Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Broad Genomics Platform; DiscovEHR Collaboration; CHARGE; LuCamp; ProDiGY; GoT2D; ESP; SIGMA-T2D; T2D-GENES; AMP-T2D-GENES; Jason Flannick; Josep M. Mercader; Heikki A. Koistinen; Johanna Kuusisto; Leif Groop; Tiinamaija Tuomi; Jaakko Tuomilehto; Michael Boehnke

doi:10.1038/s41586-019-1231-2

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, Jason Flannick, Josep M. Mercader, Heikki A. Koistinen, Johanna Kuusisto, Leif Groop, Tiinamaija Tuomi, Jaakko Tuomilehto, Michael Boehnke

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature
Volume	570
Issue number	7759
Pages (from-to)	71-+
Number of pages	24
ISSN	0028-0836
DOIs	https://doi.org/10.1038/s41586-019-1231-2
Publication status	Published - 6 Jun 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

GENOME-WIDE ASSOCIATION
COMMON GENETIC-VARIATION
LOW-FREQUENCY
RARE VARIANTS
MUTATIONS
RISK
IDENTIFICATION
HERITABILITY
ARCHITECTURE
METAANALYSIS
3121 Internal medicine

Access to Document

10.1038/s41586-019-1231-2

s41586-019-1231-2Final published version, 8.57 MBLicence: CC BY

Cite this

Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, Flannick, J., Mercader, J. M., Koistinen, H. A., Kuusisto, J., Groop, L., Tuomi, T., Tuomilehto, J., & Boehnke, M. (2019). Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature, 570(7759), 71-+. https://doi.org/10.1038/s41586-019-1231-2

Broad Genomics Platform ; DiscovEHR Collaboration ; CHARGE ; LuCamp ; ProDiGY ; GoT2D ; ESP ; SIGMA-T2D ; T2D-GENES ; AMP-T2D-GENES ; Flannick, Jason ; Mercader, Josep M. ; Koistinen, Heikki A. ; Kuusisto, Johanna ; Groop, Leif ; Tuomi, Tiinamaija ; Tuomilehto, Jaakko ; Boehnke, Michael. / Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. In: Nature. 2019 ; Vol. 570, No. 7759. pp. 71-+.

@article{d04b4929c4674f01b8768ea60471b5a8,

title = "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls",

keywords = "GENOME-WIDE ASSOCIATION, COMMON GENETIC-VARIATION, LOW-FREQUENCY, RARE VARIANTS, MUTATIONS, RISK, IDENTIFICATION, HERITABILITY, ARCHITECTURE, METAANALYSIS, 3121 Internal medicine",

author = "{Broad Genomics Platform} and {DiscovEHR Collaboration} and CHARGE and LuCamp and ProDiGY and GoT2D and ESP and SIGMA-T2D and T2D-GENES and AMP-T2D-GENES and Jason Flannick and Mercader, {Josep M.} and Christian Fuchsberger and Udler, {Miriam S.} and Anubha Mahajan and Jennifer Wessel and Teslovich, {Tanya M.} and Lizz Caulkins and Ryan Koesterer and Francisco Barajas-Olmos and Blackwell, {Thomas W.} and Eric Boerwinkle and Brody, {Jennifer A.} and Federico Centeno-Cruz and Ling Chen and Siying Chen and Cecilia Contreras-Cubas and Emilio Cordova and Adolfo Correa and Maria Cortes and DeFronzo, {Ralph A.} and Lawrence Dolan and Drews, {Kimberly L.} and Amanda Elliott and Floyd, {James S.} and Stacey Gabriel and Garay-Sevilla, {Maria Eugenia} and Humberto Garcia-Ortiz and Myron Gross and Sohee Han and Heard-Costa, {Nancy L.} and Jackson, {Anne U.} and Jorgensen, {Marit E.} and Kang, {Hyun Min} and Megan Kelsey and Bong-Jo Kim and Koistinen, {Heikki A.} and Johanna Kuusisto and Leader, {Joseph B.} and Allan Linneberg and Ching-Ti Liu and Jianjun Liu and Valeriya Lyssenko and Manning, {Alisa K.} and Anthony Marcketta and Malacara-Hernandez, {Juan Manuel} and Angelica Martinez-Hernandez and Leif Groop and Tiinamaija Tuomi and Jaakko Tuomilehto and Michael Boehnke",

year = "2019",

month = jun,

day = "6",

doi = "10.1038/s41586-019-1231-2",

language = "English",

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journal = "Nature",

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Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, Flannick, J, Mercader, JM, Koistinen, HA, Kuusisto, J, Groop, L , Tuomi, T , Tuomilehto, J & Boehnke, M 2019, 'Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls', Nature, vol. 570, no. 7759, pp. 71-+. https://doi.org/10.1038/s41586-019-1231-2

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. / Broad Genomics Platform; DiscovEHR Collaboration; CHARGE; LuCamp; ProDiGY; GoT2D; ESP; SIGMA-T2D; T2D-GENES; AMP-T2D-GENES; Flannick, Jason; Mercader, Josep M.; Koistinen, Heikki A.; Kuusisto, Johanna; Groop, Leif ; Tuomi, Tiinamaija ; Tuomilehto, Jaakko; Boehnke, Michael.

In: Nature, Vol. 570, No. 7759, 06.06.2019, p. 71-+.

Research output: Contribution to journal › Article › Scientific › peer-review

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T1 - Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

AU - Broad Genomics Platform

AU - DiscovEHR Collaboration

AU - CHARGE

AU - LuCamp

AU - ProDiGY

AU - GoT2D

AU - ESP

AU - SIGMA-T2D

AU - T2D-GENES

AU - AMP-T2D-GENES

AU - Flannick, Jason

AU - Mercader, Josep M.

AU - Fuchsberger, Christian

AU - Udler, Miriam S.

AU - Mahajan, Anubha

AU - Wessel, Jennifer

AU - Teslovich, Tanya M.

AU - Caulkins, Lizz

AU - Koesterer, Ryan

AU - Barajas-Olmos, Francisco

AU - Blackwell, Thomas W.

AU - Boerwinkle, Eric

AU - Brody, Jennifer A.

AU - Centeno-Cruz, Federico

AU - Chen, Ling

AU - Chen, Siying

AU - Contreras-Cubas, Cecilia

AU - Cordova, Emilio

AU - Correa, Adolfo

AU - Cortes, Maria

AU - DeFronzo, Ralph A.

AU - Dolan, Lawrence

AU - Drews, Kimberly L.

AU - Elliott, Amanda

AU - Floyd, James S.

AU - Gabriel, Stacey

AU - Garay-Sevilla, Maria Eugenia

AU - Garcia-Ortiz, Humberto

AU - Gross, Myron

AU - Han, Sohee

AU - Heard-Costa, Nancy L.

AU - Jackson, Anne U.

AU - Jorgensen, Marit E.

AU - Kang, Hyun Min

AU - Kelsey, Megan

AU - Kim, Bong-Jo

AU - Koistinen, Heikki A.

AU - Kuusisto, Johanna

AU - Leader, Joseph B.

AU - Linneberg, Allan

AU - Liu, Ching-Ti

AU - Liu, Jianjun

AU - Lyssenko, Valeriya

AU - Manning, Alisa K.

AU - Marcketta, Anthony

AU - Malacara-Hernandez, Juan Manuel

AU - Martinez-Hernandez, Angelica

AU - Groop, Leif

AU - Tuomi, Tiinamaija

AU - Tuomilehto, Jaakko

AU - Boehnke, Michael

PY - 2019/6/6

Y1 - 2019/6/6

KW - GENOME-WIDE ASSOCIATION

KW - COMMON GENETIC-VARIATION

KW - LOW-FREQUENCY

KW - RARE VARIANTS

KW - MUTATIONS

KW - RISK

KW - IDENTIFICATION

KW - HERITABILITY

KW - ARCHITECTURE

KW - METAANALYSIS

KW - 3121 Internal medicine

U2 - 10.1038/s41586-019-1231-2

DO - 10.1038/s41586-019-1231-2

M3 - Article

VL - 570

SP - 71-+

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7759

ER -