Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis

Yufei Yan, Tao Sun, Hongbo Zhang, Xiuling Ji, Yulong Sun, Xin Zhao, Lianfu Deng, Jin Qi, Wenguo Cui, Helder Almeida Santos, Hongyu Zhang

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3‐sulfopropyl methacrylate potassium salt)‐grafted mesoporous silica nanoparticles (MSNs‐NH2@PSPMK), is biomimicked and synthesized via a one‐step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti‐inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS‐loaded MSNs‐NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis.
Original languageEnglish
Article number1807559
JournalAdvanced Functional Materials
Volume29
Issue number4
Number of pages14
ISSN1616-301X
DOIs
Publication statusPublished - 24 Jan 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • DELIVERY
  • LUBRICATION
  • MESOPOROUS SILICA NANOPARTICLES
  • NANOCARRIERS
  • POLYELECTROLYTE BRUSHES
  • POLYMER BRUSHES
  • bioinspired
  • lubrication
  • nanoparticles
  • osteoarthritis
  • photopolymerization
  • 116 Chemical sciences
  • 221 Nano-technology
  • 216 Materials engineering
  • 114 Physical sciences
  • 317 Pharmacy

Cite this

Yan, Yufei ; Sun, Tao ; Zhang, Hongbo ; Ji, Xiuling ; Sun, Yulong ; Zhao, Xin ; Deng, Lianfu ; Qi, Jin ; Cui, Wenguo ; Almeida Santos, Helder ; Zhang, Hongyu. / Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis. In: Advanced Functional Materials. 2019 ; Vol. 29, No. 4.
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title = "Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis",
abstract = "Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3‐sulfopropyl methacrylate potassium salt)‐grafted mesoporous silica nanoparticles (MSNs‐NH2@PSPMK), is biomimicked and synthesized via a one‐step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti‐inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS‐loaded MSNs‐NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis.",
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author = "Yufei Yan and Tao Sun and Hongbo Zhang and Xiuling Ji and Yulong Sun and Xin Zhao and Lianfu Deng and Jin Qi and Wenguo Cui and {Almeida Santos}, Helder and Hongyu Zhang",
year = "2019",
month = "1",
day = "24",
doi = "10.1002/adfm.201807559",
language = "English",
volume = "29",
journal = "Advanced Functional Materials",
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Yan, Y, Sun, T, Zhang, H, Ji, X, Sun, Y, Zhao, X, Deng, L, Qi, J, Cui, W, Almeida Santos, H & Zhang, H 2019, 'Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis' Advanced Functional Materials, vol. 29, no. 4, 1807559. https://doi.org/10.1002/adfm.201807559

Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis. / Yan, Yufei; Sun, Tao; Zhang, Hongbo; Ji, Xiuling; Sun, Yulong; Zhao, Xin; Deng, Lianfu; Qi, Jin; Cui, Wenguo; Almeida Santos, Helder; Zhang, Hongyu.

In: Advanced Functional Materials, Vol. 29, No. 4, 1807559, 24.01.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis

AU - Yan, Yufei

AU - Sun, Tao

AU - Zhang, Hongbo

AU - Ji, Xiuling

AU - Sun, Yulong

AU - Zhao, Xin

AU - Deng, Lianfu

AU - Qi, Jin

AU - Cui, Wenguo

AU - Almeida Santos, Helder

AU - Zhang, Hongyu

PY - 2019/1/24

Y1 - 2019/1/24

N2 - Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3‐sulfopropyl methacrylate potassium salt)‐grafted mesoporous silica nanoparticles (MSNs‐NH2@PSPMK), is biomimicked and synthesized via a one‐step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti‐inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS‐loaded MSNs‐NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis.

AB - Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3‐sulfopropyl methacrylate potassium salt)‐grafted mesoporous silica nanoparticles (MSNs‐NH2@PSPMK), is biomimicked and synthesized via a one‐step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti‐inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS‐loaded MSNs‐NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis.

KW - DELIVERY

KW - LUBRICATION

KW - MESOPOROUS SILICA NANOPARTICLES

KW - NANOCARRIERS

KW - POLYELECTROLYTE BRUSHES

KW - POLYMER BRUSHES

KW - bioinspired

KW - lubrication

KW - nanoparticles

KW - osteoarthritis

KW - photopolymerization

KW - 116 Chemical sciences

KW - 221 Nano-technology

KW - 216 Materials engineering

KW - 114 Physical sciences

KW - 317 Pharmacy

UR - https://onlinelibrary.wiley.com/journal/16163028

U2 - 10.1002/adfm.201807559

DO - 10.1002/adfm.201807559

M3 - Article

VL - 29

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 4

M1 - 1807559

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