Abstract
Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values
Original language | English |
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Journal | Blood Pressure |
Volume | 28 |
Issue number | 4 |
Pages (from-to) | 239-249 |
Number of pages | 11 |
ISSN | 0803-7051 |
DOIs | |
Publication status | Published - 2019 |
MoE publication type | A1 Journal article-refereed |
Fields of Science
- 3121 Internal medicine
- White-coat effect
- hypertension
- gene
- genome-wide
- SPG7
- RASGEF1B
- BLOOD-PRESSURE
- MASKED HYPERTENSION
- GENERAL-POPULATION
- GENETIC-VARIANTS
- HOME
- METAANALYSIS
- NEUROTICISM
- PREDICTORS