DUX4 is a multifunctional factor priming human embryonic genome activation

Sanna Vuoristo; Shruti Bhagat; Christel Hyden-Granskog; Masahito Yoshihara; Lisa Gawriyski; Eeva-Mari Jouhilahti; Vipin Ranga; Mahlet Tamirat; Mikko Huhtala; Ida Kirjanov; Sonja Nykänen; Kaarel Krjutskov; Anastassius Damdimopoulos; Jere Weltner; Kosuke Hashimoto; Gaelle Recher; Sini Ezer; Priit Paluoja; Pauliina Paloviita; Yujiro Takegami; Ai Kanemaru; Karolina Lundin; Tomi T. Airenne; Timo Otonkoski; Juha S. Tapanainen; Hideya Kawaji; Yasuhiro Murakawa; Thomas R. Burglin; Markku Varjosalo; Mark S. Johnson; Timo Tuuri; Shintaro Katayama; Juha Kere

doi:10.1016/j.isci.2022.104137

DUX4 is a multifunctional factor priming human embryonic genome activation

Sanna Vuoristo, Shruti Bhagat, Christel Hyden-Granskog, Masahito Yoshihara, Lisa Gawriyski, Eeva-Mari Jouhilahti, Vipin Ranga, Mahlet Tamirat, Mikko Huhtala, Ida Kirjanov, Sonja Nykänen, Kaarel Krjutskov, Anastassius Damdimopoulos, Jere Weltner, Kosuke Hashimoto, Gaelle Recher, Sini Ezer, Priit Paluoja, Pauliina Paloviita, Yujiro TakegamiAi Kanemaru, Karolina Lundin, Tomi T. Airenne, Timo Otonkoski, Juha S. Tapanainen, Hideya Kawaji, Yasuhiro Murakawa, Thomas R. Burglin, Markku Varjosalo, Mark S. Johnson, Timo Tuuri, Shintaro Katayama, Juha Kere

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	104137
Journal	iScience
Volume	25
Issue number	4
Number of pages	29
ISSN	2589-0042
DOIs	https://doi.org/10.1016/j.isci.2022.104137
Publication status	Published - 15 Apr 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

1182 Biochemistry, cell and molecular biology
Human preimplantation embryos
Differential expression analysis
Single-cell transcriptome
Long terminal repeats
Gene-expression
Zygotic genome
Kix domain
Transactivation domain
Transposable elements
Protein-structure

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10.1016/j.isci.2022.104137Licence: CC BY

1-s2.0-S2589004222004072-mainFinal published version, 4.11 MBLicence: CC BY

Cite this

Vuoristo, S., Bhagat, S., Hyden-Granskog, C., Yoshihara, M., Gawriyski, L., Jouhilahti, E.-M., Ranga, V., Tamirat, M., Huhtala, M., Kirjanov, I., Nykänen, S., Krjutskov, K., Damdimopoulos, A., Weltner, J., Hashimoto, K., Recher, G., Ezer, S., Paluoja, P., Paloviita, P., ... Kere, J. (2022). DUX4 is a multifunctional factor priming human embryonic genome activation. iScience, 25(4), Article 104137. https://doi.org/10.1016/j.isci.2022.104137

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title = "DUX4 is a multifunctional factor priming human embryonic genome activation",

keywords = "1182 Biochemistry, cell and molecular biology, Human preimplantation embryos, Differential expression analysis, Single-cell transcriptome, Long terminal repeats, Gene-expression, Zygotic genome, Kix domain, Transactivation domain, Transposable elements, Protein-structure",

author = "Sanna Vuoristo and Shruti Bhagat and Christel Hyden-Granskog and Masahito Yoshihara and Lisa Gawriyski and Eeva-Mari Jouhilahti and Vipin Ranga and Mahlet Tamirat and Mikko Huhtala and Ida Kirjanov and Sonja Nyk{\"a}nen and Kaarel Krjutskov and Anastassius Damdimopoulos and Jere Weltner and Kosuke Hashimoto and Gaelle Recher and Sini Ezer and Priit Paluoja and Pauliina Paloviita and Yujiro Takegami and Ai Kanemaru and Karolina Lundin and Airenne, {Tomi T.} and Timo Otonkoski and Tapanainen, {Juha S.} and Hideya Kawaji and Yasuhiro Murakawa and Burglin, {Thomas R.} and Markku Varjosalo and Johnson, {Mark S.} and Timo Tuuri and Shintaro Katayama and Juha Kere",

year = "2022",

month = apr,

day = "15",

doi = "10.1016/j.isci.2022.104137",

language = "English",

volume = "25",

journal = "iScience",

issn = "2589-0042",

publisher = "Cell Press Elsevier Inc.",

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Vuoristo, S, Bhagat, S, Hyden-Granskog, C, Yoshihara, M, Gawriyski, L, Jouhilahti, E-M, Ranga, V, Tamirat, M, Huhtala, M, Kirjanov, I, Nykänen, S, Krjutskov, K, Damdimopoulos, A, Weltner, J, Hashimoto, K, Recher, G, Ezer, S, Paluoja, P, Paloviita, P, Takegami, Y, Kanemaru, A, Lundin, K, Airenne, TT, Otonkoski, T , Tapanainen, JS, Kawaji, H, Murakawa, Y, Burglin, TR, Varjosalo, M, Johnson, MS, Tuuri, T, Katayama, S & Kere, J 2022, 'DUX4 is a multifunctional factor priming human embryonic genome activation', iScience, vol. 25, no. 4, 104137. https://doi.org/10.1016/j.isci.2022.104137

TY - JOUR

T1 - DUX4 is a multifunctional factor priming human embryonic genome activation

AU - Vuoristo, Sanna

AU - Bhagat, Shruti

AU - Hyden-Granskog, Christel

AU - Yoshihara, Masahito

AU - Gawriyski, Lisa

AU - Jouhilahti, Eeva-Mari

AU - Ranga, Vipin

AU - Tamirat, Mahlet

AU - Huhtala, Mikko

AU - Kirjanov, Ida

AU - Nykänen, Sonja

AU - Krjutskov, Kaarel

AU - Damdimopoulos, Anastassius

AU - Weltner, Jere

AU - Hashimoto, Kosuke

AU - Recher, Gaelle

AU - Ezer, Sini

AU - Paluoja, Priit

AU - Paloviita, Pauliina

AU - Takegami, Yujiro

AU - Kanemaru, Ai

AU - Lundin, Karolina

AU - Airenne, Tomi T.

AU - Otonkoski, Timo

AU - Tapanainen, Juha S.

AU - Kawaji, Hideya

AU - Murakawa, Yasuhiro

AU - Burglin, Thomas R.

AU - Varjosalo, Markku

AU - Johnson, Mark S.

AU - Tuuri, Timo

AU - Katayama, Shintaro

AU - Kere, Juha

PY - 2022/4/15

Y1 - 2022/4/15

KW - 1182 Biochemistry, cell and molecular biology

KW - Human preimplantation embryos

KW - Differential expression analysis

KW - Single-cell transcriptome

KW - Long terminal repeats

KW - Gene-expression

KW - Zygotic genome

KW - Kix domain

KW - Transactivation domain

KW - Transposable elements

KW - Protein-structure

U2 - 10.1016/j.isci.2022.104137

DO - 10.1016/j.isci.2022.104137

M3 - Article

SN - 2589-0042

VL - 25

JO - iScience

JF - iScience

IS - 4

M1 - 104137

ER -