Gaining fluid bed process understanding by in-line particle size analysis

Tero Närvänen, Tanja Lipsanen, Osmo Antikainen, Heikki Räikkönen, Jyrki Heinämäki, Jouko Yliruusi

    Research output: Contribution to journalArticleScientificpeer-review


    Different process phenomena and process failure modes could be monitored using the in-line particle size data measured by spatial filtering technique (SFT). In addition to the real-time granule growth monitoring, other events, such as the blocking of filter bags and the distributor plate, could be observed. SFT was used off-line, at-line and in-line in 14 differently manufactured granulation batches. No significant fouling occurred during the manufacturing due to the appropriate positioning of the probe. The off-line SFT results correlated well (R-2 = 0.97) with the sieve analysis results. It was also found that size segregation influenced both the in-line and at-line particle size results during the fluidization: in-line method underestimated and at-line method overestimated the final particle size. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:1110-1117, 2009
    Original languageEnglish
    JournalJournal of Pharmaceutical Sciences
    Issue number3
    Pages (from-to)1110-1117
    Number of pages8
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

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