Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

Sanna Pikkusaari; Manuela Tumiati; Anni Virtanen; Jaana Oikkonen; Yilin Li; Fernando Perez-Villatoro; Taru Muranen; Matilda Salko; Kaisa Huhtinen; Anna Kanerva; Heidi Koskela; Johanna Tapper; Riitta Koivisto-Korander; Titta Joutsiniemi; Ulla-Maija Haltia; Heini Lassus; Sampsa Hautaniemi; Anniina Färkkilä; Johanna Hynninen; Sakari Hietanen; Olli Carpen; Liisa Kauppi

doi:10.1158/1078-0432.CCR-22-3156

Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

Sanna Pikkusaari, Manuela Tumiati, Anni Virtanen, Jaana Oikkonen, Yilin Li, Fernando Perez-Villatoro, Taru Muranen, Matilda Salko, Kaisa Huhtinen, Anna Kanerva, Heidi Koskela, Johanna Tapper, Riitta Koivisto-Korander, Titta Joutsiniemi, Ulla-Maija Haltia, Heini Lassus, Sampsa Hautaniemi, Anniina Färkkilä, Johanna Hynninen, Sakari HietanenOlli Carpen, Liisa Kauppi

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Clinical Cancer Research
Volume	29
Issue number	16
Pages (from-to)	3110-3123
Number of pages	14
ISSN	1078-0432
DOIs	https://doi.org/10.1158/1078-0432.CCR-22-3156
Publication status	Published - 15 Aug 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

3122 Cancers

Access to Document

10.1158/1078-0432.CCR-22-3156

ccr-22-3156Final published version, 5.62 MBLicence: CC BY

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer
Färkkilä, A. (Project manager), Kang, Z. (Participant), Niemiec, I. (Participant), Nagaraj, A. (Participant), Perez Villatoro, F. R. (Participant), Chernenko, A. (Participant) & Shah, S. (Participant)
01/01/2021 → 31/12/2023
Project: University of Helsinki Three-Year Research Project

iCAN Ovarian Cancer Subproject coordinator
Färkkilä, A. (Participant)
2021 → …
Activity: Other activity types › Other

Cite this

Pikkusaari, S., Tumiati, M., Virtanen, A., Oikkonen, J., Li, Y., Perez-Villatoro, F., Muranen, T., Salko, M., Huhtinen, K., Kanerva, A., Koskela, H., Tapper, J., Koivisto-Korander, R., Joutsiniemi, T., Haltia, U.-M., Lassus, H., Hautaniemi, S., Färkkilä, A., Hynninen, J., ... Kauppi, L. (2023). Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes. Clinical Cancer Research, 29(16), 3110-3123. https://doi.org/10.1158/1078-0432.CCR-22-3156

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title = "Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes",

keywords = "Somatic mutations, Double-blind, Platinum, Deficiency, Maintenance, Tumors, Therapy, Recommendations, Identification, Chemotherapy, 3122 Cancers",

author = "Sanna Pikkusaari and Manuela Tumiati and Anni Virtanen and Jaana Oikkonen and Yilin Li and Fernando Perez-Villatoro and Taru Muranen and Matilda Salko and Kaisa Huhtinen and Anna Kanerva and Heidi Koskela and Johanna Tapper and Riitta Koivisto-Korander and Titta Joutsiniemi and Ulla-Maija Haltia and Heini Lassus and Sampsa Hautaniemi and Anniina F{\"a}rkkil{\"a} and Johanna Hynninen and Sakari Hietanen and Olli Carpen and Liisa Kauppi",

year = "2023",

month = aug,

day = "15",

doi = "10.1158/1078-0432.CCR-22-3156",

language = "English",

volume = "29",

pages = "3110--3123",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

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}

Pikkusaari, S, Tumiati, M, Virtanen, A , Oikkonen, J, Li, Y, Perez-Villatoro, F , Muranen, T , Salko, M, Huhtinen, K, Kanerva, A, Koskela, H, Tapper, J, Koivisto-Korander, R, Joutsiniemi, T, Haltia, U-M, Lassus, H, Hautaniemi, S , Färkkilä, A, Hynninen, J, Hietanen, S, Carpen, O & Kauppi, L 2023, 'Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes', Clinical Cancer Research, vol. 29, no. 16, pp. 3110-3123. https://doi.org/10.1158/1078-0432.CCR-22-3156

TY - JOUR

T1 - Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

AU - Pikkusaari, Sanna

AU - Tumiati, Manuela

AU - Virtanen, Anni

AU - Oikkonen, Jaana

AU - Li, Yilin

AU - Perez-Villatoro, Fernando

AU - Muranen, Taru

AU - Salko, Matilda

AU - Huhtinen, Kaisa

AU - Kanerva, Anna

AU - Koskela, Heidi

AU - Tapper, Johanna

AU - Koivisto-Korander, Riitta

AU - Joutsiniemi, Titta

AU - Haltia, Ulla-Maija

AU - Lassus, Heini

AU - Hautaniemi, Sampsa

AU - Färkkilä, Anniina

AU - Hynninen, Johanna

AU - Hietanen, Sakari

AU - Carpen, Olli

AU - Kauppi, Liisa

PY - 2023/8/15

Y1 - 2023/8/15

KW - Somatic mutations

KW - Double-blind

KW - Platinum

KW - Deficiency

KW - Maintenance

KW - Tumors

KW - Therapy

KW - Recommendations

KW - Identification

KW - Chemotherapy

KW - 3122 Cancers

U2 - 10.1158/1078-0432.CCR-22-3156

DO - 10.1158/1078-0432.CCR-22-3156

M3 - Article

C2 - 36805632

SN - 1078-0432

VL - 29

SP - 3110

EP - 3123

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 16

ER -

Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

Fields of Science

Access to Document

Projects

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer

Activities

iCAN Ovarian Cancer Subproject coordinator

Cite this