Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Abstract

Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].
We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.
A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.
Original languageEnglish
Title of host publicationUnknown host publication
Number of pages1
Place of PublicationBudapest
PublisherPlanta Medica
Publication date2015
Pages1-1
DOIs
Publication statusPublished - 2015
MoE publication typeA4 Article in conference proceedings
Event63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) - Budapest, Hungary
Duration: 23 Aug 201527 Aug 2015
Conference number: 63

Cite this

@inproceedings{2271bbe20f7841c79c0a622417c9df38,
title = "Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans",
abstract = "Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.",
author = "Salih, {Enass Yousif Abdelkarium} and Pia Fyhrquist and Laakso, {Into Johannes} and Vuorela, {Heikki Juhani} and Riitta Julkunen-Tiitto",
note = "Volume: Proceeding volume:",
year = "2015",
doi = "10.1055/s-0035-1565627",
language = "English",
pages = "1--1",
booktitle = "Unknown host publication",
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Salih, EYA, Fyhrquist, P, Laakso, IJ, Vuorela, HJ & Julkunen-Tiitto, R 2015, Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans. in Unknown host publication. Planta Medica, Budapest, pp. 1-1, 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Budapest, Hungary, 23/08/2015. https://doi.org/10.1055/s-0035-1565627

Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans. / Salih, Enass Yousif Abdelkarium; Fyhrquist, Pia; Laakso, Into Johannes; Vuorela, Heikki Juhani; Julkunen-Tiitto, Riitta.

Unknown host publication. Budapest : Planta Medica, 2015. p. 1-1.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

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T1 - Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans

AU - Salih, Enass Yousif Abdelkarium

AU - Fyhrquist, Pia

AU - Laakso, Into Johannes

AU - Vuorela, Heikki Juhani

AU - Julkunen-Tiitto, Riitta

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PY - 2015

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N2 - Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.

AB - Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.

U2 - 10.1055/s-0035-1565627

DO - 10.1055/s-0035-1565627

M3 - Conference contribution

SP - 1

EP - 1

BT - Unknown host publication

PB - Planta Medica

CY - Budapest

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