Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

S Desrivières; A Lourdusamy; C Müller; F Ducci; CP Wong; M Kaakinen; A Pouta; AL Hartikainen; M Isohanni; P Charoen; Leena Palotie; N Freimer; P Elliott; MR Jarvelin; G Schumann

doi:10.1111/j.1369-1600.2010.00239.x

Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

S Desrivières, A Lourdusamy, C Müller , F Ducci, CP Wong, M Kaakinen, A Pouta, AL Hartikainen, M Isohanni, P Charoen, Leena Palotie, N Freimer, P Elliott, MR Jarvelin, G Schumann

Institute for Molecular Medicine Finland

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

ABSTRACT Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

Original language	English
Journal	Addiction Biology
Volume	16
Issue number	3
Pages (from-to)	510-513
Number of pages	4
ISSN	1355-6215
DOIs	https://doi.org/10.1111/j.1369-1600.2010.00239.x
Publication status	Published - 2011
MoE publication type	A1 Journal article-refereed

Fields of Science

3111 Biomedicine

Access to Document

10.1111/j.1369-1600.2010.00239.x

Cite this

Desrivières, S., Lourdusamy, A., Müller , C., Ducci, F., Wong, CP., Kaakinen, M., Pouta, A., Hartikainen, AL., Isohanni, M., Charoen, P., Palotie, L., Freimer, N., Elliott, P., Jarvelin, MR., & Schumann, G. (2011). Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents. Addiction Biology, 16(3), 510-513. https://doi.org/10.1111/j.1369-1600.2010.00239.x

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abstract = "ABSTRACT Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.",

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Desrivières, S, Lourdusamy, A, Müller , C, Ducci, F, Wong, CP, Kaakinen, M, Pouta, A, Hartikainen, AL, Isohanni, M, Charoen, P, Palotie, L, Freimer, N, Elliott, P, Jarvelin, MR & Schumann, G 2011, 'Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents', Addiction Biology, vol. 16, no. 3, pp. 510-513. https://doi.org/10.1111/j.1369-1600.2010.00239.x

TY - JOUR

T1 - Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

AU - Desrivières, S

AU - Lourdusamy, A

AU - Müller , C

AU - Ducci, F

AU - Wong, CP

AU - Kaakinen, M

AU - Pouta, A

AU - Hartikainen, AL

AU - Isohanni, M

AU - Charoen, P

AU - Palotie, Leena

AU - Freimer, N

AU - Elliott, P

AU - Jarvelin, MR

AU - Schumann, G

PY - 2011

Y1 - 2011

N2 - ABSTRACT Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

AB - ABSTRACT Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

KW - 3111 Biomedicine

U2 - 10.1111/j.1369-1600.2010.00239.x

DO - 10.1111/j.1369-1600.2010.00239.x

M3 - Article

SN - 1355-6215

VL - 16

SP - 510

EP - 513

JO - Addiction Biology

JF - Addiction Biology

IS - 3

ER -