Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Johannes Kettunen, Ayse Demirkan, Peter Wurtz, Harmen H. M. Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J. Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, Rene Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian BeekmanJoris Deelen, Ko Willems van Dijk, Tonu Esko, Jouke-Jan Hottenga, Elisabeth M. van Leeuwen, Terho Lehtimaki, Evelin Mihailov, Richard J Rose, Anton J. M. de Craen, Christian Gieger, Mika Kahonen, Markus Perola, Stefan Blankenberg, Markku J. Savolainen, Aswin Verhoeven, Jorma Viikari, Gonneke Willemsen, Dorret I. Boomsma, Cornelia M. van Duijn, Johan Eriksson, Antti Jula, Marjo-Riitta Jarvelin, Jaakko Kaprio, Andres Metspalu, Olli Raitakari, Veikko Salomaa, P. Eline Slagboom, Melanie Waldenberger, Samuli Ripatti, Mika Ala-Korpela

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number11122
JournalNature Communications
Volume7
Number of pages9
ISSN2041-1723
DOIs
Publication statusPublished - Mar 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • CORONARY-ARTERY-DISEASE
  • EVALUATING ROSUVASTATIN
  • GENETIC-DETERMINANTS
  • INTERVENTION TRIAL
  • JUPITER TRIAL
  • ASSOCIATION
  • LIPOPROTEIN(A)
  • THERAPY
  • RISK
  • JUSTIFICATION
  • 3121 Internal medicine

Cite this

Kettunen, J., Demirkan, A., Wurtz, P., Draisma, H. H. M., Haller, T., Rawal, R., ... Ala-Korpela, M. (2016). Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nature Communications, 7, [11122]. https://doi.org/10.1038/ncomms11122
Kettunen, Johannes ; Demirkan, Ayse ; Wurtz, Peter ; Draisma, Harmen H. M. ; Haller, Toomas ; Rawal, Rajesh ; Vaarhorst, Anika ; Kangas, Antti J. ; Lyytikäinen, Leo-Pekka ; Pirinen, Matti ; Pool, Rene ; Sarin, Antti-Pekka ; Soininen, Pasi ; Tukiainen, Taru ; Wang, Qin ; Tiainen, Mika ; Tynkkynen, Tuulia ; Amin, Najaf ; Zeller, Tanja ; Beekman, Marian ; Deelen, Joris ; van Dijk, Ko Willems ; Esko, Tonu ; Hottenga, Jouke-Jan ; van Leeuwen, Elisabeth M. ; Lehtimaki, Terho ; Mihailov, Evelin ; Rose, Richard J ; de Craen, Anton J. M. ; Gieger, Christian ; Kahonen, Mika ; Perola, Markus ; Blankenberg, Stefan ; Savolainen, Markku J. ; Verhoeven, Aswin ; Viikari, Jorma ; Willemsen, Gonneke ; Boomsma, Dorret I. ; van Duijn, Cornelia M. ; Eriksson, Johan ; Jula, Antti ; Jarvelin, Marjo-Riitta ; Kaprio, Jaakko ; Metspalu, Andres ; Raitakari, Olli ; Salomaa, Veikko ; Slagboom, P. Eline ; Waldenberger, Melanie ; Ripatti, Samuli ; Ala-Korpela, Mika. / Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. In: Nature Communications. 2016 ; Vol. 7.
@article{1a9b3ecf5d864050939d8595784b384c,
title = "Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA",
keywords = "CORONARY-ARTERY-DISEASE, EVALUATING ROSUVASTATIN, GENETIC-DETERMINANTS, INTERVENTION TRIAL, JUPITER TRIAL, ASSOCIATION, LIPOPROTEIN(A), THERAPY, RISK, JUSTIFICATION, 3121 Internal medicine",
author = "Johannes Kettunen and Ayse Demirkan and Peter Wurtz and Draisma, {Harmen H. M.} and Toomas Haller and Rajesh Rawal and Anika Vaarhorst and Kangas, {Antti J.} and Leo-Pekka Lyytik{\"a}inen and Matti Pirinen and Rene Pool and Antti-Pekka Sarin and Pasi Soininen and Taru Tukiainen and Qin Wang and Mika Tiainen and Tuulia Tynkkynen and Najaf Amin and Tanja Zeller and Marian Beekman and Joris Deelen and {van Dijk}, {Ko Willems} and Tonu Esko and Jouke-Jan Hottenga and {van Leeuwen}, {Elisabeth M.} and Terho Lehtimaki and Evelin Mihailov and Rose, {Richard J} and {de Craen}, {Anton J. M.} and Christian Gieger and Mika Kahonen and Markus Perola and Stefan Blankenberg and Savolainen, {Markku J.} and Aswin Verhoeven and Jorma Viikari and Gonneke Willemsen and Boomsma, {Dorret I.} and {van Duijn}, {Cornelia M.} and Johan Eriksson and Antti Jula and Marjo-Riitta Jarvelin and Jaakko Kaprio and Andres Metspalu and Olli Raitakari and Veikko Salomaa and Slagboom, {P. Eline} and Melanie Waldenberger and Samuli Ripatti and Mika Ala-Korpela",
year = "2016",
month = "3",
doi = "10.1038/ncomms11122",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

Kettunen, J, Demirkan, A, Wurtz, P, Draisma, HHM, Haller, T, Rawal, R, Vaarhorst, A, Kangas, AJ, Lyytikäinen, L-P, Pirinen, M, Pool, R, Sarin, A-P, Soininen, P, Tukiainen, T, Wang, Q, Tiainen, M, Tynkkynen, T, Amin, N, Zeller, T, Beekman, M, Deelen, J, van Dijk, KW, Esko, T, Hottenga, J-J, van Leeuwen, EM, Lehtimaki, T, Mihailov, E, Rose, RJ, de Craen, AJM, Gieger, C, Kahonen, M, Perola, M, Blankenberg, S, Savolainen, MJ, Verhoeven, A, Viikari, J, Willemsen, G, Boomsma, DI, van Duijn, CM, Eriksson, J, Jula, A, Jarvelin, M-R, Kaprio, J, Metspalu, A, Raitakari, O, Salomaa, V, Slagboom, PE, Waldenberger, M, Ripatti, S & Ala-Korpela, M 2016, 'Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA', Nature Communications, vol. 7, 11122. https://doi.org/10.1038/ncomms11122

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. / Kettunen, Johannes; Demirkan, Ayse; Wurtz, Peter; Draisma, Harmen H. M.; Haller, Toomas; Rawal, Rajesh; Vaarhorst, Anika; Kangas, Antti J.; Lyytikäinen, Leo-Pekka; Pirinen, Matti; Pool, Rene; Sarin, Antti-Pekka; Soininen, Pasi; Tukiainen, Taru; Wang, Qin; Tiainen, Mika; Tynkkynen, Tuulia; Amin, Najaf; Zeller, Tanja; Beekman, Marian; Deelen, Joris; van Dijk, Ko Willems; Esko, Tonu; Hottenga, Jouke-Jan; van Leeuwen, Elisabeth M.; Lehtimaki, Terho; Mihailov, Evelin; Rose, Richard J; de Craen, Anton J. M.; Gieger, Christian; Kahonen, Mika; Perola, Markus; Blankenberg, Stefan; Savolainen, Markku J.; Verhoeven, Aswin; Viikari, Jorma; Willemsen, Gonneke; Boomsma, Dorret I.; van Duijn, Cornelia M.; Eriksson, Johan; Jula, Antti; Jarvelin, Marjo-Riitta; Kaprio, Jaakko; Metspalu, Andres; Raitakari, Olli; Salomaa, Veikko; Slagboom, P. Eline; Waldenberger, Melanie; Ripatti, Samuli; Ala-Korpela, Mika.

In: Nature Communications, Vol. 7, 11122, 03.2016.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

AU - Kettunen, Johannes

AU - Demirkan, Ayse

AU - Wurtz, Peter

AU - Draisma, Harmen H. M.

AU - Haller, Toomas

AU - Rawal, Rajesh

AU - Vaarhorst, Anika

AU - Kangas, Antti J.

AU - Lyytikäinen, Leo-Pekka

AU - Pirinen, Matti

AU - Pool, Rene

AU - Sarin, Antti-Pekka

AU - Soininen, Pasi

AU - Tukiainen, Taru

AU - Wang, Qin

AU - Tiainen, Mika

AU - Tynkkynen, Tuulia

AU - Amin, Najaf

AU - Zeller, Tanja

AU - Beekman, Marian

AU - Deelen, Joris

AU - van Dijk, Ko Willems

AU - Esko, Tonu

AU - Hottenga, Jouke-Jan

AU - van Leeuwen, Elisabeth M.

AU - Lehtimaki, Terho

AU - Mihailov, Evelin

AU - Rose, Richard J

AU - de Craen, Anton J. M.

AU - Gieger, Christian

AU - Kahonen, Mika

AU - Perola, Markus

AU - Blankenberg, Stefan

AU - Savolainen, Markku J.

AU - Verhoeven, Aswin

AU - Viikari, Jorma

AU - Willemsen, Gonneke

AU - Boomsma, Dorret I.

AU - van Duijn, Cornelia M.

AU - Eriksson, Johan

AU - Jula, Antti

AU - Jarvelin, Marjo-Riitta

AU - Kaprio, Jaakko

AU - Metspalu, Andres

AU - Raitakari, Olli

AU - Salomaa, Veikko

AU - Slagboom, P. Eline

AU - Waldenberger, Melanie

AU - Ripatti, Samuli

AU - Ala-Korpela, Mika

PY - 2016/3

Y1 - 2016/3

KW - CORONARY-ARTERY-DISEASE

KW - EVALUATING ROSUVASTATIN

KW - GENETIC-DETERMINANTS

KW - INTERVENTION TRIAL

KW - JUPITER TRIAL

KW - ASSOCIATION

KW - LIPOPROTEIN(A)

KW - THERAPY

KW - RISK

KW - JUSTIFICATION

KW - 3121 Internal medicine

U2 - 10.1038/ncomms11122

DO - 10.1038/ncomms11122

M3 - Article

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 11122

ER -