Expression of the androgen receptor and syndecan-1 in breast tissue during different hormonal treatments in cynomolgus monkeys

Marie Hofling, Lin Ma, Lena Sahlin, Caj Haglund, Stig Nordling, Bo von Schoultz, J. Mark Cline

Research output: Contribution to journalArticleScientificpeer-review


Objectives To analyze the expression of the androgen receptor(AR) and syndecan-1 in breast tissue during long-term hormonal treatment in cynomolgus monkeys. Methods Sixty oophorectomized macaques were randomized to receive either tibolone, conjugated equine estrogens (CEE), CEE + medroxyprogesterone acetate (MPA) or no hormonal treatment. Breast tissue was collected at necropsy after 2 years and stained for AR and syndecan-1. Results Apparent differences were seen between treatment groups as compared to untreated animals. AR expression was markedly increased by tibolone and suppressed by combined CEE/MPA. Both treatments increased syndecan-1 in stromal tissue, whereas CEE alone had no significant effect. Conclusions We found alternative regimens for hormonal therapy to differ in their influence on two markers of importance for the development of breast cancer. The results may be relevant for the ongoing clinical discussion on the long-term safety of different hormonal treatments.
Original languageEnglish
Issue number1
Pages (from-to)72-79
Number of pages8
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

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