Abstract

Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.

Original languageEnglish
JournalHistopathology
Volume74
Issue number4
Pages (from-to)536-544
Number of pages9
ISSN0309-0167
DOIs
Publication statusPublished - Mar 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 111 Mathematics
  • 3111 Biomedicine
  • 3121 Internal medicine
  • BIOPSY
  • MARKER
  • PROGNOSIS
  • TREATMENT PLANNING
  • TUMOUR BUDDING
  • SQUAMOUS-CELL CARCINOMA
  • LYMPH-NODE METASTASIS
  • PREOPERATIVE BIOPSIES
  • PROGNOSTIC VALUE
  • POOR-PROGNOSIS
  • CANCER
  • STAGE
  • PREDICTS
  • SPECIMENS
  • TONGUE

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