Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

Žiga Skok; Michaela Barančoková; Ondřej Benek; Cristina Durante Cruz; Päivi Tammela; Tihomir Tomašič; Nace Zidar; Lucija Peterlin Mašič; Anamarija Zega; Clare E. M. Stevenson; Julia E. A. Mundy; David M. Lawson; Anthony Maxwell; Danijel Kikelj; Janez Ilaš

doi:10.1021/acsmedchemlett.0c00416

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

Žiga Skok, Michaela Barančoková, Ondřej Benek, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Nace Zidar, Lucija Peterlin Mašič, Anamarija Zega, Clare E. M. Stevenson, Julia E. A. Mundy, David M. Lawson, Anthony Maxwell, Danijel Kikelj, Janez Ilaš

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	ACS Medicinal Chemistry Letters
Volume	11
Issue number	12
Pages (from-to)	2433-2440
Number of pages	8
ISSN	1948-5875
DOIs	https://doi.org/10.1021/acsmedchemlett.0c00416
Publication status	Published - 10 Dec 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

317 Pharmacy
DNA gyrase
topoisomerase IV
GyrB
ParE
antibacterial
benzothiazole
ANTIBACTERIAL ACTIVITY
N-PHENYLINDOLAMIDES
ATPASE INHIBITORS
DRUG DISCOVERY
KIBDELOMYCIN
N-PHENYL-4,5-DIBROMOPYRROLAMIDES
TRANSLOCATION
AMYCOLAMICIN
CHALLENGES
RESISTANCE
DNA gyrase
topoisomerase IV
GyrB
ParE
antibacterial
benzothiazole
ANTIBACTERIAL ACTIVITY
N-PHENYLINDOLAMIDES
ATPASE INHIBITORS
DRUG DISCOVERY
KIBDELOMYCIN
N-PHENYL-4,5-DIBROMOPYRROLAMIDES
TRANSLOCATION
AMYCOLAMICIN
CHALLENGES
RESISTANCE

Access to Document

10.1021/acsmedchemlett.0c00416

Skok et al 2020 AcceptedAccepted author manuscript, 500 KB

EC-FP7-KBBE-2009-3-2-01-245137: Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications (MAREX)
Kiuru, P., Lipiäinen, T., Tammela, P., Montalvão, S., Lillsunde, K., Vuorela, H. & Yli-Kauhaluoma, J.
01/08/2010 → 31/07/2014
Project: Research project

Cite this

Skok, Ž., Barančoková, M., Benek, O., Cruz, C. D., Tammela, P., Tomašič, T., Zidar, N., Mašič, L. P., Zega, A., Stevenson, C. E. M., Mundy, J. E. A., Lawson, D. M., Maxwell, A., Kikelj, D., & Ilaš, J. (2020). Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors. ACS Medicinal Chemistry Letters, 11(12), 2433-2440. https://doi.org/10.1021/acsmedchemlett.0c00416

@article{d3708b4e5bc1469582fc84d142763631,

title = "Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors",

keywords = "317 Pharmacy, DNA gyrase, topoisomerase IV, GyrB, ParE, antibacterial, benzothiazole, ANTIBACTERIAL ACTIVITY, N-PHENYLINDOLAMIDES, ATPASE INHIBITORS, DRUG DISCOVERY, KIBDELOMYCIN, N-PHENYL-4,5-DIBROMOPYRROLAMIDES, TRANSLOCATION, AMYCOLAMICIN, CHALLENGES, RESISTANCE, DNA gyrase, topoisomerase IV, GyrB, ParE, antibacterial, benzothiazole, ANTIBACTERIAL ACTIVITY, N-PHENYLINDOLAMIDES, ATPASE INHIBITORS, DRUG DISCOVERY, KIBDELOMYCIN, N-PHENYL-4,5-DIBROMOPYRROLAMIDES, TRANSLOCATION, AMYCOLAMICIN, CHALLENGES, RESISTANCE",

author = "{\v Z}iga Skok and Michaela Baran{\v c}okov{\'a} and Ond{\v r}ej Benek and Cruz, {Cristina Durante} and P{\"a}ivi Tammela and Tihomir Toma{\v s}i{\v c} and Nace Zidar and Ma{\v s}i{\v c}, {Lucija Peterlin} and Anamarija Zega and Stevenson, {Clare E. M.} and Mundy, {Julia E. A.} and Lawson, {David M.} and Anthony Maxwell and Danijel Kikelj and Janez Ila{\v s}",

note = "doi: 10.1021/acsmedchemlett.0c00416",

year = "2020",

month = dec,

day = "10",

doi = "10.1021/acsmedchemlett.0c00416",

language = "English",

volume = "11",

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journal = "ACS Medicinal Chemistry Letters",

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Skok, Ž, Barančoková, M, Benek, O, Cruz, CD , Tammela, P, Tomašič, T, Zidar, N, Mašič, LP, Zega, A, Stevenson, CEM, Mundy, JEA, Lawson, DM, Maxwell, A, Kikelj, D & Ilaš, J 2020, 'Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors', ACS Medicinal Chemistry Letters, vol. 11, no. 12, pp. 2433-2440. https://doi.org/10.1021/acsmedchemlett.0c00416

TY - JOUR

T1 - Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

AU - Skok, Žiga

AU - Barančoková, Michaela

AU - Benek, Ondřej

AU - Cruz, Cristina Durante

AU - Tammela, Päivi

AU - Tomašič, Tihomir

AU - Zidar, Nace

AU - Mašič, Lucija Peterlin

AU - Zega, Anamarija

AU - Stevenson, Clare E. M.

AU - Mundy, Julia E. A.

AU - Lawson, David M.

AU - Maxwell, Anthony

AU - Kikelj, Danijel

AU - Ilaš, Janez

N1 - doi: 10.1021/acsmedchemlett.0c00416

PY - 2020/12/10

Y1 - 2020/12/10

KW - 317 Pharmacy

KW - DNA gyrase

KW - topoisomerase IV

KW - GyrB

KW - ParE

KW - antibacterial

KW - benzothiazole

KW - ANTIBACTERIAL ACTIVITY

KW - N-PHENYLINDOLAMIDES

KW - ATPASE INHIBITORS

KW - DRUG DISCOVERY

KW - KIBDELOMYCIN

KW - N-PHENYL-4,5-DIBROMOPYRROLAMIDES

KW - TRANSLOCATION

KW - AMYCOLAMICIN

KW - CHALLENGES

KW - RESISTANCE

KW - DNA gyrase

KW - topoisomerase IV

KW - GyrB

KW - ParE

KW - antibacterial

KW - benzothiazole

KW - ANTIBACTERIAL ACTIVITY

KW - N-PHENYLINDOLAMIDES

KW - ATPASE INHIBITORS

KW - DRUG DISCOVERY

KW - KIBDELOMYCIN

KW - N-PHENYL-4,5-DIBROMOPYRROLAMIDES

KW - TRANSLOCATION

KW - AMYCOLAMICIN

KW - CHALLENGES

KW - RESISTANCE

U2 - 10.1021/acsmedchemlett.0c00416

DO - 10.1021/acsmedchemlett.0c00416

M3 - Article

VL - 11

SP - 2433

EP - 2440

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

SN - 1948-5875

IS - 12

ER -

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

Fields of Science

Access to Document

Projects

EC-FP7-KBBE-2009-3-2-01-245137: Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications (MAREX)

Cite this