GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalArchives of Toxicology
Volume94
Issue number6
Pages (from-to)2113-2130
Number of pages18
ISSN0340-5761
DOIs
Publication statusPublished - Jun 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Doxorubicin
  • Cardiotoxicity
  • Human induced pluripotent stem cell-derived cardiomyocytes
  • Transcription factors
  • GATA4-targeted compounds
  • Cardioprotective
  • TRANSCRIPTION FACTORS GATA4
  • BRAIN NATRIURETIC PEPTIDE
  • INDUCED CARDIOMYOPATHY
  • GENE-EXPRESSION
  • CELL-SURVIVAL
  • CARDIAC HORMONES
  • POSITION PAPER
  • RAT
  • PHARMACOKINETICS
  • HYPERTROPHY
  • 1182 Biochemistry, cell and molecular biology
  • 317 Pharmacy

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