From Cytoskeleton to Gene Expression: Actin in the Nucleus

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Abstract

Although most people still associate actin mainly to the cytoskeleton, several lines of evidence, with the earliest studies dating back to decades ago, have emphasized the importance of actin also inside the cell nucleus. Actin has been linked to many gene expression processes from gene activation to chromatin remodeling, but also to maintenance of genomic integrity and intranuclear movement of chromosomes and chromosomal loci. Recent advances in visualizing different forms and dynamic properties of nuclear actin have clearly advanced our understanding of the basic concepts by which actin operates in the nucleus. In this chapter we address the different breakthroughs in nuclear actin studies, as well as discuss the regulation nuclear actin and the importance of nuclear actin dynamics in relation to its different nuclear functions. Our aim is to highlight the fact that actin should be considered as an essential component of the cell nucleus, and its nuclear actions should be taken into account also in experiments on cytoplasmic actin networks.
Translated title of the contributionSolun tukirangan säätelytehtävistä geenien säätelyyn: Aktiinin merkitys tumassa
Original languageEnglish
Title of host publicationThe Actin Cytoskeleton
EditorsBrigitte M. Jockusch
Number of pages18
Volume235
PublisherSpringer
Publication date2017
Edition1
Pages311-329
ISBN (Print)978-3-319-46369-8
ISBN (Electronic)978-3-319-46371-1
DOIs
Publication statusPublished - 2017
MoE publication typeB2 Book chapter

Publication series

NameHandbook of Experimental Pharmacology
PublisherSpringer International Publishing
Volume235
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

Cite this

Viita, T. K., & Vartiainen, M. K. (2017). From Cytoskeleton to Gene Expression: Actin in the Nucleus. In B. M. Jockusch (Ed.), The Actin Cytoskeleton (1 ed., Vol. 235, pp. 311-329). (Handbook of Experimental Pharmacology; Vol. 235). Springer. https://doi.org/10.1007/164_2016_27
Viita, Tiina Katriina ; Vartiainen, Maria Kristina. / From Cytoskeleton to Gene Expression: Actin in the Nucleus. The Actin Cytoskeleton. editor / Brigitte M. Jockusch. Vol. 235 1. ed. Springer, 2017. pp. 311-329 (Handbook of Experimental Pharmacology).
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Viita, TK & Vartiainen, MK 2017, From Cytoskeleton to Gene Expression: Actin in the Nucleus. in BM Jockusch (ed.), The Actin Cytoskeleton. 1 edn, vol. 235, Handbook of Experimental Pharmacology, vol. 235, Springer, pp. 311-329. https://doi.org/10.1007/164_2016_27

From Cytoskeleton to Gene Expression: Actin in the Nucleus. / Viita, Tiina Katriina; Vartiainen, Maria Kristina.

The Actin Cytoskeleton. ed. / Brigitte M. Jockusch. Vol. 235 1. ed. Springer, 2017. p. 311-329 (Handbook of Experimental Pharmacology; Vol. 235).

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

TY - CHAP

T1 - From Cytoskeleton to Gene Expression: Actin in the Nucleus

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PY - 2017

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AB - Although most people still associate actin mainly to the cytoskeleton, several lines of evidence, with the earliest studies dating back to decades ago, have emphasized the importance of actin also inside the cell nucleus. Actin has been linked to many gene expression processes from gene activation to chromatin remodeling, but also to maintenance of genomic integrity and intranuclear movement of chromosomes and chromosomal loci. Recent advances in visualizing different forms and dynamic properties of nuclear actin have clearly advanced our understanding of the basic concepts by which actin operates in the nucleus. In this chapter we address the different breakthroughs in nuclear actin studies, as well as discuss the regulation nuclear actin and the importance of nuclear actin dynamics in relation to its different nuclear functions. Our aim is to highlight the fact that actin should be considered as an essential component of the cell nucleus, and its nuclear actions should be taken into account also in experiments on cytoplasmic actin networks.

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Viita TK, Vartiainen MK. From Cytoskeleton to Gene Expression: Actin in the Nucleus. In Jockusch BM, editor, The Actin Cytoskeleton. 1 ed. Vol. 235. Springer. 2017. p. 311-329. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/164_2016_27