Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil

T. Seppanen-Laakso, Into Laakso, T. Lehtimäki, R. Rontu, E. Moilanen, T. Solakivi, L. Seppo, H. Vanhanen, K. Kiviranta, R. Hiltunen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.

Original languageEnglish
JournalProstaglandins, Leukotrienes & Essential Fatty Acids
Volume83
Issue number1
Pages (from-to)45-54
Number of pages10
ISSN0952-3278
DOIs
Publication statusPublished - Jul 2010
MoE publication typeA1 Journal article-refereed

Bibliographical note

The press release (08.11.2010) has been noticed by a number of medical and nutrition news worldwide. Key words: canola-type rapeseed oil and fibrinogen http://notes.helsinki.fi/halvi/tiedotus/pressrelease.nsf/e1e392ad852e72f5c225680000404fa8/83c59ddf72eb9c3ac22577d50032562e?OpenDocument

Fields of Science

  • 317 Pharmacy
  • fatty acid analysis
  • fatty acid metabolism
  • fibrinogen
  • canola-type rapeseed oil

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