DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression

Satu Mäki-Nevala, Satu Valo, Ari Ristimaki, Virinder Sarhadi, Sakari Knuutila, Minna Nyström, Laura Renkonen-Sinisalo, Anna Lepistö, Jukka-Pekka Mecklin, Päivi Peltomäki

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalEBioMedicine
Volume39
Pages (from-to)280-291
Number of pages12
ISSN2352-3964
DOIs
Publication statusPublished - Jan 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Lynch syndrome
  • Colorectal adenoma
  • DNA methylation
  • DNA mismatch repair
  • UNE-1 methylation
  • Mutation
  • Tumotigenesis
  • Tumor suppressor
  • MICROSATELLITE INSTABILITY
  • COLORECTAL ADENOMAS
  • BRAF MUTATION
  • COPY NUMBER
  • CANCER
  • GENE
  • DEFICIENCY
  • PHENOTYPE
  • TUMORS
  • HYPOMETHYLATION
  • 3111 Biomedicine
  • 3121 Internal medicine

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