Abstract
Whole-Slide Images (WSI) are emerging as a promising resource for studying biological tissues, demonstrating a great potential in aiding cancer diagnosis and improving patient treatment. However, the manual pixel-level annotation of WSIs is extremely time-consuming and practically unfeasible in real-world scenarios. Multi-Instance Learning (MIL) have gained attention as a weakly supervised approach able to address lack of annotation tasks. MIL models aggregate patches (e.g., cropping of a WSI) into bag-level representations (e.g., WSI label), but neglect spatial information of the WSIs, crucial for histological analysis. In the High-Grade Serous Ovarian Cancer (HGSOC) context, spatial information is essential to predict a prognosis indicator (the Platinum-Free Interval, PFI) from WSIs. Such a prediction would bring highly valuable insights both for patient treatment and prognosis of chemotherapy resistance. Indeed, NeoAdjuvant ChemoTherapy (NACT) induces changes in tumor tissue morphology and composition, making the prediction of PFI from WSIs extremely challenging. In this paper, we propose GDS-MIL, a method that integrates a state-of-the-art MIL model with a Graph ATtention layer (GAT in short) to inject a local context into each instance before MIL aggregation. Our approach achieves a significant improvement in accuracy on the “Ome18” PFI dataset. In summary, this paper presents a novel solution for enhancing PFI prediction in HGSOC, with the potential of significantly improving treatment decisions and patient outcomes.
Original language | English |
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Title of host publication | Image Analysis and Processing – ICIAP 2023 - 22nd International Conference, ICIAP 2023, Proceedings |
Editors | Gian Luca Foresti, Andrea Fusiello, Edwin Hancock |
Number of pages | 13 |
Publisher | Springer Science and Business Media Deutschland GmbH |
Publication date | 2023 |
Pages | 550-562 |
ISBN (Print) | 978-3-031-43147-0 |
DOIs | |
Publication status | Published - 2023 |
MoE publication type | A4 Article in conference proceedings |
Event | International Conference on Image Analysis and Processing - Udine, Italy Duration: 11 Sept 2023 → 15 Sept 2023 Conference number: 22 |
Publication series
Name | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
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Volume | 14233 LNCS |
ISSN (Print) | 0302-9743 |
ISSN (Electronic) | 1611-3349 |
Fields of Science
- 113 Computer and information sciences