Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake, sustained release, and combination therapy

Chang-Fang Wang; Ermei M. Mäkilä; Martti H. Kaasalainen; Marja V. Hagström; Jarno J. Salonen; Jouni T. Hirvonen; Hélder A. Santos

doi:10.1016/j.actbio.2015.01.021

Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake, sustained release, and combination therapy

Chang-Fang Wang, Ermei M. Mäkilä, Martti H. Kaasalainen, Marja V. Hagström, Jarno J. Salonen, Jouni T. Hirvonen, Hélder A. Santos

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Acta Biomaterialia
Volume	16
Pages (from-to)	206-214
Number of pages	9
ISSN	1742-7061
DOIs	https://doi.org/10.1016/j.actbio.2015.01.021
Publication status	Published - 1 Apr 2015
MoE publication type	A1 Journal article-refereed

Fields of Science

Intracellular uptake
Sustained drug release
Combination therapy
Porous silicon nanoparticles
Methotrexate/Sorafenib
REFRACTORY SOLID TUMORS
IN-VIVO
ANTITUMOR-ACTIVITY
DIHYDROFOLATE-REDUCTASE
DENDRIMER-METHOTREXATE
SURFACE-CHEMISTRY
CANCER-THERAPY
PHASE-I
MICROPARTICLES
MECHANISMS
216 Materials engineering
3111 Biomedicine
317 Pharmacy

Access to Document

10.1016/j.actbio.2015.01.021

http://www.sciencedirect.com/science/article/pii/S1742706115000318

Cite this

@article{dbeb0f5cdb9846daacc3f9bc6d39f487,

title = "Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake, sustained release, and combination therapy",

keywords = "Intracellular uptake, Sustained drug release, Combination therapy, Porous silicon nanoparticles, Methotrexate/Sorafenib, REFRACTORY SOLID TUMORS, IN-VIVO, ANTITUMOR-ACTIVITY, DIHYDROFOLATE-REDUCTASE, DENDRIMER-METHOTREXATE, SURFACE-CHEMISTRY, CANCER-THERAPY, PHASE-I, MICROPARTICLES, MECHANISMS, 216 Materials engineering, 3111 Biomedicine, 317 Pharmacy",

author = "Chang-Fang Wang and M{\"a}kil{\"a}, {Ermei M.} and Kaasalainen, {Martti H.} and Hagstr{\"o}m, {Marja V.} and Salonen, {Jarno J.} and Hirvonen, {Jouni T.} and Santos, {H{\'e}lder A.}",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.actbio.2015.01.021",

language = "English",

volume = "16",

pages = "206--214",

journal = "Acta Biomaterialia",

issn = "1742-7061",

publisher = "Acta Materialia Inc",

}

TY - JOUR

T1 - Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake, sustained release, and combination therapy

AU - Wang, Chang-Fang

AU - Mäkilä, Ermei M.

AU - Kaasalainen, Martti H.

AU - Hagström, Marja V.

AU - Salonen, Jarno J.

AU - Hirvonen, Jouni T.

AU - Santos, Hélder A.

PY - 2015/4/1

Y1 - 2015/4/1

KW - Intracellular uptake

KW - Sustained drug release

KW - Combination therapy

KW - Porous silicon nanoparticles

KW - Methotrexate/Sorafenib

KW - REFRACTORY SOLID TUMORS

KW - IN-VIVO

KW - ANTITUMOR-ACTIVITY

KW - DIHYDROFOLATE-REDUCTASE

KW - DENDRIMER-METHOTREXATE

KW - SURFACE-CHEMISTRY

KW - CANCER-THERAPY

KW - PHASE-I

KW - MICROPARTICLES

KW - MECHANISMS

KW - 216 Materials engineering

KW - 3111 Biomedicine

KW - 317 Pharmacy

U2 - 10.1016/j.actbio.2015.01.021

DO - 10.1016/j.actbio.2015.01.021

M3 - Article

SN - 1742-7061

VL - 16

SP - 206

EP - 214

JO - Acta Biomaterialia

JF - Acta Biomaterialia

ER -