Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Diego Balboa; Tom Barsby; Väinö Lithovius; Jonna Saarimäki-Vire; Muhmmad Omar-Hmeadi; Oleg Dyachok; Hossam Montaser; Per-Eric Lund; Mingyu Yang; Hazem Ibrahim; Anna Näätänen; Vikash Chandra; Helena Vihinen; Eija Jokitalo; Jouni Kvist; Jarkko Ustinov; Anni Nieminen; Emilia Kuuluvainen; Ville Hietakangas; Pekka Katajisto; Joey Lau; Per-Ola Carlsson; Sebastian Barg; Anders Tengholm; Timo Otonkoski

doi:10.1038/s41587-022-01219-z

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Diego Balboa, Tom Barsby, Väinö Lithovius, Jonna Saarimäki-Vire, Muhmmad Omar-Hmeadi, Oleg Dyachok, Hossam Montaser, Per-Eric Lund, Mingyu Yang, Hazem Ibrahim, Anna Näätänen, Vikash Chandra, Helena Vihinen, Eija Jokitalo, Jouni Kvist, Jarkko Ustinov, Anni Nieminen, Emilia Kuuluvainen, Ville Hietakangas, Pekka KatajistoJoey Lau, Per-Ola Carlsson, Sebastian Barg, Anders Tengholm, Timo Otonkoski

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature Biotechnology
Volume	40
Pages (from-to)	1042–1055
Number of pages	21
ISSN	1087-0156
DOIs	https://doi.org/10.1038/s41587-022-01219-z
Publication status	Published - Jul 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

BETA-CELL
INSULIN-SECRETION
IN-VITRO
GENERATION
PROGENITORS
ENRICHMENT
POPULATION
DYNAMICS
MOUSE
FATE
318 Medical biotechnology
11832 Microbiology and virology

Access to Document

10.1038/s41587-022-01219-z

Functional metabolic and transcriptional maturation of human pancreatic islets derived from stem cellsFinal published version, 6.05 MBLicence: CC BY

Cite this

Balboa, D., Barsby, T., Lithovius, V., Saarimäki-Vire, J., Omar-Hmeadi, M., Dyachok, O., Montaser, H., Lund, P.-E., Yang, M., Ibrahim, H., Näätänen, A., Chandra, V., Vihinen, H., Jokitalo, E., Kvist, J., Ustinov, J., Nieminen, A., Kuuluvainen, E., Hietakangas, V., ... Otonkoski, T. (2022). Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells. Nature Biotechnology, 40, 1042–1055. https://doi.org/10.1038/s41587-022-01219-z

@article{b369e3a6d6c14c32b567be5934dd62b9,

title = "Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells",

keywords = "BETA-CELL, INSULIN-SECRETION, IN-VITRO, GENERATION, PROGENITORS, ENRICHMENT, POPULATION, DYNAMICS, MOUSE, FATE, 318 Medical biotechnology, 11832 Microbiology and virology",

author = "Diego Balboa and Tom Barsby and V{\"a}in{\"o} Lithovius and Jonna Saarim{\"a}ki-Vire and Muhmmad Omar-Hmeadi and Oleg Dyachok and Hossam Montaser and Per-Eric Lund and Mingyu Yang and Hazem Ibrahim and Anna N{\"a}{\"a}t{\"a}nen and Vikash Chandra and Helena Vihinen and Eija Jokitalo and Jouni Kvist and Jarkko Ustinov and Anni Nieminen and Emilia Kuuluvainen and Ville Hietakangas and Pekka Katajisto and Joey Lau and Per-Ola Carlsson and Sebastian Barg and Anders Tengholm and Timo Otonkoski",

year = "2022",

month = jul,

doi = "10.1038/s41587-022-01219-z",

language = "English",

volume = "40",

pages = "1042–1055",

journal = "Nature Biotechnology",

issn = "1087-0156",

publisher = "Nature Publishing Group",

}

Balboa, D, Barsby, T, Lithovius, V , Saarimäki-Vire, J, Omar-Hmeadi, M, Dyachok, O, Montaser, H, Lund, P-E, Yang, M, Ibrahim, H, Näätänen, A, Chandra, V , Vihinen, H , Jokitalo, E , Kvist, J, Ustinov, J, Nieminen, A , Kuuluvainen, E , Hietakangas, V , Katajisto, P, Lau, J, Carlsson, P-O, Barg, S, Tengholm, A & Otonkoski, T 2022, 'Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells', Nature Biotechnology, vol. 40, pp. 1042–1055. https://doi.org/10.1038/s41587-022-01219-z

TY - JOUR

T1 - Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

AU - Balboa, Diego

AU - Barsby, Tom

AU - Lithovius, Väinö

AU - Saarimäki-Vire, Jonna

AU - Omar-Hmeadi, Muhmmad

AU - Dyachok, Oleg

AU - Montaser, Hossam

AU - Lund, Per-Eric

AU - Yang, Mingyu

AU - Ibrahim, Hazem

AU - Näätänen, Anna

AU - Chandra, Vikash

AU - Vihinen, Helena

AU - Jokitalo, Eija

AU - Kvist, Jouni

AU - Ustinov, Jarkko

AU - Nieminen, Anni

AU - Kuuluvainen, Emilia

AU - Hietakangas, Ville

AU - Katajisto, Pekka

AU - Lau, Joey

AU - Carlsson, Per-Ola

AU - Barg, Sebastian

AU - Tengholm, Anders

AU - Otonkoski, Timo

PY - 2022/7

Y1 - 2022/7

KW - BETA-CELL

KW - INSULIN-SECRETION

KW - IN-VITRO

KW - GENERATION

KW - PROGENITORS

KW - ENRICHMENT

KW - POPULATION

KW - DYNAMICS

KW - MOUSE

KW - FATE

KW - 318 Medical biotechnology

KW - 11832 Microbiology and virology

U2 - 10.1038/s41587-022-01219-z

DO - 10.1038/s41587-022-01219-z

M3 - Article

SN - 1087-0156

VL - 40

SP - 1042

EP - 1055

JO - Nature Biotechnology

JF - Nature Biotechnology

ER -