Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpelä, Teemu Niiranen, Antti Jula, Ilkka Pörsti, Antti J. Tikkakoski, Aki Havulinna, Terho Lehtimäki, Veikko Salomaa, Kimmo K. Kontula, Timo P. Hiltunen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

Original languageEnglish
JournalBlood Pressure
Volume28
Issue number4
Pages (from-to)239-249
Number of pages11
ISSN0803-7051
DOIs
Publication statusPublished - 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3121 Internal medicine
  • White-coat effect
  • hypertension
  • gene
  • genome-wide
  • SPG7
  • RASGEF1B
  • BLOOD-PRESSURE
  • MASKED HYPERTENSION
  • GENERAL-POPULATION
  • GENETIC-VARIANTS
  • HOME
  • METAANALYSIS
  • NEUROTICISM
  • PREDICTORS

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