Genetic diversity fuels gene discovery for tobacco and alcohol use

Gretchen R. B. Saunders; Xingyan Wang; Fang Chen; Seon-Kyeong Jang; Mengzhen Liu; Chen Wang; Shuang Gao; Yu Jiang; Chachrit Khunsriraksakul; Jacqueline M. Otto; Clifton Addison; Masato Akiyama; Christine M. Albert; Fazil Aliev; Alvaro Alonso; Donna K. Arnett; Allison E. Ashley-Koch; Aneel A. Ashrani; Kathleen C. Barnes; R. Graham Barr; Traci M. Bartz; Diane M. Becker; Lawrence F. Bielak; Emelia J. Benjamin; Joshua C. Bis; Gyda Bjornsdottir; John Blangero; Eugene R. Bleecker; Jason D. Boardman; Eric Boerwinkle; Dorret Boomsma; Meher Preethi Boorgula; Donald W. Bowden; Jennifer A. Brody; Brian E. Cade; Daniel Chasman; Sameer Chavan; Yii-Der Ida Chen; Zhengming Chen; Iona Cheng; Michael H. Cho; Helene Choquet; John W. Cole; Marilyn C. Cornelis; Francesco Cucca; Joanne E. Curran; Mariza de Andrade; Danielle M. Dick; Anna R. Docherty; Ravindranath Duggirala; Charles B. Eaton; Marissa A. Ehringer; Tonu Esko; Jessica D. Faul; Lilian Fernandes Silva; Edoardo Fiorillo; Myriam Fornage; Barry Freedman; Maiken E. Gabrielsen; Melanie E. Garrett; Sina A. Gharib; Christian Gieger; Nathan Gillespie; David C. Glahn; Scott D. Gordon; Charles C. Gu; Dongfeng Gu; Daniel F. Gudbjartsson; Xiuqing Guo; Jeffrey Haessler; Michael E. Hall; Toomas Haller; Kathleen Mullan Harris; Jiang He; Pamela Herd; John K. Hewitt; Ian Hickie; Bertha Hidalgo; John E. Hokanson; Christian Hopfer; JoukeJan Hottenga; Lifang Hou; Hongyan Huang; Yi-Jen Hung; David J. Hunter; Kristian Hveem; Shih-Jen Hwang; Chii-Min Hwu; William Iacono; Marguerite R. Irvin; Yon Ho Jee; Eric O. Johnson; Yoonjung Y. Joo; Eric Jorgenson; Anne E. Justice; Yoichiro Kamatani; Robert C. Kaplan; Jaakko Kaprio; Sharon L. R. Kardia; Matthew C. Keller; Tanika N. Kelly; Charles Kooperberg; Tellervo Korhonen; Peter Kraft; Kenneth Krauter; Johanna Kuusisto; Markku Laakso; Jessica Lasky-Su; Wen-Jane Lee; James J. Lee; Daniel Levy; Liming Li; Kevin Li; Yuqing Li; Kuang Lin; Penelope A. Lind; Chunyu Liu; Donald M. Lloyd-Jones; Sharon M. Lutz; Jiantao Ma; Reedik Magi; Ani Manichaikul; Nicholas G. Martin; Ravi Mathur; Nana Matoba; Patrick F. McArdle; Matt McGue; Matthew B. McQueen; Sarah E. Medland; Andres Metspalu; Deborah A. Meyers; Iona Y. Millwood; Braxton D. Mitchell; Karen L. Mohlke; Matthew Moll; May E. Montasser; Alanna C. Morrison; Antonella Mulas; Jonas B. Nielsen; Kari E. North; Elizabeth C. Oelsner; Yukinori Okada; Valeria Orru; Nicholette D. Palmer; Teemu Palviainen; Anita Pandit; S. Lani Park; Ulrike Peters; Annette Peters; Patricia A. Peyser; Tinca J. C. Polderman; Nicholas Rafaels; Susan Redline; Robert M. Reed; Alex P. Reiner; John P. Rice; Stephen S. Rich; Nicole E. Richmond; Carol Roan; Jerome Rotter; Michael N. Rueschman; Valgerdur Runarsdottir; Nancy L. Saccone; David A. Schwartz; Aladdin H. Shadyab; Jingchunzi Shi; Suyash S. Shringarpure; Kamil Sicinski; Anne Heidi Skogholt; Jennifer A. Smith; Nicholas L. Smith; Nona Sotoodehnia; Michael C. Stallings; Hreinn Stefansson; Kari Stefansson; Jerry A. Stitzel; Xiao Sun; Moin Syed; Ruth Tal-Singer; Amy E. Taylor; Kent D. Taylor; Marilyn J. Telen; Khanh K. Thai; Hemant Tiwari; Constance Turman; Thorarinn Tyrfingsson; Tamara L. Wall; Robin G. Walters; David R. Weir; Scott T. Weiss; Wendy B. White; John B. Whitfield; Kerri L. Wiggins; Gonneke Willemsen; Cristen J. Willer; Bendik S. Winsvold; Huichun Xu; Lisa R. Yanek; Jie Yin; Kristin L. Young; Kendra A. Young; Bing Yu; Wei Zhao; Wei Zhou; Sebastian Zollner; Luisa Zuccolo; The Biobank Japan Project; Chiara Batini; Andrew W. Bergen; Laura J. Bierut; Sean P. David; Sarah A. Gagliano Taliun; Dana B. Hancock; Bibo Jiang; Marcus R. Munafo; Thorgeir E. Thorgeirsson; Dajiang J. Liu; Scott Vrieze

doi:10.1038/s41586-022-05477-4

Genetic diversity fuels gene discovery for tobacco and alcohol use

Gretchen R. B. Saunders, Xingyan Wang, Fang Chen, Seon-Kyeong Jang, Mengzhen Liu, Chen Wang, Shuang Gao, Yu Jiang, Chachrit Khunsriraksakul, Jacqueline M. Otto, Clifton Addison, Masato Akiyama, Christine M. Albert, Fazil Aliev, Alvaro Alonso, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, R. Graham BarrTraci M. Bartz, Diane M. Becker, Lawrence F. Bielak, Emelia J. Benjamin, Joshua C. Bis, Gyda Bjornsdottir, John Blangero, Eugene R. Bleecker, Jason D. Boardman, Eric Boerwinkle, Dorret Boomsma, Meher Preethi Boorgula, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, Daniel Chasman, Sameer Chavan, Yii-Der Ida Chen, Zhengming Chen, Iona Cheng, Michael H. Cho, Helene Choquet, John W. Cole, Marilyn C. Cornelis, Francesco Cucca, Joanne E. Curran, Mariza de Andrade, Danielle M. Dick, Anna R. Docherty, Ravindranath Duggirala, Charles B. Eaton, Marissa A. Ehringer, Tonu Esko, Jessica D. Faul, Lilian Fernandes Silva, Edoardo Fiorillo, Myriam Fornage, Barry Freedman, Maiken E. Gabrielsen, Melanie E. Garrett, Sina A. Gharib, Christian Gieger, Nathan Gillespie, David C. Glahn, Scott D. Gordon, Charles C. Gu, Dongfeng Gu, Daniel F. Gudbjartsson, Xiuqing Guo, Jeffrey Haessler, Michael E. Hall, Toomas Haller, Kathleen Mullan Harris, Jiang He, Pamela Herd, John K. Hewitt, Ian Hickie, Bertha Hidalgo, John E. Hokanson, Christian Hopfer, JoukeJan Hottenga, Lifang Hou, Hongyan Huang, Yi-Jen Hung, David J. Hunter, Kristian Hveem, Shih-Jen Hwang, Chii-Min Hwu, William Iacono, Marguerite R. Irvin, Yon Ho Jee, Eric O. Johnson, Yoonjung Y. Joo, Eric Jorgenson, Anne E. Justice, Yoichiro Kamatani, Robert C. Kaplan, Jaakko Kaprio, Sharon L. R. Kardia, Matthew C. Keller, Tanika N. Kelly, Charles Kooperberg, Tellervo Korhonen, Peter Kraft, Kenneth Krauter, Johanna Kuusisto, Markku Laakso, Jessica Lasky-Su, Wen-Jane Lee, James J. Lee, Daniel Levy, Liming Li, Kevin Li, Yuqing Li, Kuang Lin, Penelope A. Lind, Chunyu Liu, Donald M. Lloyd-Jones, Sharon M. Lutz, Jiantao Ma, Reedik Magi, Ani Manichaikul, Nicholas G. Martin, Ravi Mathur, Nana Matoba, Patrick F. McArdle, Matt McGue, Matthew B. McQueen, Sarah E. Medland, Andres Metspalu, Deborah A. Meyers, Iona Y. Millwood, Braxton D. Mitchell, Karen L. Mohlke, Matthew Moll, May E. Montasser, Alanna C. Morrison, Antonella Mulas, Jonas B. Nielsen, Kari E. North, Elizabeth C. Oelsner, Yukinori Okada, Valeria Orru, Nicholette D. Palmer, Teemu Palviainen, Anita Pandit, S. Lani Park, Ulrike Peters, Annette Peters, Patricia A. Peyser, Tinca J. C. Polderman, Nicholas Rafaels, Susan Redline, Robert M. Reed, Alex P. Reiner, John P. Rice, Stephen S. Rich, Nicole E. Richmond, Carol Roan, Jerome Rotter, Michael N. Rueschman, Valgerdur Runarsdottir, Nancy L. Saccone, David A. Schwartz, Aladdin H. Shadyab, Jingchunzi Shi, Suyash S. Shringarpure, Kamil Sicinski, Anne Heidi Skogholt, Jennifer A. Smith, Nicholas L. Smith, Nona Sotoodehnia, Michael C. Stallings, Hreinn Stefansson, Kari Stefansson, Jerry A. Stitzel, Xiao Sun, Moin Syed, Ruth Tal-Singer, Amy E. Taylor, Kent D. Taylor, Marilyn J. Telen, Khanh K. Thai, Hemant Tiwari, Constance Turman, Thorarinn Tyrfingsson, Tamara L. Wall, Robin G. Walters, David R. Weir, Scott T. Weiss, Wendy B. White, John B. Whitfield, Kerri L. Wiggins, Gonneke Willemsen, Cristen J. Willer, Bendik S. Winsvold, Huichun Xu, Lisa R. Yanek, Jie Yin, Kristin L. Young, Kendra A. Young, Bing Yu, Wei Zhao, Wei Zhou, Sebastian Zollner, Luisa Zuccolo, The Biobank Japan Project, Chiara Batini, Andrew W. Bergen, Laura J. Bierut, Sean P. David, Sarah A. Gagliano Taliun, Dana B. Hancock, Bibo Jiang, Marcus R. Munafo, Thorgeir E. Thorgeirsson, Dajiang J. Liu, Scott Vrieze

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature
Volume	612
Issue number	7941
Pages (from-to)	720-+
Number of pages	14
ISSN	0028-0836
DOIs	https://doi.org/10.1038/s41586-022-05477-4
Publication status	Published - 22 Dec 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

3111 Biomedicine
1184 Genetics, developmental biology, physiology

Access to Document

10.1038/s41586-022-05477-4

s41586-022-05477-4Final published version, 8.14 MBLicence: CC BY

Cite this

Saunders, G. R. B., Wang, X., Chen, F., Jang, S-K., Liu, M., Wang, C., Gao, S., Jiang, Y., Khunsriraksakul, C., Otto, J. M., Addison, C., Akiyama, M., Albert, C. M., Aliev, F., Alonso, A., Arnett, D. K., Ashley-Koch, A. E., Ashrani, A. A., Barnes, K. C., ... Vrieze, S. (2022). Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature, 612(7941), 720-+. https://doi.org/10.1038/s41586-022-05477-4

@article{e9423bdf9d6844c39d169ab7d57a7fa3,

title = "Genetic diversity fuels gene discovery for tobacco and alcohol use",

keywords = "Neurotrophic factors, Disease, Prediction, Protein, Model, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology",

author = "Saunders, {Gretchen R. B.} and Xingyan Wang and Fang Chen and Seon-Kyeong Jang and Mengzhen Liu and Chen Wang and Shuang Gao and Yu Jiang and Chachrit Khunsriraksakul and Otto, {Jacqueline M.} and Clifton Addison and Masato Akiyama and Albert, {Christine M.} and Fazil Aliev and Alvaro Alonso and Arnett, {Donna K.} and Ashley-Koch, {Allison E.} and Ashrani, {Aneel A.} and Barnes, {Kathleen C.} and Barr, {R. Graham} and Bartz, {Traci M.} and Becker, {Diane M.} and Bielak, {Lawrence F.} and Benjamin, {Emelia J.} and Bis, {Joshua C.} and Gyda Bjornsdottir and John Blangero and Bleecker, {Eugene R.} and Boardman, {Jason D.} and Eric Boerwinkle and Dorret Boomsma and Boorgula, {Meher Preethi} and Bowden, {Donald W.} and Brody, {Jennifer A.} and Cade, {Brian E.} and Daniel Chasman and Sameer Chavan and Chen, {Yii-Der Ida} and Zhengming Chen and Iona Cheng and Cho, {Michael H.} and Helene Choquet and Cole, {John W.} and Cornelis, {Marilyn C.} and Francesco Cucca and Curran, {Joanne E.} and {de Andrade}, Mariza and Dick, {Danielle M.} and Docherty, {Anna R.} and Ravindranath Duggirala and Eaton, {Charles B.} and Ehringer, {Marissa A.} and Tonu Esko and Faul, {Jessica D.} and Silva, {Lilian Fernandes} and Edoardo Fiorillo and Myriam Fornage and Barry Freedman and Gabrielsen, {Maiken E.} and Garrett, {Melanie E.} and Gharib, {Sina A.} and Christian Gieger and Nathan Gillespie and Glahn, {David C.} and Gordon, {Scott D.} and Gu, {Charles C.} and Dongfeng Gu and Gudbjartsson, {Daniel F.} and Xiuqing Guo and Jeffrey Haessler and Hall, {Michael E.} and Toomas Haller and Harris, {Kathleen Mullan} and Jiang He and Pamela Herd and Hewitt, {John K.} and Ian Hickie and Bertha Hidalgo and Hokanson, {John E.} and Christian Hopfer and JoukeJan Hottenga and Lifang Hou and Hongyan Huang and Yi-Jen Hung and Hunter, {David J.} and Kristian Hveem and Shih-Jen Hwang and Chii-Min Hwu and William Iacono and Irvin, {Marguerite R.} and Jee, {Yon Ho} and Johnson, {Eric O.} and Joo, {Yoonjung Y.} and Eric Jorgenson and Justice, {Anne E.} and Yoichiro Kamatani and Kaplan, {Robert C.} and Jaakko Kaprio and Kardia, {Sharon L. R.} and Keller, {Matthew C.} and Kelly, {Tanika N.} and Charles Kooperberg and Tellervo Korhonen and Peter Kraft and Kenneth Krauter and Johanna Kuusisto and Markku Laakso and Jessica Lasky-Su and Wen-Jane Lee and Lee, {James J.} and Daniel Levy and Liming Li and Kevin Li and Yuqing Li and Kuang Lin and Lind, {Penelope A.} and Chunyu Liu and Lloyd-Jones, {Donald M.} and Lutz, {Sharon M.} and Jiantao Ma and Reedik Magi and Ani Manichaikul and Martin, {Nicholas G.} and Ravi Mathur and Nana Matoba and McArdle, {Patrick F.} and Matt McGue and McQueen, {Matthew B.} and Medland, {Sarah E.} and Andres Metspalu and Meyers, {Deborah A.} and Millwood, {Iona Y.} and Mitchell, {Braxton D.} and Mohlke, {Karen L.} and Matthew Moll and Montasser, {May E.} and Morrison, {Alanna C.} and Antonella Mulas and Nielsen, {Jonas B.} and North, {Kari E.} and Oelsner, {Elizabeth C.} and Yukinori Okada and Valeria Orru and Palmer, {Nicholette D.} and Teemu Palviainen and Anita Pandit and Park, {S. Lani} and Ulrike Peters and Annette Peters and Peyser, {Patricia A.} and Polderman, {Tinca J. C.} and Nicholas Rafaels and Susan Redline and Reed, {Robert M.} and Reiner, {Alex P.} and Rice, {John P.} and Rich, {Stephen S.} and Richmond, {Nicole E.} and Carol Roan and Jerome Rotter and Rueschman, {Michael N.} and Valgerdur Runarsdottir and Saccone, {Nancy L.} and Schwartz, {David A.} and Shadyab, {Aladdin H.} and Jingchunzi Shi and Shringarpure, {Suyash S.} and Kamil Sicinski and Skogholt, {Anne Heidi} and Smith, {Jennifer A.} and Smith, {Nicholas L.} and Nona Sotoodehnia and Stallings, {Michael C.} and Hreinn Stefansson and Kari Stefansson and Stitzel, {Jerry A.} and Xiao Sun and Moin Syed and Ruth Tal-Singer and Taylor, {Amy E.} and Taylor, {Kent D.} and Telen, {Marilyn J.} and Thai, {Khanh K.} and Hemant Tiwari and Constance Turman and Thorarinn Tyrfingsson and Wall, {Tamara L.} and Walters, {Robin G.} and Weir, {David R.} and Weiss, {Scott T.} and White, {Wendy B.} and Whitfield, {John B.} and Wiggins, {Kerri L.} and Gonneke Willemsen and Willer, {Cristen J.} and Winsvold, {Bendik S.} and Huichun Xu and Yanek, {Lisa R.} and Jie Yin and Young, {Kristin L.} and Young, {Kendra A.} and Bing Yu and Wei Zhao and Wei Zhou and Sebastian Zollner and Luisa Zuccolo and Project, {The Biobank Japan} and Chiara Batini and Bergen, {Andrew W.} and Bierut, {Laura J.} and David, {Sean P.} and Taliun, {Sarah A. Gagliano} and Hancock, {Dana B.} and Bibo Jiang and Munafo, {Marcus R.} and Thorgeirsson, {Thorgeir E.} and Liu, {Dajiang J.} and Scott Vrieze",

year = "2022",

month = dec,

day = "22",

doi = "10.1038/s41586-022-05477-4",

language = "English",

volume = "612",

pages = "720--+",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7941",

}

Saunders, GRB, Wang, X, Chen, F, Jang, S-K, Liu, M, Wang, C, Gao, S, Jiang, Y, Khunsriraksakul, C, Otto, JM, Addison, C, Akiyama, M, Albert, CM, Aliev, F, Alonso, A, Arnett, DK, Ashley-Koch, AE, Ashrani, AA, Barnes, KC, Barr, RG, Bartz, TM, Becker, DM, Bielak, LF, Benjamin, EJ, Bis, JC, Bjornsdottir, G, Blangero, J, Bleecker, ER, Boardman, JD, Boerwinkle, E, Boomsma, D, Boorgula, MP, Bowden, DW, Brody, JA, Cade, BE, Chasman, D, Chavan, S, Chen, Y-DI, Chen, Z, Cheng, I, Cho, MH, Choquet, H, Cole, JW, Cornelis, MC, Cucca, F, Curran, JE, de Andrade, M, Dick, DM, Docherty, AR, Duggirala, R, Eaton, CB, Ehringer, MA, Esko, T, Faul, JD, Silva, LF, Fiorillo, E, Fornage, M, Freedman, B, Gabrielsen, ME, Garrett, ME, Gharib, SA, Gieger, C, Gillespie, N, Glahn, DC, Gordon, SD, Gu, CC, Gu, D, Gudbjartsson, DF, Guo, X, Haessler, J, Hall, ME, Haller, T, Harris, KM, He, J, Herd, P, Hewitt, JK, Hickie, I, Hidalgo, B, Hokanson, JE, Hopfer, C, Hottenga, J, Hou, L, Huang, H, Hung, Y-J, Hunter, DJ, Hveem, K, Hwang, S-J, Hwu, C-M, Iacono, W, Irvin, MR, Jee, YH, Johnson, EO, Joo, YY, Jorgenson, E, Justice, AE, Kamatani, Y, Kaplan, RC, Kaprio, J, Kardia, SLR, Keller, MC, Kelly, TN, Kooperberg, C, Korhonen, T, Kraft, P, Krauter, K, Kuusisto, J, Laakso, M, Lasky-Su, J, Lee, W-J, Lee, JJ, Levy, D, Li, L, Li, K, Li, Y, Lin, K, Lind, PA, Liu, C, Lloyd-Jones, DM, Lutz, SM, Ma, J, Magi, R, Manichaikul, A, Martin, NG, Mathur, R, Matoba, N, McArdle, PF, McGue, M, McQueen, MB, Medland, SE, Metspalu, A, Meyers, DA, Millwood, IY, Mitchell, BD, Mohlke, KL, Moll, M, Montasser, ME, Morrison, AC, Mulas, A, Nielsen, JB, North, KE, Oelsner, EC, Okada, Y, Orru, V, Palmer, ND, Palviainen, T, Pandit, A, Park, SL, Peters, U, Peters, A, Peyser, PA, Polderman, TJC, Rafaels, N, Redline, S, Reed, RM, Reiner, AP, Rice, JP, Rich, SS, Richmond, NE, Roan, C, Rotter, J, Rueschman, MN, Runarsdottir, V, Saccone, NL, Schwartz, DA, Shadyab, AH, Shi, J, Shringarpure, SS, Sicinski, K, Skogholt, AH, Smith, JA, Smith, NL, Sotoodehnia, N, Stallings, MC, Stefansson, H, Stefansson, K, Stitzel, JA, Sun, X, Syed, M, Tal-Singer, R, Taylor, AE, Taylor, KD, Telen, MJ, Thai, KK, Tiwari, H, Turman, C, Tyrfingsson, T, Wall, TL, Walters, RG, Weir, DR, Weiss, ST, White, WB, Whitfield, JB, Wiggins, KL, Willemsen, G, Willer, CJ, Winsvold, BS, Xu, H, Yanek, LR, Yin, J, Young, KL, Young, KA, Yu, B, Zhao, W, Zhou, W, Zollner, S, Zuccolo, L, Project, TBJ, Batini, C, Bergen, AW, Bierut, LJ, David, SP, Taliun, SAG, Hancock, DB, Jiang, B, Munafo, MR, Thorgeirsson, TE, Liu, DJ & Vrieze, S 2022, 'Genetic diversity fuels gene discovery for tobacco and alcohol use', Nature, vol. 612, no. 7941, pp. 720-+. https://doi.org/10.1038/s41586-022-05477-4

TY - JOUR

T1 - Genetic diversity fuels gene discovery for tobacco and alcohol use

AU - Saunders, Gretchen R. B.

AU - Wang, Xingyan

AU - Chen, Fang

AU - Jang, Seon-Kyeong

AU - Liu, Mengzhen

AU - Wang, Chen

AU - Gao, Shuang

AU - Jiang, Yu

AU - Khunsriraksakul, Chachrit

AU - Otto, Jacqueline M.

AU - Addison, Clifton

AU - Akiyama, Masato

AU - Albert, Christine M.

AU - Aliev, Fazil

AU - Alonso, Alvaro

AU - Arnett, Donna K.

AU - Ashley-Koch, Allison E.

AU - Ashrani, Aneel A.

AU - Barnes, Kathleen C.

AU - Barr, R. Graham

AU - Bartz, Traci M.

AU - Becker, Diane M.

AU - Bielak, Lawrence F.

AU - Benjamin, Emelia J.

AU - Bis, Joshua C.

AU - Bjornsdottir, Gyda

AU - Blangero, John

AU - Bleecker, Eugene R.

AU - Boardman, Jason D.

AU - Boerwinkle, Eric

AU - Boomsma, Dorret

AU - Boorgula, Meher Preethi

AU - Bowden, Donald W.

AU - Brody, Jennifer A.

AU - Cade, Brian E.

AU - Chasman, Daniel

AU - Chavan, Sameer

AU - Chen, Yii-Der Ida

AU - Chen, Zhengming

AU - Cheng, Iona

AU - Cho, Michael H.

AU - Choquet, Helene

AU - Cole, John W.

AU - Cornelis, Marilyn C.

AU - Cucca, Francesco

AU - Curran, Joanne E.

AU - de Andrade, Mariza

AU - Dick, Danielle M.

AU - Docherty, Anna R.

AU - Duggirala, Ravindranath

AU - Eaton, Charles B.

AU - Ehringer, Marissa A.

AU - Esko, Tonu

AU - Faul, Jessica D.

AU - Silva, Lilian Fernandes

AU - Fiorillo, Edoardo

AU - Fornage, Myriam

AU - Freedman, Barry

AU - Gabrielsen, Maiken E.

AU - Garrett, Melanie E.

AU - Gharib, Sina A.

AU - Gieger, Christian

AU - Gillespie, Nathan

AU - Glahn, David C.

AU - Gordon, Scott D.

AU - Gu, Charles C.

AU - Gu, Dongfeng

AU - Gudbjartsson, Daniel F.

AU - Guo, Xiuqing

AU - Haessler, Jeffrey

AU - Hall, Michael E.

AU - Haller, Toomas

AU - Harris, Kathleen Mullan

AU - He, Jiang

AU - Herd, Pamela

AU - Hewitt, John K.

AU - Hickie, Ian

AU - Hidalgo, Bertha

AU - Hokanson, John E.

AU - Hopfer, Christian

AU - Hottenga, JoukeJan

AU - Hou, Lifang

AU - Huang, Hongyan

AU - Hung, Yi-Jen

AU - Hunter, David J.

AU - Hveem, Kristian

AU - Hwang, Shih-Jen

AU - Hwu, Chii-Min

AU - Iacono, William

AU - Irvin, Marguerite R.

AU - Jee, Yon Ho

AU - Johnson, Eric O.

AU - Joo, Yoonjung Y.

AU - Jorgenson, Eric

AU - Justice, Anne E.

AU - Kamatani, Yoichiro

AU - Kaplan, Robert C.

AU - Kaprio, Jaakko

AU - Kardia, Sharon L. R.

AU - Keller, Matthew C.

AU - Kelly, Tanika N.

AU - Kooperberg, Charles

AU - Korhonen, Tellervo

AU - Kraft, Peter

AU - Krauter, Kenneth

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lasky-Su, Jessica

AU - Lee, Wen-Jane

AU - Lee, James J.

AU - Levy, Daniel

AU - Li, Liming

AU - Li, Kevin

AU - Li, Yuqing

AU - Lin, Kuang

AU - Lind, Penelope A.

AU - Liu, Chunyu

AU - Lloyd-Jones, Donald M.

AU - Lutz, Sharon M.

AU - Ma, Jiantao

AU - Magi, Reedik

AU - Manichaikul, Ani

AU - Martin, Nicholas G.

AU - Mathur, Ravi

AU - Matoba, Nana

AU - McArdle, Patrick F.

AU - McGue, Matt

AU - McQueen, Matthew B.

AU - Medland, Sarah E.

AU - Metspalu, Andres

AU - Meyers, Deborah A.

AU - Millwood, Iona Y.

AU - Mitchell, Braxton D.

AU - Mohlke, Karen L.

AU - Moll, Matthew

AU - Montasser, May E.

AU - Morrison, Alanna C.

AU - Mulas, Antonella

AU - Nielsen, Jonas B.

AU - North, Kari E.

AU - Oelsner, Elizabeth C.

AU - Okada, Yukinori

AU - Orru, Valeria

AU - Palmer, Nicholette D.

AU - Palviainen, Teemu

AU - Pandit, Anita

AU - Park, S. Lani

AU - Peters, Ulrike

AU - Peters, Annette

AU - Peyser, Patricia A.

AU - Polderman, Tinca J. C.

AU - Rafaels, Nicholas

AU - Redline, Susan

AU - Reed, Robert M.

AU - Reiner, Alex P.

AU - Rice, John P.

AU - Rich, Stephen S.

AU - Richmond, Nicole E.

AU - Roan, Carol

AU - Rotter, Jerome

AU - Rueschman, Michael N.

AU - Runarsdottir, Valgerdur

AU - Saccone, Nancy L.

AU - Schwartz, David A.

AU - Shadyab, Aladdin H.

AU - Shi, Jingchunzi

AU - Shringarpure, Suyash S.

AU - Sicinski, Kamil

AU - Skogholt, Anne Heidi

AU - Smith, Jennifer A.

AU - Smith, Nicholas L.

AU - Sotoodehnia, Nona

AU - Stallings, Michael C.

AU - Stefansson, Hreinn

AU - Stefansson, Kari

AU - Stitzel, Jerry A.

AU - Sun, Xiao

AU - Syed, Moin

AU - Tal-Singer, Ruth

AU - Taylor, Amy E.

AU - Taylor, Kent D.

AU - Telen, Marilyn J.

AU - Thai, Khanh K.

AU - Tiwari, Hemant

AU - Turman, Constance

AU - Tyrfingsson, Thorarinn

AU - Wall, Tamara L.

AU - Walters, Robin G.

AU - Weir, David R.

AU - Weiss, Scott T.

AU - White, Wendy B.

AU - Whitfield, John B.

AU - Wiggins, Kerri L.

AU - Willemsen, Gonneke

AU - Willer, Cristen J.

AU - Winsvold, Bendik S.

AU - Xu, Huichun

AU - Yanek, Lisa R.

AU - Yin, Jie

AU - Young, Kristin L.

AU - Young, Kendra A.

AU - Yu, Bing

AU - Zhao, Wei

AU - Zhou, Wei

AU - Zollner, Sebastian

AU - Zuccolo, Luisa

AU - Project, The Biobank Japan

AU - Batini, Chiara

AU - Bergen, Andrew W.

AU - Bierut, Laura J.

AU - David, Sean P.

AU - Taliun, Sarah A. Gagliano

AU - Hancock, Dana B.

AU - Jiang, Bibo

AU - Munafo, Marcus R.

AU - Thorgeirsson, Thorgeir E.

AU - Liu, Dajiang J.

AU - Vrieze, Scott

PY - 2022/12/22

Y1 - 2022/12/22

KW - Neurotrophic factors

KW - Disease

KW - Prediction

KW - Protein

KW - Model

KW - 3111 Biomedicine

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1038/s41586-022-05477-4

DO - 10.1038/s41586-022-05477-4

M3 - Article

C2 - 36477530

VL - 612

SP - 720-+

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7941

ER -