Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity

Alexander N. Shikov; Olga N. Pozharitskaya; Marina N. Makarova; Maria A. Kovaleva; Into Laakso; H. J. Damien Dorman; Raimo Hiltunen; Valery G. Makarov; Bertalan  Galambosi

doi:10.1016/j.phymed.2012.09.019

Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity

Alexander N. Shikov, Olga N. Pozharitskaya, Marina N. Makarova, Maria A. Kovaleva, Into Laakso, H. J. Damien Dorman, Raimo Hiltunen, Valery G. Makarov, Bertalan Galambosi

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Abstract

The objective of this study was to evaluate the feeding behavior and weight gain in rats with high-caloric diet-induced obesity that are treated with Bergenia crassifolia black and fermented leaves extracts. The daily dietary intake of all treated animals was reduced to 40% compared with the control group on day 22 of the experiment. A significant improvement in glucose tolerance was noted after 7 days of treatment with the Bergenia extracts. In rats treated with an extract of black leaves for 7 days, a significant reduction in the serum triglyceride level, 45% (p < 0.05), compared with the control group was observed. However, the treatment did not affect the cholesterol level. Our results provide evidence for the potential use of B. crassifolia as an appetite and energy intake suppressant.

Original language	English
Journal	Phytomedicine
Volume	19
Issue number	14
Pages (from-to)	1250–1255
Number of pages	6
ISSN	0944-7113
DOIs	https://doi.org/10.1016/j.phymed.2012.09.019
Publication status	Published - Sept 2012
MoE publication type	A1 Journal article-refereed

Fields of Science

317 Pharmacy
Bergenia
Cafeteria diet
Glucose tolerance test
Obesity
Rats

Access to Document

10.1016/j.phymed.2012.09.019

Cite this

@article{6d12301f32634f17b7772b9fd5a6778e,

title = "Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity",

abstract = "The objective of this study was to evaluate the feeding behavior and weight gain in rats with high-caloric diet-induced obesity that are treated with Bergenia crassifolia black and fermented leaves extracts. The daily dietary intake of all treated animals was reduced to 40% compared with the control group on day 22 of the experiment. A significant improvement in glucose tolerance was noted after 7 days of treatment with the Bergenia extracts. In rats treated with an extract of black leaves for 7 days, a significant reduction in the serum triglyceride level, 45% (p < 0.05), compared with the control group was observed. However, the treatment did not affect the cholesterol level. Our results provide evidence for the potential use of B. crassifolia as an appetite and energy intake suppressant.",

keywords = "317 Pharmacy, Bergenia , Cafeteria diet, Glucose tolerance test , Obesity, Rats, liquid chromatography",

author = "Shikov, {Alexander N.} and Pozharitskaya, {Olga N.} and Makarova, {Marina N.} and Kovaleva, {Maria A.} and Into Laakso and Dorman, {H. J. Damien} and Raimo Hiltunen and Makarov, {Valery G.} and Bertalan Galambosi",

year = "2012",

month = sep,

doi = "10.1016/j.phymed.2012.09.019",

language = "English",

volume = "19 ",

pages = "1250–1255",

journal = "Phytomedicine",

issn = "0944-7113",

publisher = "Elsevier GmbH",

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TY - JOUR

T1 - Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity

AU - Shikov, Alexander N.

AU - Pozharitskaya, Olga N.

AU - Makarova, Marina N.

AU - Kovaleva, Maria A.

AU - Laakso, Into

AU - Dorman, H. J. Damien

AU - Hiltunen, Raimo

AU - Makarov, Valery G.

AU - Galambosi, Bertalan

PY - 2012/9

Y1 - 2012/9

N2 - The objective of this study was to evaluate the feeding behavior and weight gain in rats with high-caloric diet-induced obesity that are treated with Bergenia crassifolia black and fermented leaves extracts. The daily dietary intake of all treated animals was reduced to 40% compared with the control group on day 22 of the experiment. A significant improvement in glucose tolerance was noted after 7 days of treatment with the Bergenia extracts. In rats treated with an extract of black leaves for 7 days, a significant reduction in the serum triglyceride level, 45% (p < 0.05), compared with the control group was observed. However, the treatment did not affect the cholesterol level. Our results provide evidence for the potential use of B. crassifolia as an appetite and energy intake suppressant.

AB - The objective of this study was to evaluate the feeding behavior and weight gain in rats with high-caloric diet-induced obesity that are treated with Bergenia crassifolia black and fermented leaves extracts. The daily dietary intake of all treated animals was reduced to 40% compared with the control group on day 22 of the experiment. A significant improvement in glucose tolerance was noted after 7 days of treatment with the Bergenia extracts. In rats treated with an extract of black leaves for 7 days, a significant reduction in the serum triglyceride level, 45% (p < 0.05), compared with the control group was observed. However, the treatment did not affect the cholesterol level. Our results provide evidence for the potential use of B. crassifolia as an appetite and energy intake suppressant.

KW - 317 Pharmacy

KW - Bergenia

KW - Cafeteria diet

KW - Glucose tolerance test

KW - Obesity

KW - Rats

KW - liquid chromatography

U2 - 10.1016/j.phymed.2012.09.019

DO - 10.1016/j.phymed.2012.09.019

M3 - Article

SN - 0944-7113

VL - 19

SP - 1250

EP - 1255

JO - Phytomedicine

JF - Phytomedicine

IS - 14

ER -