Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals

Francisca Araújo, José das Neves, Joao Pedro Oliveira Martins, Pedro L. Granja, Helder Almeida Santos, Bruno Sarmento

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems.
Original languageEnglish
JournalProgress in Materials Science
Volume89
Pages (from-to)306–344
Number of pages39
ISSN0079-6425
DOIs
Publication statusPublished - Aug 2017
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy
  • Biomaterials
  • Multistage platforms
  • Biopharmaceuticals
  • Surface functionalization
  • Oral delivery

Cite this

Araújo, Francisca ; das Neves, José ; Oliveira Martins, Joao Pedro ; L. Granja, Pedro ; Almeida Santos, Helder ; Sarmento, Bruno. / Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals. In: Progress in Materials Science. 2017 ; Vol. 89. pp. 306–344.
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abstract = "Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems.",
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Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals. / Araújo, Francisca ; das Neves, José ; Oliveira Martins, Joao Pedro; L. Granja, Pedro ; Almeida Santos, Helder; Sarmento, Bruno.

In: Progress in Materials Science, Vol. 89, 08.2017, p. 306–344.

Research output: Contribution to journalReview ArticleScientificpeer-review

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AU - das Neves, José

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AU - Almeida Santos, Helder

AU - Sarmento, Bruno

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