Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk

Anthony S. Zannas, Meiwen Jia, Kathrin Hafner, Jens Baumert, Tobias Wiechmann, Julius C. Pape, Janine Arloth, Maik Ködel, Silvia Martinelli, Maria Roitman, Simone Roeh, Andreas Haehle, Rebecca T. Emeny, Stella Iurato, Tania Carrillo-Roa, Jari Lahti, Katri Räikkönen, Johan G. Eriksson, Amanda J. Drake, Melanie WaldenbergerSimone Wahl, Sonja Kunze, Susanne Lucae, Bekh Bradley, Christian Gieger, Felix Hausch, Alicia K. Smith, Kerry J. Ressler, Bertram Mueller-Myhsok, Karl-Heinz Ladwig, Theo Rein, Nils C. Gassen, Elisabeth B. Binder

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number23
Pages (from-to)11370-11379
Number of pages10
ISSN0027-8424
DOIs
Publication statusPublished - 4 Jun 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • aging
  • epigenetics
  • FKBP5
  • inflammation
  • psychosocial stress
  • ADVERSE CHILDHOOD EXPERIENCES
  • ALL-CAUSE MORTALITY
  • C-REACTIVE PROTEIN
  • DNA METHYLATION
  • DEPRESSIVE SYMPTOMS
  • LYMPHOCYTE RATIO
  • HEALTHY-MEN
  • DISEASE
  • HEART
  • IL-8
  • 515 Psychology
  • 3121 Internal medicine

Cite this

Zannas, Anthony S. ; Jia, Meiwen ; Hafner, Kathrin ; Baumert, Jens ; Wiechmann, Tobias ; Pape, Julius C. ; Arloth, Janine ; Ködel, Maik ; Martinelli, Silvia ; Roitman, Maria ; Roeh, Simone ; Haehle, Andreas ; Emeny, Rebecca T. ; Iurato, Stella ; Carrillo-Roa, Tania ; Lahti, Jari ; Räikkönen, Katri ; Eriksson, Johan G. ; Drake, Amanda J. ; Waldenberger, Melanie ; Wahl, Simone ; Kunze, Sonja ; Lucae, Susanne ; Bradley, Bekh ; Gieger, Christian ; Hausch, Felix ; Smith, Alicia K. ; Ressler, Kerry J. ; Mueller-Myhsok, Bertram ; Ladwig, Karl-Heinz ; Rein, Theo ; Gassen, Nils C. ; Binder, Elisabeth B. / Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 23. pp. 11370-11379.
@article{c0b2619e77174c94abc26dcaa4e18635,
title = "Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk",
keywords = "aging, epigenetics, FKBP5, inflammation, psychosocial stress, ADVERSE CHILDHOOD EXPERIENCES, ALL-CAUSE MORTALITY, C-REACTIVE PROTEIN, DNA METHYLATION, DEPRESSIVE SYMPTOMS, LYMPHOCYTE RATIO, HEALTHY-MEN, DISEASE, HEART, IL-8, 515 Psychology, 3121 Internal medicine",
author = "Zannas, {Anthony S.} and Meiwen Jia and Kathrin Hafner and Jens Baumert and Tobias Wiechmann and Pape, {Julius C.} and Janine Arloth and Maik K{\"o}del and Silvia Martinelli and Maria Roitman and Simone Roeh and Andreas Haehle and Emeny, {Rebecca T.} and Stella Iurato and Tania Carrillo-Roa and Jari Lahti and Katri R{\"a}ikk{\"o}nen and Eriksson, {Johan G.} and Drake, {Amanda J.} and Melanie Waldenberger and Simone Wahl and Sonja Kunze and Susanne Lucae and Bekh Bradley and Christian Gieger and Felix Hausch and Smith, {Alicia K.} and Ressler, {Kerry J.} and Bertram Mueller-Myhsok and Karl-Heinz Ladwig and Theo Rein and Gassen, {Nils C.} and Binder, {Elisabeth B.}",
year = "2019",
month = "6",
day = "4",
doi = "10.1073/pnas.1816847116",
language = "English",
volume = "116",
pages = "11370--11379",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "23",

}

Zannas, AS, Jia, M, Hafner, K, Baumert, J, Wiechmann, T, Pape, JC, Arloth, J, Ködel, M, Martinelli, S, Roitman, M, Roeh, S, Haehle, A, Emeny, RT, Iurato, S, Carrillo-Roa, T, Lahti, J, Räikkönen, K, Eriksson, JG, Drake, AJ, Waldenberger, M, Wahl, S, Kunze, S, Lucae, S, Bradley, B, Gieger, C, Hausch, F, Smith, AK, Ressler, KJ, Mueller-Myhsok, B, Ladwig, K-H, Rein, T, Gassen, NC & Binder, EB 2019, 'Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 23, pp. 11370-11379. https://doi.org/10.1073/pnas.1816847116

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk. / Zannas, Anthony S.; Jia, Meiwen; Hafner, Kathrin; Baumert, Jens; Wiechmann, Tobias; Pape, Julius C.; Arloth, Janine; Ködel, Maik; Martinelli, Silvia; Roitman, Maria; Roeh, Simone; Haehle, Andreas; Emeny, Rebecca T.; Iurato, Stella; Carrillo-Roa, Tania; Lahti, Jari; Räikkönen, Katri; Eriksson, Johan G.; Drake, Amanda J.; Waldenberger, Melanie; Wahl, Simone; Kunze, Sonja; Lucae, Susanne; Bradley, Bekh; Gieger, Christian; Hausch, Felix; Smith, Alicia K.; Ressler, Kerry J.; Mueller-Myhsok, Bertram; Ladwig, Karl-Heinz; Rein, Theo; Gassen, Nils C.; Binder, Elisabeth B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 23, 04.06.2019, p. 11370-11379.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk

AU - Zannas, Anthony S.

AU - Jia, Meiwen

AU - Hafner, Kathrin

AU - Baumert, Jens

AU - Wiechmann, Tobias

AU - Pape, Julius C.

AU - Arloth, Janine

AU - Ködel, Maik

AU - Martinelli, Silvia

AU - Roitman, Maria

AU - Roeh, Simone

AU - Haehle, Andreas

AU - Emeny, Rebecca T.

AU - Iurato, Stella

AU - Carrillo-Roa, Tania

AU - Lahti, Jari

AU - Räikkönen, Katri

AU - Eriksson, Johan G.

AU - Drake, Amanda J.

AU - Waldenberger, Melanie

AU - Wahl, Simone

AU - Kunze, Sonja

AU - Lucae, Susanne

AU - Bradley, Bekh

AU - Gieger, Christian

AU - Hausch, Felix

AU - Smith, Alicia K.

AU - Ressler, Kerry J.

AU - Mueller-Myhsok, Bertram

AU - Ladwig, Karl-Heinz

AU - Rein, Theo

AU - Gassen, Nils C.

AU - Binder, Elisabeth B.

PY - 2019/6/4

Y1 - 2019/6/4

KW - aging

KW - epigenetics

KW - FKBP5

KW - inflammation

KW - psychosocial stress

KW - ADVERSE CHILDHOOD EXPERIENCES

KW - ALL-CAUSE MORTALITY

KW - C-REACTIVE PROTEIN

KW - DNA METHYLATION

KW - DEPRESSIVE SYMPTOMS

KW - LYMPHOCYTE RATIO

KW - HEALTHY-MEN

KW - DISEASE

KW - HEART

KW - IL-8

KW - 515 Psychology

KW - 3121 Internal medicine

U2 - 10.1073/pnas.1816847116

DO - 10.1073/pnas.1816847116

M3 - Article

VL - 116

SP - 11370

EP - 11379

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 23

ER -