Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Tuomas O. Kilpelainen, M. Carola Zillikens, Alena Stancakova, Francis M. Finucane, Janina S. Ried, Claudia Langenberg, Weihua Zhang, Jacques S. Beckmann, Jian'an Luan, Liesbeth Vandenput, Unnur Styrkarsdottir, Yanhua Zhou, Albert Vernon Smith, Jing-Hua Zhao, Najaf Amin, Sailaja Vedantam, So-Youn Shin, Talin Haritunians, Mao Fu, Mary F. FeitosaMeena Kumari, Bjarni V. Halldorsson, Emmi Tikkanen, Massimo Mangino, Caroline Hayward, Ci Song, Alice M. Arnold, Yurii S. Aulchenko, Ben A. Oostra, Harry Campbell, L. Adrienne Cupples, Kathryn E. Davis, Angela Doering, Gudny Eiriksdottir, Karol Estrada, Jose Manuel Fernandez-Real, Melissa Garcia, Christian Gieger, Nicole L. Glazer, Candace Guiducci, Albert Hofman, Steve E. Humphries, Bo Isomaa, Leonie C. Jacobs, Antti Jula, David Karasik, Magnus K. Karlsson, Kay-Tee Khaw, Lauren J. Kim, Mika Kivimaeki, Norman Klopp, Brigitte Kuehnel, Johanna Kuusisto, Yongmei Liu, Osten Ljunggren, Mattias Lorentzon, Robert N. Luben, Barbara McKnight, Dan Mellstrom, Braxton D. Mitchell, Vincent Mooser, Jose Maria Moreno, Satu Mannisto, Jeffery R. O'Connell, Laura Pascoe, Leena Palotie, Belen Peral, Markus Perola, Bruce M. Psaty, Veikko Salomaa, David B. Savage, Robert K. Semple, Tatjana Skaric-Juric, Gunnar Sigurdsson, Kijoung S. Song, Timothy D. Spector, Ann-Christine Syvanen, Philippa J. Talmud, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Andre G. Uitterlinden, Cornelia M. van Duijn, Antonio Vidal-Puig, Sarah H. Wild, Alan F. Wright, Deborah J. Clegg, Eric Schadt, James F. Wilson, Igor Rudan, Samuli Ripatti, Ingrid B. Borecki, Alan R. Shuldiner, Erik Ingelsson, John-Olov Jansson, Robert C. Kaplan, Vilmundur Gudnason, Tamara B. Harris, Leif Groop, Douglas P. Kiel, Fernando Rivadeneira, Mark Walker, Ines Barroso, Peter Vollenweider, Gerard Waeber, John C. Chambers, Jaspal S. Kooner, Nicole Soranzo, Joel N. Hirschhorn, Kari Stefansson, H-Erich Wichmann, Claes Ohlsson, Stephen O'Rahilly, Nicholas J. Wareham, Elizabeth K. Speliotes, Caroline S. Fox, Markku Laakso, Ruth J. F. Loos

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature Genetics
Volume43
Issue number8
Pages (from-to)753-U58
Number of pages11
ISSN1061-4036
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • INSULIN-RECEPTOR SUBSTRATE-1
  • BODY-MASS INDEX
  • ADIPOCYTE DIFFERENTIATION
  • ADULT OBESITY
  • FTO GENE
  • LOCI
  • RESISTANCE
  • EXPRESSION
  • MIGRATION
  • 3111 Biomedicine

Cite this

Kilpelainen, T. O., Zillikens, M. C., Stancakova, A., Finucane, F. M., Ried, J. S., Langenberg, C., ... Loos, R. J. F. (2011). Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics, 43(8), 753-U58. https://doi.org/10.1038/ng.866
Kilpelainen, Tuomas O. ; Zillikens, M. Carola ; Stancakova, Alena ; Finucane, Francis M. ; Ried, Janina S. ; Langenberg, Claudia ; Zhang, Weihua ; Beckmann, Jacques S. ; Luan, Jian'an ; Vandenput, Liesbeth ; Styrkarsdottir, Unnur ; Zhou, Yanhua ; Smith, Albert Vernon ; Zhao, Jing-Hua ; Amin, Najaf ; Vedantam, Sailaja ; Shin, So-Youn ; Haritunians, Talin ; Fu, Mao ; Feitosa, Mary F. ; Kumari, Meena ; Halldorsson, Bjarni V. ; Tikkanen, Emmi ; Mangino, Massimo ; Hayward, Caroline ; Song, Ci ; Arnold, Alice M. ; Aulchenko, Yurii S. ; Oostra, Ben A. ; Campbell, Harry ; Cupples, L. Adrienne ; Davis, Kathryn E. ; Doering, Angela ; Eiriksdottir, Gudny ; Estrada, Karol ; Manuel Fernandez-Real, Jose ; Garcia, Melissa ; Gieger, Christian ; Glazer, Nicole L. ; Guiducci, Candace ; Hofman, Albert ; Humphries, Steve E. ; Isomaa, Bo ; Jacobs, Leonie C. ; Jula, Antti ; Karasik, David ; Karlsson, Magnus K. ; Khaw, Kay-Tee ; Kim, Lauren J. ; Kivimaeki, Mika ; Klopp, Norman ; Kuehnel, Brigitte ; Kuusisto, Johanna ; Liu, Yongmei ; Ljunggren, Osten ; Lorentzon, Mattias ; Luben, Robert N. ; McKnight, Barbara ; Mellstrom, Dan ; Mitchell, Braxton D. ; Mooser, Vincent ; Maria Moreno, Jose ; Mannisto, Satu ; O'Connell, Jeffery R. ; Pascoe, Laura ; Palotie, Leena ; Peral, Belen ; Perola, Markus ; Psaty, Bruce M. ; Salomaa, Veikko ; Savage, David B. ; Semple, Robert K. ; Skaric-Juric, Tatjana ; Sigurdsson, Gunnar ; Song, Kijoung S. ; Spector, Timothy D. ; Syvanen, Ann-Christine ; Talmud, Philippa J. ; Thorleifsson, Gudmar ; Thorsteinsdottir, Unnur ; Uitterlinden, Andre G. ; van Duijn, Cornelia M. ; Vidal-Puig, Antonio ; Wild, Sarah H. ; Wright, Alan F. ; Clegg, Deborah J. ; Schadt, Eric ; Wilson, James F. ; Rudan, Igor ; Ripatti, Samuli ; Borecki, Ingrid B. ; Shuldiner, Alan R. ; Ingelsson, Erik ; Jansson, John-Olov ; Kaplan, Robert C. ; Gudnason, Vilmundur ; Harris, Tamara B. ; Groop, Leif ; Kiel, Douglas P. ; Rivadeneira, Fernando ; Walker, Mark ; Barroso, Ines ; Vollenweider, Peter ; Waeber, Gerard ; Chambers, John C. ; Kooner, Jaspal S. ; Soranzo, Nicole ; Hirschhorn, Joel N. ; Stefansson, Kari ; Wichmann, H-Erich ; Ohlsson, Claes ; O'Rahilly, Stephen ; Wareham, Nicholas J. ; Speliotes, Elizabeth K. ; Fox, Caroline S. ; Laakso, Markku ; Loos, Ruth J. F. / Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. In: Nature Genetics. 2011 ; Vol. 43, No. 8. pp. 753-U58.
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title = "Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile",
keywords = "GENOME-WIDE ASSOCIATION, INSULIN-RECEPTOR SUBSTRATE-1, BODY-MASS INDEX, ADIPOCYTE DIFFERENTIATION, ADULT OBESITY, FTO GENE, LOCI, RESISTANCE, EXPRESSION, MIGRATION, 3111 Biomedicine",
author = "Kilpelainen, {Tuomas O.} and Zillikens, {M. Carola} and Alena Stancakova and Finucane, {Francis M.} and Ried, {Janina S.} and Claudia Langenberg and Weihua Zhang and Beckmann, {Jacques S.} and Jian'an Luan and Liesbeth Vandenput and Unnur Styrkarsdottir and Yanhua Zhou and Smith, {Albert Vernon} and Jing-Hua Zhao and Najaf Amin and Sailaja Vedantam and So-Youn Shin and Talin Haritunians and Mao Fu and Feitosa, {Mary F.} and Meena Kumari and Halldorsson, {Bjarni V.} and Emmi Tikkanen and Massimo Mangino and Caroline Hayward and Ci Song and Arnold, {Alice M.} and Aulchenko, {Yurii S.} and Oostra, {Ben A.} and Harry Campbell and Cupples, {L. Adrienne} and Davis, {Kathryn E.} and Angela Doering and Gudny Eiriksdottir and Karol Estrada and {Manuel Fernandez-Real}, Jose and Melissa Garcia and Christian Gieger and Glazer, {Nicole L.} and Candace Guiducci and Albert Hofman and Humphries, {Steve E.} and Bo Isomaa and Jacobs, {Leonie C.} and Antti Jula and David Karasik and Karlsson, {Magnus K.} and Kay-Tee Khaw and Kim, {Lauren J.} and Mika Kivimaeki and Norman Klopp and Brigitte Kuehnel and Johanna Kuusisto and Yongmei Liu and Osten Ljunggren and Mattias Lorentzon and Luben, {Robert N.} and Barbara McKnight and Dan Mellstrom and Mitchell, {Braxton D.} and Vincent Mooser and {Maria Moreno}, Jose and Satu Mannisto and O'Connell, {Jeffery R.} and Laura Pascoe and Leena Palotie and Belen Peral and Markus Perola and Psaty, {Bruce M.} and Veikko Salomaa and Savage, {David B.} and Semple, {Robert K.} and Tatjana Skaric-Juric and Gunnar Sigurdsson and Song, {Kijoung S.} and Spector, {Timothy D.} and Ann-Christine Syvanen and Talmud, {Philippa J.} and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Uitterlinden, {Andre G.} and {van Duijn}, {Cornelia M.} and Antonio Vidal-Puig and Wild, {Sarah H.} and Wright, {Alan F.} and Clegg, {Deborah J.} and Eric Schadt and Wilson, {James F.} and Igor Rudan and Samuli Ripatti and Borecki, {Ingrid B.} and Shuldiner, {Alan R.} and Erik Ingelsson and John-Olov Jansson and Kaplan, {Robert C.} and Vilmundur Gudnason and Harris, {Tamara B.} and Leif Groop and Kiel, {Douglas P.} and Fernando Rivadeneira and Mark Walker and Ines Barroso and Peter Vollenweider and Gerard Waeber and Chambers, {John C.} and Kooner, {Jaspal S.} and Nicole Soranzo and Hirschhorn, {Joel N.} and Kari Stefansson and H-Erich Wichmann and Claes Ohlsson and Stephen O'Rahilly and Wareham, {Nicholas J.} and Speliotes, {Elizabeth K.} and Fox, {Caroline S.} and Markku Laakso and Loos, {Ruth J. F.}",
year = "2011",
doi = "10.1038/ng.866",
language = "English",
volume = "43",
pages = "753--U58",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",

}

Kilpelainen, TO, Zillikens, MC, Stancakova, A, Finucane, FM, Ried, JS, Langenberg, C, Zhang, W, Beckmann, JS, Luan, J, Vandenput, L, Styrkarsdottir, U, Zhou, Y, Smith, AV, Zhao, J-H, Amin, N, Vedantam, S, Shin, S-Y, Haritunians, T, Fu, M, Feitosa, MF, Kumari, M, Halldorsson, BV, Tikkanen, E, Mangino, M, Hayward, C, Song, C, Arnold, AM, Aulchenko, YS, Oostra, BA, Campbell, H, Cupples, LA, Davis, KE, Doering, A, Eiriksdottir, G, Estrada, K, Manuel Fernandez-Real, J, Garcia, M, Gieger, C, Glazer, NL, Guiducci, C, Hofman, A, Humphries, SE, Isomaa, B, Jacobs, LC, Jula, A, Karasik, D, Karlsson, MK, Khaw, K-T, Kim, LJ, Kivimaeki, M, Klopp, N, Kuehnel, B, Kuusisto, J, Liu, Y, Ljunggren, O, Lorentzon, M, Luben, RN, McKnight, B, Mellstrom, D, Mitchell, BD, Mooser, V, Maria Moreno, J, Mannisto, S, O'Connell, JR, Pascoe, L, Palotie, L, Peral, B, Perola, M, Psaty, BM, Salomaa, V, Savage, DB, Semple, RK, Skaric-Juric, T, Sigurdsson, G, Song, KS, Spector, TD, Syvanen, A-C, Talmud, PJ, Thorleifsson, G, Thorsteinsdottir, U, Uitterlinden, AG, van Duijn, CM, Vidal-Puig, A, Wild, SH, Wright, AF, Clegg, DJ, Schadt, E, Wilson, JF, Rudan, I, Ripatti, S, Borecki, IB, Shuldiner, AR, Ingelsson, E, Jansson, J-O, Kaplan, RC, Gudnason, V, Harris, TB, Groop, L, Kiel, DP, Rivadeneira, F, Walker, M, Barroso, I, Vollenweider, P, Waeber, G, Chambers, JC, Kooner, JS, Soranzo, N, Hirschhorn, JN, Stefansson, K, Wichmann, H-E, Ohlsson, C, O'Rahilly, S, Wareham, NJ, Speliotes, EK, Fox, CS, Laakso, M & Loos, RJF 2011, 'Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile', Nature Genetics, vol. 43, no. 8, pp. 753-U58. https://doi.org/10.1038/ng.866

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. / Kilpelainen, Tuomas O.; Zillikens, M. Carola; Stancakova, Alena; Finucane, Francis M.; Ried, Janina S.; Langenberg, Claudia; Zhang, Weihua; Beckmann, Jacques S.; Luan, Jian'an; Vandenput, Liesbeth; Styrkarsdottir, Unnur; Zhou, Yanhua; Smith, Albert Vernon; Zhao, Jing-Hua; Amin, Najaf; Vedantam, Sailaja; Shin, So-Youn; Haritunians, Talin; Fu, Mao; Feitosa, Mary F.; Kumari, Meena; Halldorsson, Bjarni V.; Tikkanen, Emmi; Mangino, Massimo; Hayward, Caroline; Song, Ci; Arnold, Alice M.; Aulchenko, Yurii S.; Oostra, Ben A.; Campbell, Harry; Cupples, L. Adrienne; Davis, Kathryn E.; Doering, Angela; Eiriksdottir, Gudny; Estrada, Karol; Manuel Fernandez-Real, Jose; Garcia, Melissa; Gieger, Christian; Glazer, Nicole L.; Guiducci, Candace; Hofman, Albert; Humphries, Steve E.; Isomaa, Bo; Jacobs, Leonie C.; Jula, Antti; Karasik, David; Karlsson, Magnus K.; Khaw, Kay-Tee; Kim, Lauren J.; Kivimaeki, Mika; Klopp, Norman; Kuehnel, Brigitte; Kuusisto, Johanna; Liu, Yongmei; Ljunggren, Osten; Lorentzon, Mattias; Luben, Robert N.; McKnight, Barbara; Mellstrom, Dan; Mitchell, Braxton D.; Mooser, Vincent; Maria Moreno, Jose; Mannisto, Satu; O'Connell, Jeffery R.; Pascoe, Laura; Palotie, Leena; Peral, Belen; Perola, Markus; Psaty, Bruce M.; Salomaa, Veikko; Savage, David B.; Semple, Robert K.; Skaric-Juric, Tatjana; Sigurdsson, Gunnar; Song, Kijoung S.; Spector, Timothy D.; Syvanen, Ann-Christine; Talmud, Philippa J.; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Uitterlinden, Andre G.; van Duijn, Cornelia M.; Vidal-Puig, Antonio; Wild, Sarah H.; Wright, Alan F.; Clegg, Deborah J.; Schadt, Eric; Wilson, James F.; Rudan, Igor; Ripatti, Samuli; Borecki, Ingrid B.; Shuldiner, Alan R.; Ingelsson, Erik; Jansson, John-Olov; Kaplan, Robert C.; Gudnason, Vilmundur; Harris, Tamara B.; Groop, Leif; Kiel, Douglas P.; Rivadeneira, Fernando; Walker, Mark; Barroso, Ines; Vollenweider, Peter; Waeber, Gerard; Chambers, John C.; Kooner, Jaspal S.; Soranzo, Nicole; Hirschhorn, Joel N.; Stefansson, Kari; Wichmann, H-Erich; Ohlsson, Claes; O'Rahilly, Stephen; Wareham, Nicholas J.; Speliotes, Elizabeth K.; Fox, Caroline S.; Laakso, Markku; Loos, Ruth J. F.

In: Nature Genetics, Vol. 43, No. 8, 2011, p. 753-U58.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

AU - Kilpelainen, Tuomas O.

AU - Zillikens, M. Carola

AU - Stancakova, Alena

AU - Finucane, Francis M.

AU - Ried, Janina S.

AU - Langenberg, Claudia

AU - Zhang, Weihua

AU - Beckmann, Jacques S.

AU - Luan, Jian'an

AU - Vandenput, Liesbeth

AU - Styrkarsdottir, Unnur

AU - Zhou, Yanhua

AU - Smith, Albert Vernon

AU - Zhao, Jing-Hua

AU - Amin, Najaf

AU - Vedantam, Sailaja

AU - Shin, So-Youn

AU - Haritunians, Talin

AU - Fu, Mao

AU - Feitosa, Mary F.

AU - Kumari, Meena

AU - Halldorsson, Bjarni V.

AU - Tikkanen, Emmi

AU - Mangino, Massimo

AU - Hayward, Caroline

AU - Song, Ci

AU - Arnold, Alice M.

AU - Aulchenko, Yurii S.

AU - Oostra, Ben A.

AU - Campbell, Harry

AU - Cupples, L. Adrienne

AU - Davis, Kathryn E.

AU - Doering, Angela

AU - Eiriksdottir, Gudny

AU - Estrada, Karol

AU - Manuel Fernandez-Real, Jose

AU - Garcia, Melissa

AU - Gieger, Christian

AU - Glazer, Nicole L.

AU - Guiducci, Candace

AU - Hofman, Albert

AU - Humphries, Steve E.

AU - Isomaa, Bo

AU - Jacobs, Leonie C.

AU - Jula, Antti

AU - Karasik, David

AU - Karlsson, Magnus K.

AU - Khaw, Kay-Tee

AU - Kim, Lauren J.

AU - Kivimaeki, Mika

AU - Klopp, Norman

AU - Kuehnel, Brigitte

AU - Kuusisto, Johanna

AU - Liu, Yongmei

AU - Ljunggren, Osten

AU - Lorentzon, Mattias

AU - Luben, Robert N.

AU - McKnight, Barbara

AU - Mellstrom, Dan

AU - Mitchell, Braxton D.

AU - Mooser, Vincent

AU - Maria Moreno, Jose

AU - Mannisto, Satu

AU - O'Connell, Jeffery R.

AU - Pascoe, Laura

AU - Palotie, Leena

AU - Peral, Belen

AU - Perola, Markus

AU - Psaty, Bruce M.

AU - Salomaa, Veikko

AU - Savage, David B.

AU - Semple, Robert K.

AU - Skaric-Juric, Tatjana

AU - Sigurdsson, Gunnar

AU - Song, Kijoung S.

AU - Spector, Timothy D.

AU - Syvanen, Ann-Christine

AU - Talmud, Philippa J.

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Uitterlinden, Andre G.

AU - van Duijn, Cornelia M.

AU - Vidal-Puig, Antonio

AU - Wild, Sarah H.

AU - Wright, Alan F.

AU - Clegg, Deborah J.

AU - Schadt, Eric

AU - Wilson, James F.

AU - Rudan, Igor

AU - Ripatti, Samuli

AU - Borecki, Ingrid B.

AU - Shuldiner, Alan R.

AU - Ingelsson, Erik

AU - Jansson, John-Olov

AU - Kaplan, Robert C.

AU - Gudnason, Vilmundur

AU - Harris, Tamara B.

AU - Groop, Leif

AU - Kiel, Douglas P.

AU - Rivadeneira, Fernando

AU - Walker, Mark

AU - Barroso, Ines

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Chambers, John C.

AU - Kooner, Jaspal S.

AU - Soranzo, Nicole

AU - Hirschhorn, Joel N.

AU - Stefansson, Kari

AU - Wichmann, H-Erich

AU - Ohlsson, Claes

AU - O'Rahilly, Stephen

AU - Wareham, Nicholas J.

AU - Speliotes, Elizabeth K.

AU - Fox, Caroline S.

AU - Laakso, Markku

AU - Loos, Ruth J. F.

PY - 2011

Y1 - 2011

KW - GENOME-WIDE ASSOCIATION

KW - INSULIN-RECEPTOR SUBSTRATE-1

KW - BODY-MASS INDEX

KW - ADIPOCYTE DIFFERENTIATION

KW - ADULT OBESITY

KW - FTO GENE

KW - LOCI

KW - RESISTANCE

KW - EXPRESSION

KW - MIGRATION

KW - 3111 Biomedicine

U2 - 10.1038/ng.866

DO - 10.1038/ng.866

M3 - Article

VL - 43

SP - 753-U58

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -

Kilpelainen TO, Zillikens MC, Stancakova A, Finucane FM, Ried JS, Langenberg C et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics. 2011;43(8):753-U58. https://doi.org/10.1038/ng.866