Exome sequencing of Finnish isolates enhances rare-variant association power

FinnGen Project, Adam E. Locke, Aki S. Havulinna, Matti Pirinen, Johan G. Eriksson, Mika Ala-Korpela, Marjo-Riitta Järvelin, Minna Männikkö, Hannele Laivuori, Aarno Palotie, Veikko Salomaa, Markku Laakso, Samuli Ripatti

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature
Volume572
Issue number7769
Pages (from-to)323–+
Number of pages21
ISSN0028-0836
DOIs
Publication statusPublished - 15 Aug 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • LOW-FREQUENCY
  • MISSING HERITABILITY
  • CARDIOVASCULAR RISK
  • BLOOD-PRESSURE
  • DISEASE
  • TRAITS
  • CHOLESTEROL
  • POPULATION
  • PREDICTION
  • 3142 Public health care science, environmental and occupational health
  • 111 Mathematics

Cite this

FinnGen Project ; Locke, Adam E. ; Havulinna, Aki S. ; Pirinen, Matti ; Eriksson, Johan G. ; Ala-Korpela, Mika ; Järvelin, Marjo-Riitta ; Männikkö, Minna ; Laivuori, Hannele ; Palotie, Aarno ; Salomaa, Veikko ; Laakso, Markku ; Ripatti, Samuli. / Exome sequencing of Finnish isolates enhances rare-variant association power. In: Nature. 2019 ; Vol. 572, No. 7769. pp. 323–+.
@article{015fa276d72448599467f07a502abe30,
title = "Exome sequencing of Finnish isolates enhances rare-variant association power",
keywords = "GENOME-WIDE ASSOCIATION, LOW-FREQUENCY, MISSING HERITABILITY, CARDIOVASCULAR RISK, BLOOD-PRESSURE, DISEASE, TRAITS, CHOLESTEROL, POPULATION, PREDICTION, 3142 Public health care science, environmental and occupational health, 111 Mathematics",
author = "{FinnGen Project} and Locke, {Adam E.} and Steinberg, {Karyn Meltz} and Chiang, {Charleston W. K.} and Service, {Susan K.} and Havulinna, {Aki S.} and Laurel Stell and Matti Pirinen and Abel, {Haley J.} and Chiang, {Colby C.} and Fulton, {Robert S.} and Jackson, {Anne U.} and Kang, {Chul Joo} and Kanchi, {Krishna L.} and Koboldt, {Daniel C.} and Larson, {David E.} and Joanne Nelson and Nicholas, {Thomas J.} and Arto Pietila and Vasily Ramensky and Debashree Ray and Scott, {Laura J.} and Stringham, {Heather M.} and Jagadish Vangipurapu and Ryan Welch and Pranav Yajnik and Xianyong Yin and Eriksson, {Johan G.} and Mika Ala-Korpela and Marjo-Riitta J{\"a}rvelin and Minna M{\"a}nnikk{\"o} and Hannele Laivuori and Dutcher, {Susan K.} and Stitziel, {Nathan O.} and Wilson, {Richard K.} and Hall, {Ira M.} and Chiara Sabatti and Aarno Palotie and Veikko Salomaa and Markku Laakso and Samuli Ripatti and Michael Boehnke and Freimer, {Nelson B.}",
year = "2019",
month = "8",
day = "15",
doi = "10.1038/s41586-019-1457-z",
language = "English",
volume = "572",
pages = "323–+",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
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FinnGen Project, Locke, AE, Havulinna, AS, Pirinen, M, Eriksson, JG, Ala-Korpela, M, Järvelin, M-R, Männikkö, M, Laivuori, H, Palotie, A, Salomaa, V, Laakso, M & Ripatti, S 2019, 'Exome sequencing of Finnish isolates enhances rare-variant association power', Nature, vol. 572, no. 7769, pp. 323–+. https://doi.org/10.1038/s41586-019-1457-z

Exome sequencing of Finnish isolates enhances rare-variant association power. / FinnGen Project; Locke, Adam E.; Havulinna, Aki S.; Pirinen, Matti; Eriksson, Johan G.; Ala-Korpela, Mika; Järvelin, Marjo-Riitta; Männikkö, Minna; Laivuori, Hannele; Palotie, Aarno; Salomaa, Veikko; Laakso, Markku; Ripatti, Samuli.

In: Nature, Vol. 572, No. 7769, 15.08.2019, p. 323–+.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Exome sequencing of Finnish isolates enhances rare-variant association power

AU - FinnGen Project

AU - Locke, Adam E.

AU - Steinberg, Karyn Meltz

AU - Chiang, Charleston W. K.

AU - Service, Susan K.

AU - Havulinna, Aki S.

AU - Stell, Laurel

AU - Pirinen, Matti

AU - Abel, Haley J.

AU - Chiang, Colby C.

AU - Fulton, Robert S.

AU - Jackson, Anne U.

AU - Kang, Chul Joo

AU - Kanchi, Krishna L.

AU - Koboldt, Daniel C.

AU - Larson, David E.

AU - Nelson, Joanne

AU - Nicholas, Thomas J.

AU - Pietila, Arto

AU - Ramensky, Vasily

AU - Ray, Debashree

AU - Scott, Laura J.

AU - Stringham, Heather M.

AU - Vangipurapu, Jagadish

AU - Welch, Ryan

AU - Yajnik, Pranav

AU - Yin, Xianyong

AU - Eriksson, Johan G.

AU - Ala-Korpela, Mika

AU - Järvelin, Marjo-Riitta

AU - Männikkö, Minna

AU - Laivuori, Hannele

AU - Dutcher, Susan K.

AU - Stitziel, Nathan O.

AU - Wilson, Richard K.

AU - Hall, Ira M.

AU - Sabatti, Chiara

AU - Palotie, Aarno

AU - Salomaa, Veikko

AU - Laakso, Markku

AU - Ripatti, Samuli

AU - Boehnke, Michael

AU - Freimer, Nelson B.

PY - 2019/8/15

Y1 - 2019/8/15

KW - GENOME-WIDE ASSOCIATION

KW - LOW-FREQUENCY

KW - MISSING HERITABILITY

KW - CARDIOVASCULAR RISK

KW - BLOOD-PRESSURE

KW - DISEASE

KW - TRAITS

KW - CHOLESTEROL

KW - POPULATION

KW - PREDICTION

KW - 3142 Public health care science, environmental and occupational health

KW - 111 Mathematics

U2 - 10.1038/s41586-019-1457-z

DO - 10.1038/s41586-019-1457-z

M3 - Article

VL - 572

SP - 323–+

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7769

ER -