Abstract

Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.

Original languageEnglish
JournalHistopathology
Volume74
Issue number4
Pages (from-to)536-544
Number of pages9
ISSN0309-0167
DOIs
Publication statusPublished - Mar 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 111 Mathematics
  • 3111 Biomedicine
  • 3121 Internal medicine
  • BIOPSY
  • MARKER
  • PROGNOSIS
  • TREATMENT PLANNING
  • TUMOUR BUDDING
  • SQUAMOUS-CELL CARCINOMA
  • LYMPH-NODE METASTASIS
  • PREOPERATIVE BIOPSIES
  • PROGNOSTIC VALUE
  • POOR-PROGNOSIS
  • CANCER
  • STAGE
  • PREDICTS
  • SPECIMENS
  • TONGUE

Cite this

@article{b3279c6db3e64132a6a94d65decc5738,
title = "Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance?: A Systematic Review",
abstract = "Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.",
keywords = "111 Mathematics, 3111 Biomedicine, 3121 Internal medicine, BIOPSY, MARKER, PROGNOSIS, TREATMENT PLANNING, TUMOUR BUDDING, SQUAMOUS-CELL CARCINOMA, LYMPH-NODE METASTASIS, PREOPERATIVE BIOPSIES, PROGNOSTIC VALUE, POOR-PROGNOSIS, CANCER, STAGE, PREDICTS, SPECIMENS, TONGUE",
author = "Alhadi Almangush and Omar Youssef and Matti Pirinen and Jari Sundstr{\"o}m and Ilmo Leivo and M{\"a}kitie, {Antti A.}",
year = "2019",
month = "3",
doi = "10.1111/his.13793",
language = "English",
volume = "74",
pages = "536--544",
journal = "Histopathology",
issn = "0309-0167",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "4",

}

Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance? A Systematic Review. / Almangush, Alhadi; Youssef, Omar; Pirinen, Matti ; Sundström, Jari; Leivo, Ilmo; Mäkitie, Antti A.

In: Histopathology, Vol. 74, No. 4, 03.2019, p. 536-544.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance?

T2 - A Systematic Review

AU - Almangush, Alhadi

AU - Youssef, Omar

AU - Pirinen, Matti

AU - Sundström, Jari

AU - Leivo, Ilmo

AU - Mäkitie, Antti A.

PY - 2019/3

Y1 - 2019/3

N2 - Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.

AB - Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.

KW - 111 Mathematics

KW - 3111 Biomedicine

KW - 3121 Internal medicine

KW - BIOPSY

KW - MARKER

KW - PROGNOSIS

KW - TREATMENT PLANNING

KW - TUMOUR BUDDING

KW - SQUAMOUS-CELL CARCINOMA

KW - LYMPH-NODE METASTASIS

KW - PREOPERATIVE BIOPSIES

KW - PROGNOSTIC VALUE

KW - POOR-PROGNOSIS

KW - CANCER

KW - STAGE

KW - PREDICTS

KW - SPECIMENS

KW - TONGUE

U2 - 10.1111/his.13793

DO - 10.1111/his.13793

M3 - Review Article

VL - 74

SP - 536

EP - 544

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 4

ER -