Genetic support for the causal role of insulin in coronary heart disease

Emmi Tikkanen, Matti Pirinen, Antti-Pekka Sarin, Aki S. Havulinna, Satu Mannisto, Juha Saltevo, Marja-Liisa Lokki, Juha Sinisalo, Annamari Lundqvist, Antti Jula, Veikko Salomaa, Samuli Ripatti

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.
Original languageFinnish
JournalDiabetologia
Volume59
Issue number11
Pages (from-to)2369-2377
Number of pages9
ISSN1432-0428
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3142 Public health care science, environmental and occupational health
  • 3111 Biomedicine
  • 3121 Internal medicine

Cite this

Tikkanen, Emmi ; Pirinen, Matti ; Sarin, Antti-Pekka ; Havulinna, Aki S. ; Mannisto, Satu ; Saltevo, Juha ; Lokki, Marja-Liisa ; Sinisalo, Juha ; Lundqvist, Annamari ; Jula, Antti ; Salomaa, Veikko ; Ripatti, Samuli. / Genetic support for the causal role of insulin in coronary heart disease. In: Diabetologia. 2016 ; Vol. 59, No. 11. pp. 2369-2377.
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title = "Genetic support for the causal role of insulin in coronary heart disease",
abstract = "Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.",
keywords = "3142 Kansanterveystiede, ymp{\"a}rist{\"o} ja ty{\"o}terveys, 3111 Biol{\"a}{\"a}ketieteet, 3121 Sis{\"a}taudit",
author = "Emmi Tikkanen and Matti Pirinen and Antti-Pekka Sarin and Havulinna, {Aki S.} and Satu Mannisto and Juha Saltevo and Marja-Liisa Lokki and Juha Sinisalo and Annamari Lundqvist and Antti Jula and Veikko Salomaa and Samuli Ripatti",
year = "2016",
doi = "10.1007/s00125-016-4081-6",
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volume = "59",
pages = "2369--2377",
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Tikkanen, E, Pirinen, M, Sarin, A-P, Havulinna, AS, Mannisto, S, Saltevo, J, Lokki, M-L, Sinisalo, J, Lundqvist, A, Jula, A, Salomaa, V & Ripatti, S 2016, 'Genetic support for the causal role of insulin in coronary heart disease', Diabetologia, vol. 59, no. 11, pp. 2369-2377. https://doi.org/10.1007/s00125-016-4081-6

Genetic support for the causal role of insulin in coronary heart disease. / Tikkanen, Emmi; Pirinen, Matti; Sarin, Antti-Pekka; Havulinna, Aki S.; Mannisto, Satu; Saltevo, Juha; Lokki, Marja-Liisa; Sinisalo, Juha; Lundqvist, Annamari; Jula, Antti; Salomaa, Veikko; Ripatti, Samuli.

In: Diabetologia, Vol. 59, No. 11, 2016, p. 2369-2377.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Genetic support for the causal role of insulin in coronary heart disease

AU - Tikkanen, Emmi

AU - Pirinen, Matti

AU - Sarin, Antti-Pekka

AU - Havulinna, Aki S.

AU - Mannisto, Satu

AU - Saltevo, Juha

AU - Lokki, Marja-Liisa

AU - Sinisalo, Juha

AU - Lundqvist, Annamari

AU - Jula, Antti

AU - Salomaa, Veikko

AU - Ripatti, Samuli

PY - 2016

Y1 - 2016

N2 - Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.

AB - Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.

KW - 3142 Kansanterveystiede, ympäristö ja työterveys

KW - 3111 Biolääketieteet

KW - 3121 Sisätaudit

U2 - 10.1007/s00125-016-4081-6

DO - 10.1007/s00125-016-4081-6

M3 - Artikkeli

VL - 59

SP - 2369

EP - 2377

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 11

ER -