Emerging picture of host chaperone and cyclophilin roles in RNA virus replication.

Peter Nagy, R.Y. Wang, Judith Pogany, Anders Johannes Hafren, Kristiina Mäkinen

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.

Original languageEnglish
JournalVirology
Volume411
Issue number2
Pages (from-to)374-382
Number of pages9
ISSN0042-6822
DOIs
Publication statusPublished - 2011
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 1183 Plant biology, microbiology, virology

Cite this

Nagy, Peter ; Wang, R.Y. ; Pogany, Judith ; Hafren, Anders Johannes ; Mäkinen, Kristiina. / Emerging picture of host chaperone and cyclophilin roles in RNA virus replication. In: Virology. 2011 ; Vol. 411, No. 2. pp. 374-382.
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abstract = "Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.",
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Emerging picture of host chaperone and cyclophilin roles in RNA virus replication. / Nagy, Peter; Wang, R.Y.; Pogany, Judith; Hafren, Anders Johannes; Mäkinen, Kristiina.

In: Virology, Vol. 411, No. 2, 2011, p. 374-382.

Research output: Contribution to journalReview ArticleScientificpeer-review

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T1 - Emerging picture of host chaperone and cyclophilin roles in RNA virus replication.

AU - Nagy, Peter

AU - Wang, R.Y.

AU - Pogany, Judith

AU - Hafren, Anders Johannes

AU - Mäkinen, Kristiina

PY - 2011

Y1 - 2011

N2 - Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.

AB - Many plus-strand (+)RNA viruses co-opt protein chaperones from the host cell to assist the synthesis, localization and folding of abundant viral proteins, to regulate viral replication via activation of replication proteins and to interfere with host antiviral responses. The most frequently subverted host chaperones are heat shock protein 70 (Hsp70), Hsp90 and the J-domain co-chaperones. The various roles of these host chaperones in RNA virus replication are presented to illustrate the astonishing repertoire of host chaperone functions that are subverted by RNA viruses. This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses.

KW - 1183 Plant biology, microbiology, virology

U2 - 10.1016/j.virol.2010.12.061

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