Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Yueqi Zhu, Hongbo Zhang, Yiran Zhang, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng, Minghua Li, Helder Almeida Santos, Wenguo Cui

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in‐depth understanding of the mechanical and material performance of these metal‐based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.
Original languageEnglish
Article number1805452
JournalAdvanced Materials
Volume31
Issue number8
Number of pages44
ISSN0935-9648
DOIs
Publication statusPublished - 22 Feb 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • ACUTE ISCHEMIC-STROKE
  • BARE PLATINUM COILS
  • INTERNAL CAROTID-ARTERY
  • MUSCLE-CELL-PROLIFERATION
  • PIPELINE EMBOLIZATION DEVICE
  • SINGLE-CENTER EXPERIENCE
  • SIROLIMUS-ELUTING STENT
  • STENT-ASSISTED COILING
  • UNRUPTURED INTRACRANIAL ANEURYSMS
  • WILLIS COVERED STENT
  • biodegradable
  • cerebrovascular disease
  • drug elution
  • flexible endovascular devices
  • metal-based stents
  • 116 Chemical sciences
  • 317 Pharmacy
  • 221 Nano-technology
  • 216 Materials engineering

Cite this

Zhu, Y., Zhang, H., Zhang, Y., Wu, H., Wei, L., Zhou, G., ... Cui, W. (2019). Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Advanced Materials, 31(8), [1805452]. https://doi.org/10.1002/adma.201805452