Genetic support for the causal role of insulin in coronary heart disease

Emmi Tikkanen, Matti Pirinen, Antti-Pekka Sarin, Aki S. Havulinna, Satu Mannisto, Juha Saltevo, Marja-Liisa Lokki, Juha Sinisalo, Annamari Lundqvist, Antti Jula, Veikko Salomaa, Samuli Ripatti

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables.
Original languageFinnish
JournalDiabetologia
Volume59
Issue number11
Pages (from-to)2369-2377
Number of pages9
ISSN1432-0428
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3142 Public health care science, environmental and occupational health
  • 3111 Biomedicine
  • 3121 General medicine, internal medicine and other clinical medicine

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