First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis

Mari Karimaa; Reetta Riikonen; Henna Kettunen; Päivi Taavitsainen; Meri Ramela; Marcin Chrusciel; Stefan Karlsson; Petteri Rummakko; Outi Simola; Gerd Wohlfahrt; Pasi Hakulinen; Annamari Vuorela; Heikki Joensuu; Tapio Utriainen; Karim Fizazi; Riikka Oksala

doi:10.1158/1535-7163.MCT-22-0115

First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis

Mari Karimaa, Reetta Riikonen, Henna Kettunen, Päivi Taavitsainen, Meri Ramela, Marcin Chrusciel, Stefan Karlsson, Petteri Rummakko, Outi Simola, Gerd Wohlfahrt, Pasi Hakulinen, Annamari Vuorela, Heikki Joensuu, Tapio Utriainen, Karim Fizazi, Riikka Oksala

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Molecular Cancer Therapeutics
Volume	21
Issue number	12
Pages (from-to)	1765-1776
Number of pages	12
ISSN	1535-7163
DOIs	https://doi.org/10.1158/1535-7163.MCT-22-0115
Publication status	Published - Dec 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

3122 Cancers

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10.1158/1535-7163.MCT-22-0115

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Karimaa, M., Riikonen, R., Kettunen, H., Taavitsainen, P., Ramela, M., Chrusciel, M., Karlsson, S., Rummakko, P., Simola, O., Wohlfahrt, G., Hakulinen, P., Vuorela, A., Joensuu, H., Utriainen, T., Fizazi, K., & Oksala, R. (2022). First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis. Molecular Cancer Therapeutics, 21(12), 1765-1776. https://doi.org/10.1158/1535-7163.MCT-22-0115

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title = "First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis",

keywords = "Resistant prostate-cancer, Amino-acid substitution, Androgen-receptor gene, In-vitro, Ligand responsiveness, Expression, Abiraterone, Carcinoma, Mutation, Steroidogenesis, 3122 Cancers",

author = "Mari Karimaa and Reetta Riikonen and Henna Kettunen and P{\"a}ivi Taavitsainen and Meri Ramela and Marcin Chrusciel and Stefan Karlsson and Petteri Rummakko and Outi Simola and Gerd Wohlfahrt and Pasi Hakulinen and Annamari Vuorela and Heikki Joensuu and Tapio Utriainen and Karim Fizazi and Riikka Oksala",

year = "2022",

month = dec,

doi = "10.1158/1535-7163.MCT-22-0115",

language = "English",

volume = "21",

pages = "1765--1776",

journal = "Molecular Cancer Therapeutics",

issn = "1535-7163",

publisher = "American Association for Cancer Research",

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Karimaa, M, Riikonen, R, Kettunen, H, Taavitsainen, P, Ramela, M, Chrusciel, M, Karlsson, S, Rummakko, P, Simola, O, Wohlfahrt, G, Hakulinen, P, Vuorela, A, Joensuu, H , Utriainen, T, Fizazi, K & Oksala, R 2022, 'First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis', Molecular Cancer Therapeutics, vol. 21, no. 12, pp. 1765-1776. https://doi.org/10.1158/1535-7163.MCT-22-0115

TY - JOUR

T1 - First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis

AU - Karimaa, Mari

AU - Riikonen, Reetta

AU - Kettunen, Henna

AU - Taavitsainen, Päivi

AU - Ramela, Meri

AU - Chrusciel, Marcin

AU - Karlsson, Stefan

AU - Rummakko, Petteri

AU - Simola, Outi

AU - Wohlfahrt, Gerd

AU - Hakulinen, Pasi

AU - Vuorela, Annamari

AU - Joensuu, Heikki

AU - Utriainen, Tapio

AU - Fizazi, Karim

AU - Oksala, Riikka

PY - 2022/12

Y1 - 2022/12

KW - Resistant prostate-cancer

KW - Amino-acid substitution

KW - Androgen-receptor gene

KW - In-vitro

KW - Ligand responsiveness

KW - Expression

KW - Abiraterone

KW - Carcinoma

KW - Mutation

KW - Steroidogenesis

KW - 3122 Cancers

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uh_pure&SrcAuth=WosAPI&KeyUT=WOS:000892756400001&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.1158/1535-7163.MCT-22-0115

DO - 10.1158/1535-7163.MCT-22-0115

M3 - Article

C2 - 36129801

SN - 1535-7163

VL - 21

SP - 1765

EP - 1776

JO - Molecular Cancer Therapeutics

JF - Molecular Cancer Therapeutics

IS - 12

ER -

First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis

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