Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

Minna Lehtisalo; Jenni E. Keskitalo; Aleksi Tornio; Outi Lapatto-Reiniluoto; Feng Deng; Taina Jaatinen; Jenni Viinamäki; Mikko Neuvonen; Janne T. Backman; Mikko Niemi

doi:10.1111/cts.12809

Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

Minna Lehtisalo, Jenni E. Keskitalo, Aleksi Tornio, Outi Lapatto-Reiniluoto, Feng Deng, Taina Jaatinen, Jenni Viinamäki, Mikko Neuvonen, Janne T. Backman, Mikko Niemi

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Clinical and translational science
Volume	13
Issue number	6
Pages (from-to)	1236-1243
Number of pages	8
ISSN	1752-8054
DOIs	https://doi.org/10.1111/cts.12809
Publication status	Published - Nov 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

DRUG-DRUG INTERACTION
HEPATIC-UPTAKE
ABCG2 BCRP
PHARMACOKINETICS
TRANSPORTER
GOUT
ELTROMBOPAG
OATP1B1
RISK
ATORVASTATIN
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1111/cts.12809

cts.12809Final published version, 612 KBLicence: CC BY-NC

Cite this

Lehtisalo, M., Keskitalo, J. E., Tornio, A., Lapatto-Reiniluoto, O., Deng, F., Jaatinen, T., Viinamäki, J., Neuvonen, M., Backman, J. T., & Niemi, M. (2020). Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin. Clinical and translational science , 13(6), 1236-1243. https://doi.org/10.1111/cts.12809

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title = "Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin",

keywords = "DRUG-DRUG INTERACTION, HEPATIC-UPTAKE, ABCG2 BCRP, PHARMACOKINETICS, TRANSPORTER, GOUT, ELTROMBOPAG, OATP1B1, RISK, ATORVASTATIN, 3111 Biomedicine, 3121 General medicine, internal medicine and other clinical medicine",

author = "Minna Lehtisalo and Keskitalo, {Jenni E.} and Aleksi Tornio and Outi Lapatto-Reiniluoto and Feng Deng and Taina Jaatinen and Jenni Viinam{\"a}ki and Mikko Neuvonen and Backman, {Janne T.} and Mikko Niemi",

year = "2020",

month = nov,

doi = "10.1111/cts.12809",

language = "English",

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Lehtisalo, M , Keskitalo, JE , Tornio, A , Lapatto-Reiniluoto, O , Deng, F, Jaatinen, T, Viinamäki, J, Neuvonen, M, Backman, JT & Niemi, M 2020, 'Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin', Clinical and translational science , vol. 13, no. 6, pp. 1236-1243. https://doi.org/10.1111/cts.12809

TY - JOUR

T1 - Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

AU - Lehtisalo, Minna

AU - Keskitalo, Jenni E.

AU - Tornio, Aleksi

AU - Lapatto-Reiniluoto, Outi

AU - Deng, Feng

AU - Jaatinen, Taina

AU - Viinamäki, Jenni

AU - Neuvonen, Mikko

AU - Backman, Janne T.

AU - Niemi, Mikko

PY - 2020/11

Y1 - 2020/11

KW - DRUG-DRUG INTERACTION

KW - HEPATIC-UPTAKE

KW - ABCG2 BCRP

KW - PHARMACOKINETICS

KW - TRANSPORTER

KW - GOUT

KW - ELTROMBOPAG

KW - OATP1B1

KW - RISK

KW - ATORVASTATIN

KW - 3111 Biomedicine

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1111/cts.12809

DO - 10.1111/cts.12809

M3 - Article

VL - 13

SP - 1236

EP - 1243

JO - Clinical and translational science

JF - Clinical and translational science

SN - 1752-8054

IS - 6

ER -