Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpelä; Teemu Niiranen; Antti Jula; Ilkka Pörsti; Antti J. Tikkakoski; Aki Havulinna; Terho Lehtimäki; Veikko Salomaa; Kimmo K. Kontula; Timo P. Hiltunen

doi:10.1080/08037051.2019.1604066

Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpelä, Teemu Niiranen, Antti Jula, Ilkka Pörsti, Antti J. Tikkakoski, Aki Havulinna, Terho Lehtimäki, Veikko Salomaa, Kimmo K. Kontula, Timo P. Hiltunen

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

Original language	English
Journal	Blood Pressure
Volume	28
Issue number	4
Pages (from-to)	239-249
Number of pages	11
ISSN	0803-7051
DOIs	https://doi.org/10.1080/08037051.2019.1604066
Publication status	Published - 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

3121 Internal medicine
White-coat effect
hypertension
gene
genome-wide
SPG7
RASGEF1B
BLOOD-PRESSURE
MASKED HYPERTENSION
GENERAL-POPULATION
GENETIC-VARIANTS
HOME
METAANALYSIS
NEUROTICISM
PREDICTORS

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10.1080/08037051.2019.1604066

Cite this

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title = "Genome-wide association study of white-coat effect in hypertensive patients",

abstract = "Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values",

keywords = "3121 Internal medicine, White-coat effect, hypertension, gene, genome-wide, SPG7, RASGEF1B, BLOOD-PRESSURE, MASKED HYPERTENSION, GENERAL-POPULATION, GENETIC-VARIANTS, HOME, METAANALYSIS, NEUROTICISM, PREDICTORS",

author = "Rimpel{\"a}, {Jenni M.} and Teemu Niiranen and Antti Jula and Ilkka P{\"o}rsti and Tikkakoski, {Antti J.} and Aki Havulinna and Terho Lehtim{\"a}ki and Veikko Salomaa and Kontula, {Kimmo K.} and Hiltunen, {Timo P.}",

year = "2019",

doi = "10.1080/08037051.2019.1604066",

language = "English",

volume = "28",

pages = "239--249",

journal = "Blood Pressure",

issn = "0803-7051",

publisher = "Taylor & Francis",

number = "4",

}

Genome-wide association study of white-coat effect in hypertensive patients. / Rimpelä, Jenni M.; Niiranen, Teemu; Jula, Antti; Pörsti, Ilkka; Tikkakoski, Antti J.; Havulinna, Aki; Lehtimäki, Terho; Salomaa, Veikko; Kontula, Kimmo K.; Hiltunen, Timo P.

In: Blood Pressure, Vol. 28, No. 4, 2019, p. 239-249.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Genome-wide association study of white-coat effect in hypertensive patients

AU - Rimpelä, Jenni M.

AU - Niiranen, Teemu

AU - Jula, Antti

AU - Pörsti, Ilkka

AU - Tikkakoski, Antti J.

AU - Havulinna, Aki

AU - Lehtimäki, Terho

AU - Salomaa, Veikko

AU - Kontula, Kimmo K.

AU - Hiltunen, Timo P.

PY - 2019

Y1 - 2019

N2 - Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

AB - Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

KW - 3121 Internal medicine

KW - White-coat effect

KW - hypertension

KW - gene

KW - genome-wide

KW - SPG7

KW - RASGEF1B

KW - BLOOD-PRESSURE

KW - MASKED HYPERTENSION

KW - GENERAL-POPULATION

KW - GENETIC-VARIANTS

KW - HOME

KW - METAANALYSIS

KW - NEUROTICISM

KW - PREDICTORS

U2 - 10.1080/08037051.2019.1604066

DO - 10.1080/08037051.2019.1604066

M3 - Article

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EP - 249

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

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