Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach

Research output: Contribution to journalReview Articlepeer-review

Abstract

The colonisation and development of the gut microbiota has been implicated in paediatric metabolic disorders via its powerful effect on host metabolic and immune homeostasis. Here we summarise the evidence from human studies on the early gut microbiota and paediatric overweight and obesity. Manipulation of the early gut microbiota may represent a promising target for countering the burgeoning metabolic disorders in the paediatric population, provided the assembly patterns of microbiota and their health consequences can be decoded. Therefore, in this review, we pay particular attention to the important ecological drivers affecting the community dynamics of the early gut microbiota. We then discuss the knowledge gaps in commonly studied exposures linking the gut microbiota to metabolic disorders, especially regarding maternal factors and antibiotic use. This review also attempts to give directions for future studies aiming to identify predictive and corrective measures for paediatric metabolic disorders based on the gut microbiota.
Original languageEnglish
Article number103475
JournalEBioMedicine
Volume69
Number of pages9
ISSN2352-3964
DOIs
Publication statusPublished - 10 Jul 2021
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3121 General medicine, internal medicine and other clinical medicine
  • HUMAN-MILK OLIGOSACCHARIDES
  • INTESTINAL MICROBIOTA
  • MATERNAL OBESITY
  • RISK
  • OVERWEIGHT
  • DYNAMICS
  • IMPACT
  • BIFIDOBACTERIA
  • COLONIZATION
  • TRANSMISSION

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