Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume94
Issue number3
Pages (from-to)383-393
Number of pages11
ISSN0009-9236
DOIs
Publication statusPublished - Sep 2013
MoE publication typeA1 Journal article-refereed

Fields of Science

  • CHRONIC MYELOID-LEUKEMIA
  • DRUG-DRUG INTERACTIONS
  • ST-JOHNS-WORT
  • PLASMA-CONCENTRATIONS
  • IMATINIB MESYLATE
  • HEALTHY-SUBJECTS
  • HEPATIC-UPTAKE
  • GLUCURONIDE INHIBIT
  • PROTEIN-BINDING
  • GIST PATIENTS
  • 317 Pharmacy

Cite this

@article{55143e281000402ba49e900a58c8471d,
title = "Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite",
keywords = "CHRONIC MYELOID-LEUKEMIA, DRUG-DRUG INTERACTIONS, ST-JOHNS-WORT, PLASMA-CONCENTRATIONS, IMATINIB MESYLATE, HEALTHY-SUBJECTS, HEPATIC-UPTAKE, GLUCURONIDE INHIBIT, PROTEIN-BINDING, GIST PATIENTS, 317 Pharmacy",
author = "Filppula, {A. M.} and A. Tornio and Mikko Niemi and Neuvonen, {P. J.} and Backman, {J. T.}",
year = "2013",
month = "9",
doi = "10.1038/clpt.2013.92",
language = "English",
volume = "94",
pages = "383--393",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Wiley",
number = "3",

}

TY - JOUR

T1 - Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

AU - Filppula, A. M.

AU - Tornio, A.

AU - Niemi, Mikko

AU - Neuvonen, P. J.

AU - Backman, J. T.

PY - 2013/9

Y1 - 2013/9

KW - CHRONIC MYELOID-LEUKEMIA

KW - DRUG-DRUG INTERACTIONS

KW - ST-JOHNS-WORT

KW - PLASMA-CONCENTRATIONS

KW - IMATINIB MESYLATE

KW - HEALTHY-SUBJECTS

KW - HEPATIC-UPTAKE

KW - GLUCURONIDE INHIBIT

KW - PROTEIN-BINDING

KW - GIST PATIENTS

KW - 317 Pharmacy

U2 - 10.1038/clpt.2013.92

DO - 10.1038/clpt.2013.92

M3 - Article

VL - 94

SP - 383

EP - 393

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 3

ER -