Abstract
| Original language | English |
|---|---|
| Journal | Pediatric Blood & Cancer |
| Volume | 48 |
| Issue number | 4 |
| Pages (from-to) | 387-392 |
| Number of pages | 6 |
| ISSN | 1545-5009 |
| DOIs | |
| Publication status | Published - 2007 |
| MoE publication type | A1 Journal article-refereed |
Fields of Science
- 3121 Internal medicine
- 3123 Gynaecology and paediatrics
- 3122 Cancers
Cite this
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Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells. / Kivivuori, Sanna-Maria; Siitonen, Sanna ; Porkka, Kimmo; Vettenranta, Kim; Alitalo, Riitta; Saarinen-Pihkala, Ulla M.
In: Pediatric Blood & Cancer, Vol. 48, No. 4, 2007, p. 387-392.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells
AU - Kivivuori, Sanna-Maria
AU - Siitonen, Sanna
AU - Porkka, Kimmo
AU - Vettenranta, Kim
AU - Alitalo, Riitta
AU - Saarinen-Pihkala, Ulla M.
PY - 2007
Y1 - 2007
N2 - "Background. Recent data indicate a role for angiogenesis in hematologic malignancies. In addition to promoting new vessel growth in the bone marrow microenvironment, angiogenic factors are regulators of both hematopoietic and leukemic cells. Activation of vascular endothelial growth factor receptor 3 (VEGFR-3) and Tiel tyrosine kinase receptor are known to promote leukemia cell survival. The details of this complex angiogenesis-related interaction are still uncertain. Procedure. We studied bone marrow samples from 73 patients with acute lymphoblastic (ALL) or myelogenous (AML) leukemia by using immunological methods. Results. Vascular endothelial growth factor receptor 3 expression was found in 15% of the samples, particularly in samples with pediatric lymphoblastic leukemias and monocytic AMLs. Tiel protein expression was found in 11% of the samples, all of which were from adult AML patients. Conclusions. Our findings suggest that there are angiogenesis-related differences between pediatric and adult lymphoblastic leukemias as well as between lymphoid and myeloid leukemias. Pediatr Blood Cancer 2007;48:387-392. (c) 2006 Wiley-Liss, Inc."
AB - "Background. Recent data indicate a role for angiogenesis in hematologic malignancies. In addition to promoting new vessel growth in the bone marrow microenvironment, angiogenic factors are regulators of both hematopoietic and leukemic cells. Activation of vascular endothelial growth factor receptor 3 (VEGFR-3) and Tiel tyrosine kinase receptor are known to promote leukemia cell survival. The details of this complex angiogenesis-related interaction are still uncertain. Procedure. We studied bone marrow samples from 73 patients with acute lymphoblastic (ALL) or myelogenous (AML) leukemia by using immunological methods. Results. Vascular endothelial growth factor receptor 3 expression was found in 15% of the samples, particularly in samples with pediatric lymphoblastic leukemias and monocytic AMLs. Tiel protein expression was found in 11% of the samples, all of which were from adult AML patients. Conclusions. Our findings suggest that there are angiogenesis-related differences between pediatric and adult lymphoblastic leukemias as well as between lymphoid and myeloid leukemias. Pediatr Blood Cancer 2007;48:387-392. (c) 2006 Wiley-Liss, Inc."
KW - 3121 Internal medicine
KW - 3123 Gynaecology and paediatrics
KW - 3122 Cancers
U2 - 10.1002/pbc.20857
DO - 10.1002/pbc.20857
M3 - Article
VL - 48
SP - 387
EP - 392
JO - Pediatric Blood & Cancer
JF - Pediatric Blood & Cancer
SN - 1545-5009
IS - 4
ER -