Genome-wide association analysis identifies six new loci associated with forced vital capacity

Daan W. Loth; Maria Soler Artigas; Sina A. Gharib; Louise V. Wain; Nora Franceschini; Beate Koch; Tess D. Pottinger; Albert Vernon Smith; Qing Duan; Chris Oldmeadow; Mi Kyeong Lee; David P. Strachan; Alan L. James; Jennifer E. Huffman; Veronique Vitart; Adaikalavan Ramasamy; Nicholas J. Wareham; Jaakko Kaprio; Xin-Qun Wang; Holly Trochet; Mika Kaonen; Claudia Flexeder; Eva Albrecht; Lorna M. Lopez; Kim de Jong; Bharat Thyagarajan; Alexessander Couto Alves; Stefan Enroth; Ernst Omenaas; Peter K. Joshi; Tove Fall; Ana Vinuela; Lenore J. Launer; Laura R. Loehr; Myriam Fornage; Guo Li; Jemma B. Wik; Wenbo Tang; Ani Manichaikul; Lies Lahousse; Tamara B. Harris; Kari E. North; Alicja R. Rudnicka; Jennie Hui; Xiangjun Gu; Thomas Lumley; Alan F. Wright; Nicholas D. Hastie; Susan Campbell; Rajesh Kumar; Isabelle Pin; Robert A. Scott; Kirsi H. Pietilainen; Ida Surakka; Yongmei Liu; Elizabeth G. Holliday; Holger Schulz; Joachim Heinrich; Gail Davies; Judith M. Vonk; Mary Wojczynski; Anneli Pouta; Asa Johansson; Sarah H. Wild; Erik Ingelsson; Fernando Rivadeneira; Henry Voezke; Pirro G. Hysi; Gudny Eiriksdottir; Alanna C. Morrison; Jerome I. Rotter; Wei Gao; Dirkje S. Postma; Wendy B. White; Stephen S. Rich; Albert Hofman; Thor Aspelund; David Couper; Lewis J. Smith; Bruce M. Psaty; Kurt Lohman; Esteban G. Burchard; Andre G. Uitterlinden; Melissa Garcia; Bonnie R. Joubert; Wendy L. McArdle; A. Bill Musk; Nadia Hansel; Susan R. Heckbert; Lina Zgaga; Joyce B. J. van Meurs; Pau Navarro; Igor Rudan; Yeon-Mok Oh; Susan Redline; Deborah L. Jarvis; Jing Hua Zhao; Taina Rantanen; George T. O'Connor; Samuli Ripatti; Rodney J. Scott; Stefan Karrasch; Harald Grallert; Nathan C. Gaddis; John M. Starr; Cisca Wijmenga; Ryan L. Minster; David J. Lederer; Juha Pekkanen; Ulf Gyllensten; Harry Campbe; Andrew P. Morris; Sven Glaeser; Christopher J. Hammond; Kristin M. Burkart; John Beilby; Stephen B. Kritchevsky; Vilrnundur Gucinason; Dana B. Hancock; Dale Williams; Ozren Polasek; Tatijana Zemunik; Ivana Kolcic; Marcy F. Petrini; Matthias Wjst; Woo Jin Kim; David J. Porteous; Generation Scotland; Blair H. Smith; Anne Villanen; Markku Heliovaara; John R. Attia; Ian Sayers; Regina Hampel; Christian Gieger; Ian J. Deary; H. Marike Boezen; Anne Newman; Marjo-Riitta Jarvelin; James F. Wilson; Lars Lind; Bruno H. Stricker; Alexander Teumer; Timothy D. Spector; Erik Melen; Marjolein J. Peters; Leslie A. Lange; R. Graham Barr; Ken R. Bracke; Fien M. Verhamme; Joohon Sung; Pieter S. Hiemstra; Patricia A. Cassano; Akshay Sood; Caroline Hayward; Josee Dupuis; Ian P. Hall; Guy G. Brusselle; Martin D. Tobin; Stephanie J. London

doi:10.1038/ng.3011

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Daan W. Loth
, Maria Soler Artigas
, Sina A. Gharib
, Louise V. Wain
, Nora Franceschini
, Beate Koch
, Tess D. Pottinger
, Albert Vernon Smith
, Qing Duan
, Chris Oldmeadow
, Mi Kyeong Lee
, David P. Strachan
, Alan L. James
, Jennifer E. Huffman
, Veronique Vitart
, Adaikalavan Ramasamy
, Nicholas J. Wareham
, Jaakko Kaprio
, Xin-Qun Wang
, Holly Trochet

Mika Kaonen, Claudia Flexeder, Eva Albrecht, Lorna M. Lopez, Kim de Jong, Bharat Thyagarajan, Alexessander Couto Alves, Stefan Enroth, Ernst Omenaas, Peter K. Joshi, Tove Fall, Ana Vinuela, Lenore J. Launer, Laura R. Loehr, Myriam Fornage, Guo Li, Jemma B. Wik, Wenbo Tang, Ani Manichaikul, Lies Lahousse, Tamara B. Harris, Kari E. North, Alicja R. Rudnicka, Jennie Hui, Xiangjun Gu, Thomas Lumley, Alan F. Wright, Nicholas D. Hastie, Susan Campbell, Rajesh Kumar, Isabelle Pin, Robert A. Scott, Kirsi H. Pietilainen, Ida Surakka, Yongmei Liu, Elizabeth G. Holliday, Holger Schulz, Joachim Heinrich, Gail Davies, Judith M. Vonk, Mary Wojczynski, Anneli Pouta, Asa Johansson, Sarah H. Wild, Erik Ingelsson, Fernando Rivadeneira, Henry Voezke, Pirro G. Hysi, Gudny Eiriksdottir, Alanna C. Morrison, Jerome I. Rotter, Wei Gao, Dirkje S. Postma, Wendy B. White, Stephen S. Rich, Albert Hofman, Thor Aspelund, David Couper, Lewis J. Smith, Bruce M. Psaty, Kurt Lohman, Esteban G. Burchard, Andre G. Uitterlinden, Melissa Garcia, Bonnie R. Joubert, Wendy L. McArdle, A. Bill Musk, Nadia Hansel, Susan R. Heckbert, Lina Zgaga, Joyce B. J. van Meurs, Pau Navarro, Igor Rudan, Yeon-Mok Oh, Susan Redline, Deborah L. Jarvis, Jing Hua Zhao, Taina Rantanen, George T. O'Connor, Samuli Ripatti, Rodney J. Scott, Stefan Karrasch, Harald Grallert, Nathan C. Gaddis, John M. Starr, Cisca Wijmenga, Ryan L. Minster, David J. Lederer, Juha Pekkanen, Ulf Gyllensten, Harry Campbe, Andrew P. Morris, Sven Glaeser, Christopher J. Hammond, Kristin M. Burkart, John Beilby, Stephen B. Kritchevsky, Vilrnundur Gucinason, Dana B. Hancock, Dale Williams, Ozren Polasek, Tatijana Zemunik, Ivana Kolcic, Marcy F. Petrini, Matthias Wjst, Woo Jin Kim, David J. Porteous, Generation Scotland, Blair H. Smith, Anne Villanen, Markku Heliovaara, John R. Attia, Ian Sayers, Regina Hampel, Christian Gieger, Ian J. Deary, H. Marike Boezen, Anne Newman, Marjo-Riitta Jarvelin, James F. Wilson, Lars Lind, Bruno H. Stricker, Alexander Teumer, Timothy D. Spector, Erik Melen, Marjolein J. Peters, Leslie A. Lange, R. Graham Barr, Ken R. Bracke, Fien M. Verhamme, Joohon Sung, Pieter S. Hiemstra, Patricia A. Cassano, Akshay Sood, Caroline Hayward, Josee Dupuis, Ian P. Hall, Guy G. Brusselle, Martin D. Tobin, Stephanie J. London

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature Genetics
Volume	46
Issue number	7
Pages (from-to)	669-677
Number of pages	9
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.3011
Publication status	Published - Jul 2014
MoE publication type	A1 Journal article-refereed

Fields of Science

IDIOPATHIC PULMONARY-FIBROSIS
LUNG-FUNCTION
GENE-EXPRESSION
HEALTHY TWIN
HERITABILITY
DISEASE
TRAITS
CELLS
MORTALITY
FAMILY
3111 Biomedicine

Access to Document

10.1038/ng.3011

Cite this

Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C., Lee, M. K., Strachan, D. P., James, A. L., Huffman, J. E., Vitart, V., Ramasamy, A., Wareham, N. J., Kaprio, J., Wang, X.-Q., ... London, S. J. (2014). Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature Genetics, 46(7), 669-677. https://doi.org/10.1038/ng.3011

@article{8304c0c5794e4bf49a0ecfaf8b2bfac0,

title = "Genome-wide association analysis identifies six new loci associated with forced vital capacity",

keywords = "IDIOPATHIC PULMONARY-FIBROSIS, LUNG-FUNCTION, GENE-EXPRESSION, HEALTHY TWIN, HERITABILITY, DISEASE, TRAITS, CELLS, MORTALITY, FAMILY, 3111 Biomedicine",

author = "Loth, \{Daan W.\} and Artigas, \{Maria Soler\} and Gharib, \{Sina A.\} and Wain, \{Louise V.\} and Nora Franceschini and Beate Koch and Pottinger, \{Tess D.\} and Smith, \{Albert Vernon\} and Qing Duan and Chris Oldmeadow and Lee, \{Mi Kyeong\} and Strachan, \{David P.\} and James, \{Alan L.\} and Huffman, \{Jennifer E.\} and Veronique Vitart and Adaikalavan Ramasamy and Wareham, \{Nicholas J.\} and Jaakko Kaprio and Xin-Qun Wang and Holly Trochet and Mika Kaonen and Claudia Flexeder and Eva Albrecht and Lopez, \{Lorna M.\} and \{de Jong\}, Kim and Bharat Thyagarajan and Alves, \{Alexessander Couto\} and Stefan Enroth and Ernst Omenaas and Joshi, \{Peter K.\} and Tove Fall and Ana Vinuela and Launer, \{Lenore J.\} and Loehr, \{Laura R.\} and Myriam Fornage and Guo Li and Wik, \{Jemma B.\} and Wenbo Tang and Ani Manichaikul and Lies Lahousse and Harris, \{Tamara B.\} and North, \{Kari E.\} and Rudnicka, \{Alicja R.\} and Jennie Hui and Xiangjun Gu and Thomas Lumley and Wright, \{Alan F.\} and Hastie, \{Nicholas D.\} and Susan Campbell and Rajesh Kumar and Isabelle Pin and Scott, \{Robert A.\} and Pietilainen, \{Kirsi H.\} and Ida Surakka and Yongmei Liu and Holliday, \{Elizabeth G.\} and Holger Schulz and Joachim Heinrich and Gail Davies and Vonk, \{Judith M.\} and Mary Wojczynski and Anneli Pouta and Asa Johansson and Wild, \{Sarah H.\} and Erik Ingelsson and Fernando Rivadeneira and Henry Voezke and Hysi, \{Pirro G.\} and Gudny Eiriksdottir and Morrison, \{Alanna C.\} and Rotter, \{Jerome I.\} and Wei Gao and Postma, \{Dirkje S.\} and White, \{Wendy B.\} and Rich, \{Stephen S.\} and Albert Hofman and Thor Aspelund and David Couper and Smith, \{Lewis J.\} and Psaty, \{Bruce M.\} and Kurt Lohman and Burchard, \{Esteban G.\} and Uitterlinden, \{Andre G.\} and Melissa Garcia and Joubert, \{Bonnie R.\} and McArdle, \{Wendy L.\} and Musk, \{A. Bill\} and Nadia Hansel and Heckbert, \{Susan R.\} and Lina Zgaga and \{van Meurs\}, \{Joyce B. J.\} and Pau Navarro and Igor Rudan and Yeon-Mok Oh and Susan Redline and Jarvis, \{Deborah L.\} and Zhao, \{Jing Hua\} and Taina Rantanen and O'Connor, \{George T.\} and Samuli Ripatti and Scott, \{Rodney J.\} and Stefan Karrasch and Harald Grallert and Gaddis, \{Nathan C.\} and Starr, \{John M.\} and Cisca Wijmenga and Minster, \{Ryan L.\} and Lederer, \{David J.\} and Juha Pekkanen and Ulf Gyllensten and Harry Campbe and Morris, \{Andrew P.\} and Sven Glaeser and Hammond, \{Christopher J.\} and Burkart, \{Kristin M.\} and John Beilby and Kritchevsky, \{Stephen B.\} and Vilrnundur Gucinason and Hancock, \{Dana B.\} and Dale Williams and Ozren Polasek and Tatijana Zemunik and Ivana Kolcic and Petrini, \{Marcy F.\} and Matthias Wjst and Kim, \{Woo Jin\} and Porteous, \{David J.\} and Generation Scotland and Smith, \{Blair H.\} and Anne Villanen and Markku Heliovaara and Attia, \{John R.\} and Ian Sayers and Regina Hampel and Christian Gieger and Deary, \{Ian J.\} and Boezen, \{H. Marike\} and Anne Newman and Marjo-Riitta Jarvelin and Wilson, \{James F.\} and Lars Lind and Stricker, \{Bruno H.\} and Alexander Teumer and Spector, \{Timothy D.\} and Erik Melen and Peters, \{Marjolein J.\} and Lange, \{Leslie A.\} and Barr, \{R. Graham\} and Bracke, \{Ken R.\} and Verhamme, \{Fien M.\} and Joohon Sung and Hiemstra, \{Pieter S.\} and Cassano, \{Patricia A.\} and Akshay Sood and Caroline Hayward and Josee Dupuis and Hall, \{Ian P.\} and Brusselle, \{Guy G.\} and Tobin, \{Martin D.\} and London, \{Stephanie J.\}",

year = "2014",

month = jul,

doi = "10.1038/ng.3011",

language = "English",

volume = "46",

pages = "669--677",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research ",

number = "7",

}

Loth, DW, Artigas, MS, Gharib, SA, Wain, LV, Franceschini, N, Koch, B, Pottinger, TD, Smith, AV, Duan, Q, Oldmeadow, C, Lee, MK, Strachan, DP, James, AL, Huffman, JE, Vitart, V, Ramasamy, A, Wareham, NJ, Kaprio, J, Wang, X-Q, Trochet, H, Kaonen, M, Flexeder, C, Albrecht, E, Lopez, LM, de Jong, K, Thyagarajan, B, Alves, AC, Enroth, S, Omenaas, E, Joshi, PK, Fall, T, Vinuela, A, Launer, LJ, Loehr, LR, Fornage, M, Li, G, Wik, JB, Tang, W, Manichaikul, A, Lahousse, L, Harris, TB, North, KE, Rudnicka, AR, Hui, J, Gu, X, Lumley, T, Wright, AF, Hastie, ND, Campbell, S, Kumar, R, Pin, I, Scott, RA, Pietilainen, KH, Surakka, I, Liu, Y, Holliday, EG, Schulz, H, Heinrich, J, Davies, G, Vonk, JM, Wojczynski, M, Pouta, A, Johansson, A, Wild, SH, Ingelsson, E, Rivadeneira, F, Voezke, H, Hysi, PG, Eiriksdottir, G, Morrison, AC, Rotter, JI, Gao, W, Postma, DS, White, WB, Rich, SS, Hofman, A, Aspelund, T, Couper, D, Smith, LJ, Psaty, BM, Lohman, K, Burchard, EG, Uitterlinden, AG, Garcia, M, Joubert, BR, McArdle, WL, Musk, AB, Hansel, N, Heckbert, SR, Zgaga, L, van Meurs, JBJ, Navarro, P, Rudan, I, Oh, Y-M, Redline, S, Jarvis, DL, Zhao, JH, Rantanen, T, O'Connor, GT, Ripatti, S, Scott, RJ, Karrasch, S, Grallert, H, Gaddis, NC, Starr, JM, Wijmenga, C, Minster, RL, Lederer, DJ, Pekkanen, J, Gyllensten, U, Campbe, H, Morris, AP, Glaeser, S, Hammond, CJ, Burkart, KM, Beilby, J, Kritchevsky, SB, Gucinason, V, Hancock, DB, Williams, D, Polasek, O, Zemunik, T, Kolcic, I, Petrini, MF, Wjst, M, Kim, WJ, Porteous, DJ, Scotland, G, Smith, BH, Villanen, A, Heliovaara, M, Attia, JR, Sayers, I, Hampel, R, Gieger, C, Deary, IJ, Boezen, HM, Newman, A, Jarvelin, M-R, Wilson, JF, Lind, L, Stricker, BH, Teumer, A, Spector, TD, Melen, E, Peters, MJ, Lange, LA, Barr, RG, Bracke, KR, Verhamme, FM, Sung, J, Hiemstra, PS, Cassano, PA, Sood, A, Hayward, C, Dupuis, J, Hall, IP, Brusselle, GG, Tobin, MD & London, SJ 2014, 'Genome-wide association analysis identifies six new loci associated with forced vital capacity', Nature Genetics, vol. 46, no. 7, pp. 669-677. https://doi.org/10.1038/ng.3011

TY - JOUR

T1 - Genome-wide association analysis identifies six new loci associated with forced vital capacity

AU - Loth, Daan W.

AU - Artigas, Maria Soler

AU - Gharib, Sina A.

AU - Wain, Louise V.

AU - Franceschini, Nora

AU - Koch, Beate

AU - Pottinger, Tess D.

AU - Smith, Albert Vernon

AU - Duan, Qing

AU - Oldmeadow, Chris

AU - Lee, Mi Kyeong

AU - Strachan, David P.

AU - James, Alan L.

AU - Huffman, Jennifer E.

AU - Vitart, Veronique

AU - Ramasamy, Adaikalavan

AU - Wareham, Nicholas J.

AU - Kaprio, Jaakko

AU - Wang, Xin-Qun

AU - Trochet, Holly

AU - Kaonen, Mika

AU - Flexeder, Claudia

AU - Albrecht, Eva

AU - Lopez, Lorna M.

AU - de Jong, Kim

AU - Thyagarajan, Bharat

AU - Alves, Alexessander Couto

AU - Enroth, Stefan

AU - Omenaas, Ernst

AU - Joshi, Peter K.

AU - Fall, Tove

AU - Vinuela, Ana

AU - Launer, Lenore J.

AU - Loehr, Laura R.

AU - Fornage, Myriam

AU - Li, Guo

AU - Wik, Jemma B.

AU - Tang, Wenbo

AU - Manichaikul, Ani

AU - Lahousse, Lies

AU - Harris, Tamara B.

AU - North, Kari E.

AU - Rudnicka, Alicja R.

AU - Hui, Jennie

AU - Gu, Xiangjun

AU - Lumley, Thomas

AU - Wright, Alan F.

AU - Hastie, Nicholas D.

AU - Campbell, Susan

AU - Kumar, Rajesh

AU - Pin, Isabelle

AU - Scott, Robert A.

AU - Pietilainen, Kirsi H.

AU - Surakka, Ida

AU - Liu, Yongmei

AU - Holliday, Elizabeth G.

AU - Schulz, Holger

AU - Heinrich, Joachim

AU - Davies, Gail

AU - Vonk, Judith M.

AU - Wojczynski, Mary

AU - Pouta, Anneli

AU - Johansson, Asa

AU - Wild, Sarah H.

AU - Ingelsson, Erik

AU - Rivadeneira, Fernando

AU - Voezke, Henry

AU - Hysi, Pirro G.

AU - Eiriksdottir, Gudny

AU - Morrison, Alanna C.

AU - Rotter, Jerome I.

AU - Gao, Wei

AU - Postma, Dirkje S.

AU - White, Wendy B.

AU - Rich, Stephen S.

AU - Hofman, Albert

AU - Aspelund, Thor

AU - Couper, David

AU - Smith, Lewis J.

AU - Psaty, Bruce M.

AU - Lohman, Kurt

AU - Burchard, Esteban G.

AU - Uitterlinden, Andre G.

AU - Garcia, Melissa

AU - Joubert, Bonnie R.

AU - McArdle, Wendy L.

AU - Musk, A. Bill

AU - Hansel, Nadia

AU - Heckbert, Susan R.

AU - Zgaga, Lina

AU - van Meurs, Joyce B. J.

AU - Navarro, Pau

AU - Rudan, Igor

AU - Oh, Yeon-Mok

AU - Redline, Susan

AU - Jarvis, Deborah L.

AU - Zhao, Jing Hua

AU - Rantanen, Taina

AU - O'Connor, George T.

AU - Ripatti, Samuli

AU - Scott, Rodney J.

AU - Karrasch, Stefan

AU - Grallert, Harald

AU - Gaddis, Nathan C.

AU - Starr, John M.

AU - Wijmenga, Cisca

AU - Minster, Ryan L.

AU - Lederer, David J.

AU - Pekkanen, Juha

AU - Gyllensten, Ulf

AU - Campbe, Harry

AU - Morris, Andrew P.

AU - Glaeser, Sven

AU - Hammond, Christopher J.

AU - Burkart, Kristin M.

AU - Beilby, John

AU - Kritchevsky, Stephen B.

AU - Gucinason, Vilrnundur

AU - Hancock, Dana B.

AU - Williams, Dale

AU - Polasek, Ozren

AU - Zemunik, Tatijana

AU - Kolcic, Ivana

AU - Petrini, Marcy F.

AU - Wjst, Matthias

AU - Kim, Woo Jin

AU - Porteous, David J.

AU - Scotland, Generation

AU - Smith, Blair H.

AU - Villanen, Anne

AU - Heliovaara, Markku

AU - Attia, John R.

AU - Sayers, Ian

AU - Hampel, Regina

AU - Gieger, Christian

AU - Deary, Ian J.

AU - Boezen, H. Marike

AU - Newman, Anne

AU - Jarvelin, Marjo-Riitta

AU - Wilson, James F.

AU - Lind, Lars

AU - Stricker, Bruno H.

AU - Teumer, Alexander

AU - Spector, Timothy D.

AU - Melen, Erik

AU - Peters, Marjolein J.

AU - Lange, Leslie A.

AU - Barr, R. Graham

AU - Bracke, Ken R.

AU - Verhamme, Fien M.

AU - Sung, Joohon

AU - Hiemstra, Pieter S.

AU - Cassano, Patricia A.

AU - Sood, Akshay

AU - Hayward, Caroline

AU - Dupuis, Josee

AU - Hall, Ian P.

AU - Brusselle, Guy G.

AU - Tobin, Martin D.

AU - London, Stephanie J.

PY - 2014/7

Y1 - 2014/7

KW - IDIOPATHIC PULMONARY-FIBROSIS

KW - LUNG-FUNCTION

KW - GENE-EXPRESSION

KW - HEALTHY TWIN

KW - HERITABILITY

KW - DISEASE

KW - TRAITS

KW - CELLS

KW - MORTALITY

KW - FAMILY

KW - 3111 Biomedicine

U2 - 10.1038/ng.3011

DO - 10.1038/ng.3011

M3 - Article

SN - 1061-4036

VL - 46

SP - 669

EP - 677

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -