Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug‐inclusion processes via electrospinning could be employed to achieve programmed, multi‐staged, or stimuli‐triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drug‐eluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.
LanguageEnglish
JournalAdvanced Functional Materials
Volume29
Issue number2
Pages1802852
Number of pages35
ISSN1616-301X
DOIs
Publication statusPublished - 10 Jan 2019
MoE publication typeA2 Review article in a scientific journal

Cite this

@article{3665c84f22564015ad18ce1b75a0adaa,
title = "Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy",
abstract = "The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug‐inclusion processes via electrospinning could be employed to achieve programmed, multi‐staged, or stimuli‐triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drug‐eluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.",
author = "Yaping Ding and Wei Li and Feng Zhang and Zehua Liu and {Zanjanizadeh Ezazi}, Nazanin and Dongfei Liu and {Almeida Santos}, Helder",
year = "2019",
month = "1",
day = "10",
doi = "10.1002/adfm.201802852",
language = "English",
volume = "29",
pages = "1802852",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH",
number = "2",

}

TY - JOUR

T1 - Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

AU - Ding, Yaping

AU - Li, Wei

AU - Zhang, Feng

AU - Liu, Zehua

AU - Zanjanizadeh Ezazi, Nazanin

AU - Liu, Dongfei

AU - Almeida Santos, Helder

PY - 2019/1/10

Y1 - 2019/1/10

N2 - The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug‐inclusion processes via electrospinning could be employed to achieve programmed, multi‐staged, or stimuli‐triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drug‐eluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

AB - The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug‐inclusion processes via electrospinning could be employed to achieve programmed, multi‐staged, or stimuli‐triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drug‐eluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

UR - https://onlinelibrary.wiley.com/journal/16163028

U2 - 10.1002/adfm.201802852

DO - 10.1002/adfm.201802852

M3 - Review Article

VL - 29

SP - 1802852

JO - Advanced Functional Materials

T2 - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 2

ER -