Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children

Marja Roslund, Sonja Rantala, Sami Oikarinen, Riikka Puhakka, Nan Hui, Anirudra Parajuli, Olli-Heikki Laitinen, Heikki Hyöty, Anna-Lea Rantalainen, Aki Sinkkonen, The ADELE Research Group

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways.

To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments.

We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health.

Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.

Original languageEnglish
Article number104894
JournalEnvironment International
Volume130
Number of pages8
ISSN0160-4120
DOIs
Publication statusPublished - Sep 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • HEALTH
  • IMPACT
  • INDICATORS
  • INFLAMMATION
  • MICROBIOTA
  • MYCOBACTERIA
  • POLYCYCLIC AROMATIC-HYDROCARBONS
  • PPAR-GAMMA
  • SENSITIVITY
  • SEQUENCE DATA
  • 3142 Public health care science, environmental and occupational health

Projects

ADELE: Autoimmune Defense and Living Environment

Sinkkonen, A., Puhakka, R., Grönroos, M., Romantschuk, M., Strömmer, R., Valve, R., Parajuli, A., Hyöty, H., Laitinen, O., Rajaniemi, J., Siter, N., Roslund, M., Vari, H., Oikarinen, S. & Nurminen, N.

Unknown funder

01/01/201531/12/2019

Project: Research project

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