Energy-Dependent Intranuclear Movements: Role of Nuclear Actin and Myosins

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

The actin cytoskeleton is the major driving force for motility of the cell and its constituents. The mechanisms of actin-based motility in the cytoplasm are well characterized, and actin produces the force harnessed for movement either through polymerization of actin monomers to polar filaments or together with motor proteins myosins. Actin, as well as several myosins, are also present in the cell nucleus, and have been linked to gene expression processes. Nuclear actin therefore harbours both the required connections and biochemical properties to power motility events also in this cellular compartment. Indeed, recent functional data have demonstrated a role for actin and myosin in energy-dependent movements of chromosomes and chromosomal loci. In this chapter, we discuss the current knowledge on the organization of nuclear actin, its connection to nuclear gene expression machineries and the present evidence for actin-based motility in the nucleus, which has the potential to play a critical role in the functional organization of the nucleus itself.
Original languageEnglish
Title of host publicationThe Functional Nucleus
EditorsDavid P. Bazett-Jones, Graham Dellaire
Number of pages14
PublisherSpringer
Publication date18 Oct 2016
Pages1-513
ISBN (Print)978-3-319-38880-9
ISBN (Electronic)978-3-319-38882-3
DOIs
Publication statusPublished - 18 Oct 2016
MoE publication typeA3 Book chapter

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

Cite this

Huet, G., & Vartiainen, M. K. (2016). Energy-Dependent Intranuclear Movements: Role of Nuclear Actin and Myosins. In D. P. Bazett-Jones, & G. Dellaire (Eds.), The Functional Nucleus (pp. 1-513). Springer. https://doi.org/10.1007/978-3-319-38882-3_14
Huet, Guillaume ; Vartiainen, Maria Kristina. / Energy-Dependent Intranuclear Movements : Role of Nuclear Actin and Myosins. The Functional Nucleus. editor / David P. Bazett-Jones ; Graham Dellaire. Springer, 2016. pp. 1-513
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Huet, G & Vartiainen, MK 2016, Energy-Dependent Intranuclear Movements: Role of Nuclear Actin and Myosins. in DP Bazett-Jones & G Dellaire (eds), The Functional Nucleus. Springer, pp. 1-513. https://doi.org/10.1007/978-3-319-38882-3_14

Energy-Dependent Intranuclear Movements : Role of Nuclear Actin and Myosins. / Huet, Guillaume; Vartiainen, Maria Kristina.

The Functional Nucleus. ed. / David P. Bazett-Jones; Graham Dellaire. Springer, 2016. p. 1-513.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

TY - CHAP

T1 - Energy-Dependent Intranuclear Movements

T2 - Role of Nuclear Actin and Myosins

AU - Huet, Guillaume

AU - Vartiainen, Maria Kristina

PY - 2016/10/18

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N2 - The actin cytoskeleton is the major driving force for motility of the cell and its constituents. The mechanisms of actin-based motility in the cytoplasm are well characterized, and actin produces the force harnessed for movement either through polymerization of actin monomers to polar filaments or together with motor proteins myosins. Actin, as well as several myosins, are also present in the cell nucleus, and have been linked to gene expression processes. Nuclear actin therefore harbours both the required connections and biochemical properties to power motility events also in this cellular compartment. Indeed, recent functional data have demonstrated a role for actin and myosin in energy-dependent movements of chromosomes and chromosomal loci. In this chapter, we discuss the current knowledge on the organization of nuclear actin, its connection to nuclear gene expression machineries and the present evidence for actin-based motility in the nucleus, which has the potential to play a critical role in the functional organization of the nucleus itself.

AB - The actin cytoskeleton is the major driving force for motility of the cell and its constituents. The mechanisms of actin-based motility in the cytoplasm are well characterized, and actin produces the force harnessed for movement either through polymerization of actin monomers to polar filaments or together with motor proteins myosins. Actin, as well as several myosins, are also present in the cell nucleus, and have been linked to gene expression processes. Nuclear actin therefore harbours both the required connections and biochemical properties to power motility events also in this cellular compartment. Indeed, recent functional data have demonstrated a role for actin and myosin in energy-dependent movements of chromosomes and chromosomal loci. In this chapter, we discuss the current knowledge on the organization of nuclear actin, its connection to nuclear gene expression machineries and the present evidence for actin-based motility in the nucleus, which has the potential to play a critical role in the functional organization of the nucleus itself.

KW - 1182 Biochemistry, cell and molecular biology

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Huet G, Vartiainen MK. Energy-Dependent Intranuclear Movements: Role of Nuclear Actin and Myosins. In Bazett-Jones DP, Dellaire G, editors, The Functional Nucleus. Springer. 2016. p. 1-513 https://doi.org/10.1007/978-3-319-38882-3_14