Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus

Enass Yousif Abdelkarium Salih, Pia Fyhrquist, Raimo Vilho Kari Hiltunen, Heikki Juhani Vuorela, Riitta Julkunen-Tiitto

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Abstract

Terminalia sambesiaca, Terminalia kaiserana and Terminalia brownii are native to East and South African Miombo and dry woodlands. Anogeissus leiocarpus is found both in West and East Africa. Roots, stem bark and leaves are prepared to hot water decoctions and teas or mixed in maize porridge for infectious diseases and their symptoms, diarrhea and cough [1]. Although ellagitannins and ellagic acid derivatives have been identified from several species of Terminalia, T. sambesiaca and T. kaiserana have not been studied before in this context. Ellagitannins [2] and ellagic acid derivatives [3] have been identified in A. leiocarpus and seven ellagic acid derivatives [4] are known from T. brownii, but since these species have given interesting antimicrobial profiles in our screenings they should be studied in detail for active compounds. Our data obtained using MS-QTOF indicate that methanol extracts of the roots of T. sambesiaca contain the ellagitannins corilagin, terchebulin and its isomer along with several unknown ellagitannins as well as ellagic acid glycosides. Root extracts of T. kaiserana contain punicalin, punicalagin and its isomer as well as terchebulin, castalagin and terflavin-A together with unknown ellagitannins and several ellagic acid derivatives. Ellagic acid derivatives and ellagitannins were identified from the roots of T. brownii and stem bark of A. leiocarpus. Ampelopsin was found for the first time in A. leiocarpus. All species possess promising antibacterial, antimycobacterial and antifungal activities. MIC as low as 39 – 78 µg/ml was recorded for some root and stem bark extracts of T. brownii and A. leiocarpus against P. aeruginosa and S. aureus.
Original languageEnglish
Title of host publication62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) : In Planta Medica
PublisherPlanta Medica
Publication date5 Jul 2014
ISBN (Electronic)In Planta Medica
DOIs
Publication statusPublished - 5 Jul 2014
MoE publication typeA4 Article in conference proceedings
Event62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) - Guimaraes, Portugal
Duration: 3 Jul 20147 Jul 2014
Conference number: 62

Cite this

Salih, E. Y. A., Fyhrquist, P., Hiltunen, R. V. K., Vuorela, H. J., & Julkunen-Tiitto, R. (2014). Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus. In 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA): In Planta Medica Planta Medica. https://doi.org/10.1055/s-0034-1394668
Salih, Enass Yousif Abdelkarium ; Fyhrquist, Pia ; Hiltunen, Raimo Vilho Kari ; Vuorela, Heikki Juhani ; Julkunen-Tiitto, Riitta. / Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus. 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA): In Planta Medica. Planta Medica, 2014.
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title = "Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus",
abstract = "Terminalia sambesiaca, Terminalia kaiserana and Terminalia brownii are native to East and South African Miombo and dry woodlands. Anogeissus leiocarpus is found both in West and East Africa. Roots, stem bark and leaves are prepared to hot water decoctions and teas or mixed in maize porridge for infectious diseases and their symptoms, diarrhea and cough [1]. Although ellagitannins and ellagic acid derivatives have been identified from several species of Terminalia, T. sambesiaca and T. kaiserana have not been studied before in this context. Ellagitannins [2] and ellagic acid derivatives [3] have been identified in A. leiocarpus and seven ellagic acid derivatives [4] are known from T. brownii, but since these species have given interesting antimicrobial profiles in our screenings they should be studied in detail for active compounds. Our data obtained using MS-QTOF indicate that methanol extracts of the roots of T. sambesiaca contain the ellagitannins corilagin, terchebulin and its isomer along with several unknown ellagitannins as well as ellagic acid glycosides. Root extracts of T. kaiserana contain punicalin, punicalagin and its isomer as well as terchebulin, castalagin and terflavin-A together with unknown ellagitannins and several ellagic acid derivatives. Ellagic acid derivatives and ellagitannins were identified from the roots of T. brownii and stem bark of A. leiocarpus. Ampelopsin was found for the first time in A. leiocarpus. All species possess promising antibacterial, antimycobacterial and antifungal activities. MIC as low as 39 – 78 µg/ml was recorded for some root and stem bark extracts of T. brownii and A. leiocarpus against P. aeruginosa and S. aureus.",
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Salih, EYA, Fyhrquist, P, Hiltunen, RVK, Vuorela, HJ & Julkunen-Tiitto, R 2014, Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus. in 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA): In Planta Medica. Planta Medica, 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Guimaraes, Portugal, 03/07/2014. https://doi.org/10.1055/s-0034-1394668

Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus. / Salih, Enass Yousif Abdelkarium; Fyhrquist, Pia; Hiltunen, Raimo Vilho Kari; Vuorela, Heikki Juhani; Julkunen-Tiitto, Riitta.

62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA): In Planta Medica. Planta Medica, 2014.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

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T1 - Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus

AU - Salih, Enass Yousif Abdelkarium

AU - Fyhrquist, Pia

AU - Hiltunen, Raimo Vilho Kari

AU - Vuorela, Heikki Juhani

AU - Julkunen-Tiitto, Riitta

N1 - Volume: Proceeding volume:

PY - 2014/7/5

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N2 - Terminalia sambesiaca, Terminalia kaiserana and Terminalia brownii are native to East and South African Miombo and dry woodlands. Anogeissus leiocarpus is found both in West and East Africa. Roots, stem bark and leaves are prepared to hot water decoctions and teas or mixed in maize porridge for infectious diseases and their symptoms, diarrhea and cough [1]. Although ellagitannins and ellagic acid derivatives have been identified from several species of Terminalia, T. sambesiaca and T. kaiserana have not been studied before in this context. Ellagitannins [2] and ellagic acid derivatives [3] have been identified in A. leiocarpus and seven ellagic acid derivatives [4] are known from T. brownii, but since these species have given interesting antimicrobial profiles in our screenings they should be studied in detail for active compounds. Our data obtained using MS-QTOF indicate that methanol extracts of the roots of T. sambesiaca contain the ellagitannins corilagin, terchebulin and its isomer along with several unknown ellagitannins as well as ellagic acid glycosides. Root extracts of T. kaiserana contain punicalin, punicalagin and its isomer as well as terchebulin, castalagin and terflavin-A together with unknown ellagitannins and several ellagic acid derivatives. Ellagic acid derivatives and ellagitannins were identified from the roots of T. brownii and stem bark of A. leiocarpus. Ampelopsin was found for the first time in A. leiocarpus. All species possess promising antibacterial, antimycobacterial and antifungal activities. MIC as low as 39 – 78 µg/ml was recorded for some root and stem bark extracts of T. brownii and A. leiocarpus against P. aeruginosa and S. aureus.

AB - Terminalia sambesiaca, Terminalia kaiserana and Terminalia brownii are native to East and South African Miombo and dry woodlands. Anogeissus leiocarpus is found both in West and East Africa. Roots, stem bark and leaves are prepared to hot water decoctions and teas or mixed in maize porridge for infectious diseases and their symptoms, diarrhea and cough [1]. Although ellagitannins and ellagic acid derivatives have been identified from several species of Terminalia, T. sambesiaca and T. kaiserana have not been studied before in this context. Ellagitannins [2] and ellagic acid derivatives [3] have been identified in A. leiocarpus and seven ellagic acid derivatives [4] are known from T. brownii, but since these species have given interesting antimicrobial profiles in our screenings they should be studied in detail for active compounds. Our data obtained using MS-QTOF indicate that methanol extracts of the roots of T. sambesiaca contain the ellagitannins corilagin, terchebulin and its isomer along with several unknown ellagitannins as well as ellagic acid glycosides. Root extracts of T. kaiserana contain punicalin, punicalagin and its isomer as well as terchebulin, castalagin and terflavin-A together with unknown ellagitannins and several ellagic acid derivatives. Ellagic acid derivatives and ellagitannins were identified from the roots of T. brownii and stem bark of A. leiocarpus. Ampelopsin was found for the first time in A. leiocarpus. All species possess promising antibacterial, antimycobacterial and antifungal activities. MIC as low as 39 – 78 µg/ml was recorded for some root and stem bark extracts of T. brownii and A. leiocarpus against P. aeruginosa and S. aureus.

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Salih EYA, Fyhrquist P, Hiltunen RVK, Vuorela HJ, Julkunen-Tiitto R. Ellagitannins, ellagic acid derivatives and ampelopsin in antimicrobial root and stem bark extracts of some selected African species of Terminalia and Anogeissus leiocarpus. In 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA): In Planta Medica. Planta Medica. 2014 https://doi.org/10.1055/s-0034-1394668