Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Yueqi Zhu, Hongbo Zhang, Yiran Zhang, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng, Minghua Li, Helder Almeida Santos, Wenguo Cui

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in‐depth understanding of the mechanical and material performance of these metal‐based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.
Original languageEnglish
Article number1805452
JournalAdvanced Materials
Volume31
Issue number8
Number of pages44
ISSN0935-9648
DOIs
Publication statusPublished - 22 Feb 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • ACUTE ISCHEMIC-STROKE
  • BARE PLATINUM COILS
  • INTERNAL CAROTID-ARTERY
  • MUSCLE-CELL-PROLIFERATION
  • PIPELINE EMBOLIZATION DEVICE
  • SINGLE-CENTER EXPERIENCE
  • SIROLIMUS-ELUTING STENT
  • STENT-ASSISTED COILING
  • UNRUPTURED INTRACRANIAL ANEURYSMS
  • WILLIS COVERED STENT
  • biodegradable
  • cerebrovascular disease
  • drug elution
  • flexible endovascular devices
  • metal-based stents
  • 116 Chemical sciences
  • 317 Pharmacy
  • 221 Nano-technology
  • 216 Materials engineering

Cite this

Zhu, Y., Zhang, H., Zhang, Y., Wu, H., Wei, L., Zhou, G., ... Cui, W. (2019). Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Advanced Materials, 31(8), [1805452]. https://doi.org/10.1002/adma.201805452
Zhu, Yueqi ; Zhang, Hongbo ; Zhang, Yiran ; Wu, Huayin ; Wei, Liming ; Zhou, Gen ; Zhang, Yuezhou ; Deng, Lianfu ; Cheng, Yingsheng ; Li, Minghua ; Almeida Santos, Helder ; Cui, Wenguo. / Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. In: Advanced Materials. 2019 ; Vol. 31, No. 8.
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abstract = "Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in‐depth understanding of the mechanical and material performance of these metal‐based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.",
keywords = "ACUTE ISCHEMIC-STROKE, BARE PLATINUM COILS, INTERNAL CAROTID-ARTERY, MUSCLE-CELL-PROLIFERATION, PIPELINE EMBOLIZATION DEVICE, SINGLE-CENTER EXPERIENCE, SIROLIMUS-ELUTING STENT, STENT-ASSISTED COILING, UNRUPTURED INTRACRANIAL ANEURYSMS, WILLIS COVERED STENT, biodegradable, cerebrovascular disease, drug elution, flexible endovascular devices, metal-based stents, 116 Chemical sciences, 317 Pharmacy, 221 Nano-technology, 216 Materials engineering",
author = "Yueqi Zhu and Hongbo Zhang and Yiran Zhang and Huayin Wu and Liming Wei and Gen Zhou and Yuezhou Zhang and Lianfu Deng and Yingsheng Cheng and Minghua Li and {Almeida Santos}, Helder and Wenguo Cui",
year = "2019",
month = "2",
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volume = "31",
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Zhu, Y, Zhang, H, Zhang, Y, Wu, H, Wei, L, Zhou, G, Zhang, Y, Deng, L, Cheng, Y, Li, M, Almeida Santos, H & Cui, W 2019, 'Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases' Advanced Materials, vol. 31, no. 8, 1805452. https://doi.org/10.1002/adma.201805452

Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. / Zhu, Yueqi; Zhang, Hongbo; Zhang, Yiran; Wu, Huayin; Wei, Liming; Zhou, Gen; Zhang, Yuezhou; Deng, Lianfu; Cheng, Yingsheng; Li, Minghua; Almeida Santos, Helder; Cui, Wenguo.

In: Advanced Materials, Vol. 31, No. 8, 1805452, 22.02.2019.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

AU - Zhu, Yueqi

AU - Zhang, Hongbo

AU - Zhang, Yiran

AU - Wu, Huayin

AU - Wei, Liming

AU - Zhou, Gen

AU - Zhang, Yuezhou

AU - Deng, Lianfu

AU - Cheng, Yingsheng

AU - Li, Minghua

AU - Almeida Santos, Helder

AU - Cui, Wenguo

PY - 2019/2/22

Y1 - 2019/2/22

N2 - Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in‐depth understanding of the mechanical and material performance of these metal‐based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.

AB - Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in‐depth understanding of the mechanical and material performance of these metal‐based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.

KW - ACUTE ISCHEMIC-STROKE

KW - BARE PLATINUM COILS

KW - INTERNAL CAROTID-ARTERY

KW - MUSCLE-CELL-PROLIFERATION

KW - PIPELINE EMBOLIZATION DEVICE

KW - SINGLE-CENTER EXPERIENCE

KW - SIROLIMUS-ELUTING STENT

KW - STENT-ASSISTED COILING

KW - UNRUPTURED INTRACRANIAL ANEURYSMS

KW - WILLIS COVERED STENT

KW - biodegradable

KW - cerebrovascular disease

KW - drug elution

KW - flexible endovascular devices

KW - metal-based stents

KW - 116 Chemical sciences

KW - 317 Pharmacy

KW - 221 Nano-technology

KW - 216 Materials engineering

U2 - 10.1002/adma.201805452

DO - 10.1002/adma.201805452

M3 - Review Article

VL - 31

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 8

M1 - 1805452

ER -