colorectal adenoma

KW - DNA methylation

KW - DNA mismatch repair

KW - UNE-1 methylation

KW - Mutation

KW - Tumotigenesis

KW - Tumor suppressor

KW - MICROSATELLITE INSTABILITY

KW - COLORECTAL ADENOMAS

KW - BRAF MUTATION

KW - COPY NUMBER

KW - CANCER

KW - GENE

KW - DEFICIENCY

KW - PHENOTYPE

KW - TUMORS

KW - HYPOMETHYLATION

KW - 3111 Biomedicine

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1016/j.ebiom.2018.12.018

DO - 10.1016/j.ebiom.2018.12.018

M3 - Article

SN - 2352-3964

VL - 39

SP - 280

EP - 291

JO - EBioMedicine

JF - EBioMedicine

ER -