Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice

Zydrune Polianskyte-Prause; Tuomas A. Tolvanen; Sonja Lindfors; Kanta Kon; Laura C. Hautala; Hong Wang; Tsutomu Wada; Hiroshi Tsuneki; Toshiyasu Sasaoka; Sanna Lehtonen

doi:10.7150/ijbs.66314

Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice

Zydrune Polianskyte-Prause, Tuomas A. Tolvanen, Sonja Lindfors, Kanta Kon, Laura C. Hautala, Hong Wang, Tsutomu Wada, Hiroshi Tsuneki, Toshiyasu Sasaoka, Sanna Lehtonen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	International Journal of Biological Sciences
Volume	18
Issue number	5
Pages (from-to)	1852-1864
Number of pages	13
ISSN	1449-2288
DOIs	https://doi.org/10.7150/ijbs.66314
Publication status	Published - 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

inflammation
lipid phosphatase
oxidative stress
type 2 diabetes
insulin resistance
SH2-CONTAINING INOSITOL 5'-PHOSPHATASE-2
GLUCOSE-METABOLISM
SELENOORGANIC COMPOUND
ROS PRODUCTION
LIPID PHOSPHATASES
NADPH OXIDASE
NITRIC-OXIDE
LIVER-INJURY
RAT
PATHWAY
3111 Biomedicine
1182 Biochemistry, cell and molecular biology

Access to Document

10.7150/ijbs.66314

v18p1852Final published version, 1.38 MBLicence: CC BY

Cite this

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Kon, K., Hautala, L. C., Wang, H., Wada, T., Tsuneki, H., Sasaoka, T., & Lehtonen, S. (2022). Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice. International Journal of Biological Sciences, 18(5), 1852-1864. https://doi.org/10.7150/ijbs.66314

@article{4d1ba4a601ed4a079c3a6ad412af5856,

title = "Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice",

keywords = "inflammation, lipid phosphatase, oxidative stress, type 2 diabetes, insulin resistance, SH2-CONTAINING INOSITOL 5'-PHOSPHATASE-2, GLUCOSE-METABOLISM, SELENOORGANIC COMPOUND, ROS PRODUCTION, LIPID PHOSPHATASES, NADPH OXIDASE, NITRIC-OXIDE, LIVER-INJURY, RAT, PATHWAY, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology",

author = "Zydrune Polianskyte-Prause and Tolvanen, {Tuomas A.} and Sonja Lindfors and Kanta Kon and Hautala, {Laura C.} and Hong Wang and Tsutomu Wada and Hiroshi Tsuneki and Toshiyasu Sasaoka and Sanna Lehtonen",

year = "2022",

doi = "10.7150/ijbs.66314",

language = "English",

volume = "18",

pages = "1852--1864",

journal = "International Journal of Biological Sciences",

issn = "1449-2288",

publisher = "IVYSPRING INTERNATIONAL PUBLISHER",

number = "5",

}

Polianskyte-Prause, Z, Tolvanen, TA, Lindfors, S, Kon, K, Hautala, LC , Wang, H, Wada, T, Tsuneki, H, Sasaoka, T & Lehtonen, S 2022, 'Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice', International Journal of Biological Sciences, vol. 18, no. 5, pp. 1852-1864. https://doi.org/10.7150/ijbs.66314

Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice. / Polianskyte-Prause, Zydrune; Tolvanen, Tuomas A.; Lindfors, Sonja et al.
In: International Journal of Biological Sciences, Vol. 18, No. 5, 2022, p. 1852-1864.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice

AU - Polianskyte-Prause, Zydrune

AU - Tolvanen, Tuomas A.

AU - Lindfors, Sonja

AU - Kon, Kanta

AU - Hautala, Laura C.

AU - Wang, Hong

AU - Wada, Tsutomu

AU - Tsuneki, Hiroshi

AU - Sasaoka, Toshiyasu

AU - Lehtonen, Sanna

PY - 2022

Y1 - 2022

KW - inflammation

KW - lipid phosphatase

KW - oxidative stress

KW - type 2 diabetes

KW - insulin resistance

KW - SH2-CONTAINING INOSITOL 5'-PHOSPHATASE-2

KW - GLUCOSE-METABOLISM

KW - SELENOORGANIC COMPOUND

KW - ROS PRODUCTION

KW - LIPID PHOSPHATASES

KW - NADPH OXIDASE

KW - NITRIC-OXIDE

KW - LIVER-INJURY

KW - RAT

KW - PATHWAY

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.7150/ijbs.66314

DO - 10.7150/ijbs.66314

M3 - Article

SN - 1449-2288

VL - 18

SP - 1852

EP - 1864

JO - International Journal of Biological Sciences

JF - International Journal of Biological Sciences

IS - 5

ER -