Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias

Heikki Swan; Mohamed Yassine Amarouch; Jaakko Leinonen; Annukka Marjamaa; Jan P. Kucera; Päivi J. Laitinen-Forsblom; Annukka M. Lahtinen; Aarno Palotie; Kimmo Kontula; Lauri Toivonen; Hugues Abriel; Elisabeth Widen

doi:10.1161/CIRCGENETICS.114.000703

Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias

Heikki Swan, Mohamed Yassine Amarouch, Jaakko Leinonen, Annukka Marjamaa, Jan P. Kucera, Päivi J. Laitinen-Forsblom, Annukka M. Lahtinen, Aarno Palotie, Kimmo Kontula, Lauri Toivonen, Hugues Abriel, Elisabeth Widen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Circulation. Cardiovascular genetics
Volume	7
Issue number	6
Pages (from-to)	771-U111
Number of pages	17
ISSN	1942-325X
DOIs	https://doi.org/10.1161/CIRCGENETICS.114.000703
Publication status	Published - Dec 2014
MoE publication type	A1 Journal article-refereed

Fields of Science

arrhythmia (heart rhythm disorders)
catecholaminergic polymorphic ventricular tachycardia
exercise test
genetic testing
mutation
SCN5A
LONG QT SYNDROME
CARDIAC SODIUM-CHANNEL
BRUGADA-SYNDROME
CA2+ SPARK
IN-VITRO
TACHYCARDIA
MODEL
DISEASE
FAMILY
ERYTHROMELALGIA
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1161/CIRCGENETICS.114.000703

Cite this

Swan, H., Amarouch, M. Y., Leinonen, J., Marjamaa, A., Kucera, J. P., Laitinen-Forsblom, P. J., Lahtinen, A. M., Palotie, A., Kontula, K., Toivonen, L., Abriel, H., & Widen, E. (2014). Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias. Circulation. Cardiovascular genetics, 7(6), 771-U111. https://doi.org/10.1161/CIRCGENETICS.114.000703

@article{00e808fb2e2c4c569da47f0b0d4bfbc3,

title = "Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias",

keywords = "arrhythmia (heart rhythm disorders), catecholaminergic polymorphic ventricular tachycardia, exercise test, genetic testing, mutation, SCN5A, LONG QT SYNDROME, CARDIAC SODIUM-CHANNEL, BRUGADA-SYNDROME, CA2+ SPARK, IN-VITRO, TACHYCARDIA, MODEL, DISEASE, FAMILY, ERYTHROMELALGIA, 3121 General medicine, internal medicine and other clinical medicine",

author = "Heikki Swan and Amarouch, {Mohamed Yassine} and Jaakko Leinonen and Annukka Marjamaa and Kucera, {Jan P.} and Laitinen-Forsblom, {P{\"a}ivi J.} and Lahtinen, {Annukka M.} and Aarno Palotie and Kimmo Kontula and Lauri Toivonen and Hugues Abriel and Elisabeth Widen",

year = "2014",

month = dec,

doi = "10.1161/CIRCGENETICS.114.000703",

language = "English",

volume = "7",

pages = "771--U111",

journal = "Circulation. Cardiovascular genetics",

issn = "1942-325X",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

Swan, H, Amarouch, MY, Leinonen, J, Marjamaa, A, Kucera, JP, Laitinen-Forsblom, PJ, Lahtinen, AM , Palotie, A , Kontula, K, Toivonen, L, Abriel, H & Widen, E 2014, 'Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias', Circulation. Cardiovascular genetics, vol. 7, no. 6, pp. 771-U111. https://doi.org/10.1161/CIRCGENETICS.114.000703

TY - JOUR

T1 - Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias

AU - Swan, Heikki

AU - Amarouch, Mohamed Yassine

AU - Leinonen, Jaakko

AU - Marjamaa, Annukka

AU - Kucera, Jan P.

AU - Laitinen-Forsblom, Päivi J.

AU - Lahtinen, Annukka M.

AU - Palotie, Aarno

AU - Kontula, Kimmo

AU - Toivonen, Lauri

AU - Abriel, Hugues

AU - Widen, Elisabeth

PY - 2014/12

Y1 - 2014/12

KW - arrhythmia (heart rhythm disorders)

KW - catecholaminergic polymorphic ventricular tachycardia

KW - exercise test

KW - genetic testing

KW - mutation

KW - SCN5A

KW - LONG QT SYNDROME

KW - CARDIAC SODIUM-CHANNEL

KW - BRUGADA-SYNDROME

KW - CA2+ SPARK

KW - IN-VITRO

KW - TACHYCARDIA

KW - MODEL

KW - DISEASE

KW - FAMILY

KW - ERYTHROMELALGIA

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1161/CIRCGENETICS.114.000703

DO - 10.1161/CIRCGENETICS.114.000703

M3 - Article

SN - 1942-325X

VL - 7

SP - 771-U111

JO - Circulation. Cardiovascular genetics

JF - Circulation. Cardiovascular genetics

IS - 6

ER -