Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume88
Issue number2
Pages (from-to)223-230
Number of pages8
ISSN0009-9236
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fields of Science

  • LEUKOTRIENE-RECEPTOR ANTAGONIST
  • DRUG-DRUG INTERACTION
  • DOUBLE-BLIND-TRIAL
  • CYTOCHROME P4502C8
  • CHRONIC ASTHMA
  • HEPATIC-UPTAKE
  • PHARMACOKINETICS
  • POTENT
  • REPAGLINIDE
  • INHIBITION
  • 312 Clinical medicine

Cite this

@article{be9617b0843541339b931641fc8df7dc,
title = "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast",
keywords = "LEUKOTRIENE-RECEPTOR ANTAGONIST, DRUG-DRUG INTERACTION, DOUBLE-BLIND-TRIAL, CYTOCHROME P4502C8, CHRONIC ASTHMA, HEPATIC-UPTAKE, PHARMACOKINETICS, POTENT, REPAGLINIDE, INHIBITION, 312 Clinical medicine",
author = "Tiina Karonen and Anne Filppula and Jouko Laitila and Mikko Niemi and Neuvonen, {Pertti J.} and Backman, {Janne T.}",
year = "2010",
doi = "10.1038/clpt.2010.73",
language = "English",
volume = "88",
pages = "223--230",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Wiley",
number = "2",

}

TY - JOUR

T1 - Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

AU - Karonen, Tiina

AU - Filppula, Anne

AU - Laitila, Jouko

AU - Niemi, Mikko

AU - Neuvonen, Pertti J.

AU - Backman, Janne T.

PY - 2010

Y1 - 2010

KW - LEUKOTRIENE-RECEPTOR ANTAGONIST

KW - DRUG-DRUG INTERACTION

KW - DOUBLE-BLIND-TRIAL

KW - CYTOCHROME P4502C8

KW - CHRONIC ASTHMA

KW - HEPATIC-UPTAKE

KW - PHARMACOKINETICS

KW - POTENT

KW - REPAGLINIDE

KW - INHIBITION

KW - 312 Clinical medicine

U2 - 10.1038/clpt.2010.73

DO - 10.1038/clpt.2010.73

M3 - Article

VL - 88

SP - 223

EP - 230

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 2

ER -